Abstract: A lipid delivery system, a virus-like structure (VLS) vaccine constructed therefrom, and a lipid particle capable of encapsulating an mRNA molecule encoding a SARS-CoV-2-specific antigen are provided. After the lipid particle encapsulates an mRNA molecule encoding a SARS-CoV-2 antigen, a SARS-CoV-2 S1 antigen protein can be embedded on a surface of an envelope structure of the lipid under specific buffer conditions to produce a VLS vaccine with an antigen-encoding mRNA molecule encapsulated inside and an outer membrane presenting a required viral antigen protein. The vaccine has a superior specific antibody-inducing ability to a SARS-CoV-2 mRNA vaccine and a polypeptide vaccine, can maintain a long-lasting high antibody level, and can also exhibit excellent immune binding abilities for the emerging different variants.

Abstract: Some aspects of this disclosure relate to strategies, systems, methods, compositions, and kits that are useful for production (e.g., evolution) of cytidine deaminase protein variants that are characterized by increased soluble expression and/or stability relative to the wild-type cytidine deaminase protein from which they are evolved. In some embodiments, evolved cytidine deaminase variants described by the disclosure are useful for incorporation into targeted nucleic acid editing proteins, for example in fusion proteins with a Cas9 domain or variant thereof.

Abstract: The present disclosure discloses a display device and a control method thereof. The display device includes a system on board and a timing controller. The timing controller is configured to: disconnect a communication connection with the system on board when communication with the system on board is not required, and periodically output a check signal; and stop outputting the check signal when communication with the system on board is required, and establish a communication connection with the system on board after a delay of a preset duration.

Abstract: The present disclosure discloses a can opener with an adaptation function, including a shell assembly; a circuit board and a speed reduction transmission assembly which are separately arranged in the shell assembly; an eccentric assembly movably penetrating through the shell assembly, wherein the eccentric assembly is in meshing and transmission connection with the speed reduction transmission assembly; an integrated knife flywheel penetrating through the shell assembly and detachably arranged on the eccentric assembly, wherein the integrated knife flywheel includes an integrally formed integrated knife flywheel main body, a resisting slot body, and a cutting tool body; the knife flywheel main body is in a slope design; the resisting slot body is an annular slot; the cutting tool body is a ring tool.

Abstract: The present disclosure relates to a supporting structure and a cleaning device. The supporting structure includes a top structure and a side structure. The top structure is connected and fixed to a main body of the cleaning device. The side structure includes: a dust bag installation structure, a dust bag being fittingly installed to the dust bag installation structure through an installation assembly on the dust bag; and a support air inlet channel for communicating a dirty air inlet of the cleaning device and a dust bag inlet.

Abstract: A cleaning apparatus, including: a suction system; a separation system; a filtration system; and a garbage collection system at least comprising a first garbage collection cavity configured to collect garbage passing through a primary separation system and a second garbage collection cavity configured to collect garbage passing through a secondary separation system, wherein the first garbage collection cavity and the second garbage collection cavity have a common airtight cover, a bottom of the second garbage collection cavity and a bottom of the first garbage collection cavity are located on the airtight cover in a direction extending outward from a center of the airtight cover, and the first garbage collection cavity and the second garbage collection cavity are isolated in a sealed manner in a direction perpendicular to a surface of the airtight cover.

Abstract: In an approach for smart test data workload generation, a processor receives a plurality of expected image frames for a user interface application to be tested. The plurality of expected image frames is pre-defined and represents a series of workflows and operations of the user interface application to be expected based on a design requirement. A processor calculates a first set of hash-values for each corresponding expected image frame. A processor samples the user interface application with a frequency to a plurality of testing image frames during a test run on the user interface application. A processor calculates a second set of hash-values for each sampled testing image frame. A processor compares the first set of hash-values to the second set of hash-values. A processor verifies that the second set of hash-values matches the first set of hash-values.

Abstract: adjustable keyboard bracket mechanism includes fixed seat provided with first axle for use as pivot and rotatable second axle; bracket set including first support with one end thereof fastened to the first axle and the second axle and the other end thereof provided with third axle, second support having one end thereof fastened to the second axle and the other end thereof provided with fourth axle and adjustment device set fastened to the third axle and the fourth axle, the adjustment device set including rotating adjustment block having two opposite sides thereof respectively provided with first friction wheels and two mating friction blocks each having inner side thereof provided with second friction wheel for fitting the first friction wheel to form the positioning or rotating adjustment status of the adjustment device set; and connecting seat assembled on the rotating adjustment block opposite to the third axle and the fourth axle.

Abstract: Provided is a novel PDGFR kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. Further provided are use and a method of the compound of formula (I) for preventing or treating conditions associated with PDGFR kinase activity, particularly use and a method for preventing or treating conditions associated with PDGFR? and/or PDGFR? kinase activity.

Abstract: The present invention provides a novel pan-RAF kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also provides a use or method of the compound of formula (I) in the treatment or prevention of a disorder related to the activity of RAF and/or RAS kinase.

