Patents by Inventor Wang L Cheung

Wang L Cheung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphorylated histone h2b as apoptosis marker
    Publication number: 20040197838
    Abstract: The present invention is directed to the generation of antibodies against an &agr;-phosphorylated serine 14 residue on Histone 2B. This postranslational modification of the amino terminus of Histone 2B is associated with cells that are about to enter or are already undergoing apoptosis. These antibodies are useful in identifying apoptotic cells and serve as diagnostic and screening tools. The present invention is also directed to the Mst1 kinase and the isolation of compounds that modulate the activity of Mst1. This kinase has been identified as the enzyme responsible for creating this postranslational modification on Histone 2B in vivo.
    Type: Application
    Filed: January 30, 2004
    Publication date: October 7, 2004
    Inventors: C David Allis, Wang L Cheung, Ajiro Kozo