Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: Within many applications impulse radio based ultra-wideband (IR-UWB) transmission offers significant benefits for very short range high data rate communications when compared with existing standards and protocols. In many of these applications the main design goals are very low power consumption and very low complexity design for easy integration and cost reduction. Digitally programmable IR-UWB transmitters using an on-off keying modulation scheme on a 0.13 microns CMOS process operating on 1.2V supply and yielding power consumption as low as 0.9 mW at a 10 Mbps data rate with dynamic power control are enabled. The IR-UWB transmitters support new frequency hopping techniques providing more efficient spectrum usage and dynamic allocation of the spectrum when transmitting in highly congested frequency bands. Biphasic scrambling is also introduced for spectral line reduction.

Abstract: Within many applications impulse radio based ultra-wideband (IR-UWB) transmission offers significant benefits for very short range high data rate communications when compared with existing standards and protocols. In many of these applications the main design goals are very low power consumption and very low complexity design for easy integration and cost reduction. Digitally programmable IR-UWB transmitters using an on-off keying modulation scheme on a 0.13 microns CMOS process operating on 1.2V supply and yielding power consumption as low as 0.9 mW at a 10 Mbps data rate with dynamic power control are enabled. The IR-UWB transmitters support new frequency hopping techniques providing more efficient spectrum usage and dynamic allocation of the spectrum when transmitting in highly congested frequency bands. Biphasic scrambling is also introduced for spectral line reduction.

Abstract: Within many applications impulse radio based ultra-wideband (IR-UWB) transmission offers significant benefits for very short range high data rate communications when compared with existing standards and protocols. In many of these applications the main design goals are very low power consumption and very low complexity design for easy integration and cost reduction. Digitally programmable IR-UWB transmitters using an on-off keying modulation scheme on a 0.13 microns CMOS process operating on 1.2V supply and yielding power consumption as low as 0.9 mW at a 10 Mbps data rate with dynamic power control are enabled. The IR-UWB transmitters support new frequency hopping techniques providing more efficient spectrum usage and dynamic allocation of the spectrum when transmitting in highly congested frequency bands. Biphasic scrambling is also introduced for spectral line reduction.

Abstract: Within many applications impulse radio based ultra-wideband (IR-UWB) transmission offers significant benefits for very short range high data rate communications when compared with existing standards and protocols. In many of these applications the main design goals are very low power consumption and very low complexity design for easy integration and cost reduction. Digitally programmable IR-UWB transmitters using an on-off keying modulation scheme on a 0.13 microns CMOS process operating on 1.2V supply and yielding power consumption as low as 0.9 mW at a 10 Mbps data rate with dynamic power control are enabled. The IR-UWB transmitters support new frequency hopping techniques providing more efficient spectrum usage and dynamic allocation of the spectrum when transmitting in highly congested frequency bands. Biphasic scrambling is also introduced for spectral line reduction.

Abstract: Enhanced targeting systems and methods may be used to visualize trajectories for surgical instruments. Such a targeting system may have a fixture that can be secured at a predetermined location relative to a patient, a first light source attached to the fixture, and a second light source attached to the fixture. The first light source may project first light along a first plane, and the second light source may project second light along a second plane nonparallel to the first plane. At an intersection of the first and second planes, the first light and the second light may cooperate to produce a targeting line that indicates the desired trajectory. A controller may be connected to first and second sets of motors to orient the first and second light sources, respectively. The targeting line may be projected on a visualization aid that guides the surgical instrument along the trajectory.

Abstract: Enhanced targeting systems and methods may be used to visualize trajectories for surgical instruments. Such a targeting system may have a fixture that can be secured at a predetermined location relative to a patient, a first light source attached to the fixture, and a second light source attached to the fixture. The first light source may project first light along a first plane, and the second light source may project second light along a second plane nonparallel to the first plane. At an intersection of the first and second planes, the first light and the second light may cooperate to produce a targeting line that indicates the desired trajectory. A controller may be connected to first and second sets of motors to orient the first and second light sources, respectively. The targeting line may be projected on a visualization aid that guides the surgical instrument along the trajectory.

Abstract: A macromolecule includes a polymer directly tethered or bonded to a polyatomic functionality. The polyatomic functionality can be located at a terminus of the polymer and can be generated concurrent with or soon after formation of the polymer. The macro-molecule can be prepared from a functionalized polymer by hydrolyzing and condensing (e.g., by a sol-gel process) functionalities in which one or more alkoxy groups are bound to a silica atom in the presence of an excess of a compound that includes a Si, Ti, Zr, Sn, Al, or Fe atom. Such macromolecules can be used in the manufacture of vulcanizates and tire components, either alone or blended with other polymers and/or other particulate fillers.

Abstract: An approach is provided for performing collaborative graphical creation. It is determined that a plurality of modifications are made within a collaborative environment to an area of an image. The modifications are initiated by a plurality of members of a social network service. A conflict rule specified by the social network service is retrieved. One of the modifications is selected based on the conflict rule.

Abstract: A macromolecule includes a polymer directly tethered or bonded to a polyatomic functionality. The polyatomic functionality can be located at a terminus of the polymer and can be generated concurrent with or soon after formation of the polymer. The macro-molecule can be prepared from a functionalized polymer by hydrolyzing and condensing (e.g., by a sol-gel process) functionalities in which one or more alkoxy groups are bound to a silica atom in the presence of an excess of a compound that includes a Si, Ti, Zr, Sn, Al, or Fe atom. Such macromolecules can be used in the manufacture of vulcanizates and tire components, either alone or blended with other polymers and/or other particulate fillers.

Abstract: A method and apparatus provides for interpreting a foreign word or phrase using a contextual likelihood model and a dictionary. An apparatus may translate foreign language text by taking context into account and displaying the translation with alternatives on an adaptive user interface display. The contextual likelihood model may be interlaced with a dictionary. In an embodiment, the interaction between the contextual likelihood model and a dictionary may result in an adaptive adjustment of the meanings or the order of meanings displayed. The order of meanings displayed may be representative of the calculated likelihoods.