Abstract: Described are techniques for predictive microservice activation. The techniques include training a machine learning model using a plurality of sequences of coordinates, where the plurality of sequences of coordinates are respectively based upon a corresponding plurality of series of vectors generated from historical usage data for an application and its associated microservices. The techniques further include inputting a new sequence of coordinates representing a series of application operations to the machine learning model. The techniques further include identifying a predicted microservice for future utilization based on an output vector generated by the machine learning model. The techniques further include activating the predicted microservice prior to the predicted microservice being called by the application.

Abstract: adjustable keyboard bracket mechanism includes fixed seat provided with first axle for use as pivot and rotatable second axle; bracket set including first support with one end thereof fastened to the first axle and the second axle and the other end thereof provided with third axle, second support having one end thereof fastened to the second axle and the other end thereof provided with fourth axle and adjustment device set fastened to the third axle and the fourth axle, the adjustment device set including rotating adjustment block having two opposite sides thereof respectively provided with first friction wheels and two mating friction blocks each having inner side thereof provided with second friction wheel for fitting the first friction wheel to form the positioning or rotating adjustment status of the adjustment device set; and connecting seat assembled on the rotating adjustment block opposite to the third axle and the fourth axle.

Abstract: A lifting device is disclosed. A base frame of the lifting device includes a first combination member, a sliding frame, a sliding groove on the sliding frame and having sliding holes, and shafts slidably disposed in the sliding holes. A conveyor is mounted on the two shafts and combined with the combination member, and the sliding frame is combined with the first lifting frame, and a sliding rod of the second lifting frame is disposed in the sliding groove, and a locating member is disposed on the sliding rod and combined with the conveyor. When the second lifting frame is vertically moved, the locating member can drive conveyor to move, and the conveyor can simultaneously drive the two shafts to slide in the sliding holes, and the second lifting frame can be slid on the sliding frame, to adjust the height of the second lifting frame individually.

Abstract: The present invention relates to a method for the production of n-butanol using a transgenic cell with heterologous expression of 2-hydroxyglutarate dehydrogenase, glutaconate-CoA transferase, (R)-2-hydroxyglutaryl-CoA dehydrogenase, glutaryl CoA dehydrogenase, trans-2-enoyl-CoA reductase (NAD+) and bifunctional aldehyde/alcohol dehydrogenase (NAD+).

Abstract: An electronic device mainboard includes a main body; an audio collecting component provided on the main body and configured to collect audio; a main controlling component provided on the main body, connected with the audio collecting component through a printed circuit printed on the main body and configured to receive and analyze the audio and then send out interaction instructions according to the audio; and an interaction component provided on the main body, connected with the main controlling component and configured to receive and execute the interaction instructions.

Abstract: A process planning apparatus based on augmented reality (AR) includes: a camera set capturing color and depth images of a processing machine and a probe operated by a human user in a real scene; a processor, which is signal-connected to the camera set and the processing machine, creates spatial intelligences for motion planning of the probe operated by the human user in an AR environment that combines a virtual workpiece with the real scene, and generates instructional data from the spatial intelligences to guide the human user to operate the probe to produce machine motion data for a manufacturing task; and an output interface, which is signal-connected to the processor and outputs scene data, the virtual workpiece and the instructional data to the human user.

Abstract: A non-limit multi-function viscoelastic support structure group, relating to a field of aerospace structural design, includes a basic structure, a supported structure and multiple viscoelastic support structure units. The multiple viscoelastic support structure units form a circular discontinuous group and are arranged between the basic structure and the supported structure. The viscoelastic support structure units are connected with the basic structure and the supported structure respectively in ways of pre-pressing and surface contact, and no fixed constrained relationship exists. The present invention absorbs a vibration energy through a viscoelastic effect of own structural material and forms a spring-oscillator vibration attenuation system with the supported structure.

Abstract: An experimental system for laser beam measurement and steering control, and relates to the technical field of optical, mechanical and electronic integration experimental systems. It includes: a high-precision optical mirror, a piezoelectric micro-actuator, a vibration exciter, a signal collection subsystem, a laser emitter, a beam splitter mirror, a fast steering mirror, a mechanical vibration isolation air bearing table, an optical vibration isolation air bearing table, a data processing and analyzing subsystem, and data transmission lines and power supply lines between subsystems and components. It uses a deflection angle of the laser beam as a control variation, can not only precisely measure the deflection angle of the laser beam, but also inhibit vibration of the high-precision optical mirror by using the piezoelectric micro-actuator and directly adjust the steering of the emitted laser beam by using the fast steering mirror, thereby improving precision of beam steering control.

Abstract: An electronic device mainboard includes a main body; an audio collecting component provided on the main body and configured to collect audio; a main controlling component provided on the main body, connected with the audio collecting component through a printed circuit printed on the main body and configured to receive and analyze the audio and then send out interaction instructions according to the audio; and an interaction component provided on the main body, connected with the main controlling component and configured to receive and execute the interaction instructions.

Abstract: A process planning apparatus based on augmented reality (AR) includes: a camera set capturing color and depth images of a processing machine and a probe operated by a human user in a real scene; a processor, which is signal-connected to the camera set and the processing machine, creates spatial intelligences for motion planning of the probe operated by the human user in an AR environment that combines a virtual workpiece with the real scene, and generates instructional data from the spatial intelligences to guide the human user to operate the probe to produce machine motion data for a manufacturing task; and an output interface, which is signal-connected to the processor and outputs scene data, the virtual workpiece and the instructional data to the human user.