Patents by Inventor Wanda O'Neal

Wanda O'Neal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Animal model for chronic obstructive pulmonary disease and cystic fibrosis
    Patent number: 8952214
    Abstract: A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel ? subunit, wherein said promoter construct directs expression of the epithelial sodium channel ? subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: February 10, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Richard C. Boucher, Jr., Wanda O'Neal, Barbara Grubb, Marcus Mall
  • ANIMAL MODEL FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND CYSTIC FIBROSIS
    Publication number: 20100263064
    Abstract: A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel ? subunit, wherein said promoter construct directs expression of the epithelial sodium channel ? subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
    Type: Application
    Filed: June 25, 2010
    Publication date: October 14, 2010
    Inventors: Richard C. Boucher, JR., Wanda O'Neal, Barbara Grubb, Marcus Mall
  • Animal model for chronic obstructive pulmonary disease and cystic fibrosis
    Patent number: 7772458
    Abstract: A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel ? subunit, wherein said promoter construct directs expression of the epithelial sodium channel ? subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: August 10, 2010
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Richard C. Boucher, Jr., Wanda O'Neal, Barbara Grubb, Marcus Mall
  • Animal model for chronic obstructive pulmonary disease and cystic fibrosis
    Patent number: 7514593
    Abstract: A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel ? subunit, wherein said promoter construct directs expression of the epithelial sodium channel ? subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: April 7, 2009
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Richard C. Boucher, Jr., Wanda O'Neal, Barbara Grubb, Marcus Mall
  • ANIMAL MODEL FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND CYSTIC FIBROSIS
    Publication number: 20090019555
    Abstract: A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel ? subunit, wherein said promoter construct directs expression of the epithelial sodium channel ? subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
    Type: Application
    Filed: September 19, 2008
    Publication date: January 15, 2009
    Applicant: The University of North Carolina
    Inventors: Richard C. Boucher, JR., Wanda O'Neal, Barbara Grubb, Marcus Mall
  • Animal model for chronic obstructive pulmonary disease and cystic fibrosis
    Publication number: 20040244067
    Abstract: A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel &bgr; subunit, wherein said promoter construct directs expression of the epithelial sodium channel &bgr; subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
    Type: Application
    Filed: May 30, 2003
    Publication date: December 2, 2004
    Inventors: Richard C. Boucher, Wanda O'Neal, Barbara Grubb, Marcus Mall