Abstract: Provided is a fusion protein dimer using an antibody Fc region as the backbone, comprising a first and a second polypeptide chain. The first polypeptide chain comprises a first antibody Fc region and one or more single-domain antibodies fused to the first antibody Fc region. The second polypeptide chain comprises a second antibody Fc region and one or more single domain antibodies fused to the second antibody Fc region. The first polypeptide chain and/or the second polypeptide chain further comprise a cytokine fused to the Fc region of the respective antibody. Further provided is use of the fusion protein dimer in preparing an immunotherapeutic drug for treating tumors. The Fc fusion protein heterodimer not only increases the activity of a single domain antibody, but also significantly improves the biological activity of a cytokine.

Abstract: A method for manufacturing a semiconductor device and a semiconductor device produced thereby. For example and without limitation, various aspects of this disclosure provide methods for manufacturing a semiconductor device, and semiconductor devices produced thereby, that comprise forming an interposer including a reinforcement layer.

Abstract: A dynamic side blind zone method includes determining that a host vehicle is approaching a first lane that is nonparallel to a second lane. The host vehicle is moving in the second lane. The method further includes activating an adaptive side blind zone alert system of the host vehicle in response to determining that the host vehicle is approaching the first lane that is nonparallel to the second lane, determining a warning zone in response to activating the adaptive side blind zone alert system of the host vehicle, and detecting a remote vehicle inside the warning zone after determining the warning zone. The remote vehicle is moving in the first lane. The method further includes providing an alert to a vehicle user of the host vehicle in response to detecting that the remote vehicle is inside the warning zone.

Abstract: A strain sensor may have a conductive elastic yarn including a first fiber having a predetermined length and a shape of a fiber yarn and a second fiber having electrical conductivity and a sheet shape. The strain sensor may have a pair of wiring members electrically connected to both ends of the conductive elastic yarn. The conductive elastic yarn, with the second fiber wrapped around the first fiber, is twisted in a coil shape.

Abstract: An automobile vehicle continuous validation system includes a backend collecting data from a vehicle fleet and wirelessly communicating with the vehicle fleet. The backend is in wireless communication with at least one client. A vehicle module is provided on-board individual ones of multiple automobile vehicles of the vehicle fleet and performing an on-board vehicle validation analysis. A fleet-based validation module provided either at the backend or cloud based manages data defining a configuration of and a capability of the multiple automobile vehicles of the vehicle fleet. A validation manager generates validation tasks based on a user's definition or a desired production of the validation tasks of the validation analysis and a fleet vehicle availability. A client-side module remote from the multiple automobile vehicles of the vehicle fleet has interface items applied by the at least one client seeking to perform the validation analysis.

Abstract: The present invention discloses an operation instruction scheduling method and device for a NAND flash memory device. The method comprises: performing task decomposition on the operation instruction of the NAND flash memory device, and sending an obtained task to a corresponding task queue; sending a current task to a corresponding arbitration queue according to a task type of the current task in the task queue; and scheduling a NAND interface for a to-be-executed task in the arbitration queue according to priority information of the arbitration queue. Embodiments of the present invention can efficiently realize operation instruction scheduling of a NAND flash memory device, improve flexibility of operation instruction scheduling of the NAND flash memory device, and improve overall performance of the NAND flash memory device.

Abstract: Various formulations (to be used in the form of a single-segment or multi-segment transdermal patch) of bioactive compounds for pain management are described/disclosed. The multi-segmented transdermal patch can include one or more compatible bioactive compounds in each segment. Furthermore, formulations may include silk fibroin and/or microemulsion/nanoemulsion of bioactive compounds and/or microencapsulation/nanoencapsulation of bioactive compounds.

Abstract: The present invention discloses an operation instruction scheduling method and device for an NAND flash memory device. The method comprises: performing task decomposition on the operation instruction of the NAND flash memory device, and sending an obtained task to a corresponding task queue; sending a current task to a corresponding arbitration queue according to a task type of the current task in the task queue; and scheduling an NAND interface for a to-be-executed task in the arbitration queue according to priority information of the arbitration queue. Embodiments of the present invention can efficiently realize operation instruction scheduling of an NAND flash memory device, improve flexibility of operation instruction scheduling of the NAND flash memory device, and improve overall performance of the NAND flash memory device.

Abstract: Various formulations (to be used in the form of a single-segment or multi-segment transdermal patch) of bioactive compounds for pain management are described/disclosed. The multi-segmented transdermal patch can include one or more compatible bioactive compounds in each segment. Furthermore, formulations may include silk fibroin and/or microemulsion/nanoemulsion of bioactive compounds and/or microencapsulation/nanoencapsulation of bioactive compounds.

Abstract: A non-blocking N×M cross-connect optical switching device, system, and method having any number of inputs (N) and any number of outputs (M) is disclosed. In an embodiment of the invention, low power loss waveguides and low power loss electro-optical material switching elements are combined into a compact planar device. Depending on the direction of the electric field applied, the refractive index of a switching element is varied to alternate between a transmission state when the refractive indexes of the waveguides and electro-optical material are substantially equal and a reflective state when the refractive indexes are not equal. The transmission state allows input light to pass through a switching element to an output port. The reflective state does not allow light to pass through, thereby directing incident light to an alternative output port. Other embodiments comprising thermal optical materials as switching element are also described.

Abstract: Devices and methods for control of reflection and transmission of an optical wave by selective adjustment of the refractive index of a material through use of an applied electric field. In some devices, an electric field vector E is distributed in the material, where the material interfaces two optical waveguides. Since the refractive index n(E) of the material depends on the magnitude and direction of E, the electric field E can be varied to control n(E), relative to the refractive index of the interfaced waveguides, so as to make the material totally transmitting, totally reflecting, or partially reflecting of light that passes through one of the interfacing waveguides and is incident upon the material. Adjusting n(E) in such a material can also be used for selection of optical wavelengths by diffraction, wavelength selection of optical waves transmitted through mirror electrodes, and deflection of plane waves.