Abstract: The present disclosure relates to an in-silico analysis for inhibitors of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). The in-silico screening of Kobophenol A confirmed the effective binding at two positions, firstly at ACE2/Spike interface and secondly at the hydrophobic pocket by destabilizing the complex formation. Kobophenol A inhibited the cell death caused by viral infection without inducing cell toxicity in the absence of viral infection. The molecular dynamics of Kobophenol A indicated the stability of binding of Kobophenol A through hydrogen bond and stabilized at Y495 and K353 with an average distance of 2.95 ?. The binding affinity of Kobophenol A to the ACE2/Spike interface region and the ACE2 hydrophobic pocket is computed to be ?19.0±4.3 and ?24.9±6.9 kcal/mol respectively. Kobophenol A is useful as a potential drug for treatment of COVID-19.

Abstract: The present invention provides a handover method. An access node obtains mobility management entity pool MME pool information which is sent by a donor station of the access node and is used for identifying a mobility management entity MME to which a user equipment UE is attached. The access node initiates handover for the UE according to the MME pool information used for identifying the MME to which the UE is attached. The present invention further provides a communication device and a communication system.