Abstract: The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.

Abstract: A method of improving a field operation that comprises a gas injection may include assessing a plurality of potential injection gases against a plurality of values of a plurality of parameters associated with a plurality of samples, where each of the plurality of potential injection gases comprises an acidic component, and where the plurality of parameters comprises fluid chemistry parameters and rock properties. The method may also include determining a proposed injection gas from among the plurality of potential injection gases for the field operation that comprises the gas injection to be performed using a first wellbore in fluidic communication with a first subterranean formation, a second wellbore in fluidic communication with the first subterranean formation, a third wellbore in fluidic communication with a second subterranean formation, or any combination thereof.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.

Abstract: Intelligent process management is provided. A start time is determined for an additional process to be run on a worker node within a duration of a sleep state of a task of a process already running on the worker node by adding a first defined buffer time to a determined start time of the sleep state of the task. A backfill time is determined for the additional process by subtracting a second defined buffer time from a determined end time of the sleep state of the task. A scheduling plan is generated for the additional process based on the start time and the backfill time corresponding to the additional process. The scheduling plan is executed to run the additional process on the worker node according to the start time and the backfill time corresponding to the additional process.

Abstract: At least one processor identifies dependency relationships among libraries in a repository of libraries. Using the dependency relationships among libraries, at least one machine learning model can be created that predicts with a confidence value a dependency between a given library and a target library. An L layer tree-like graph can be created, using the dependency relationships among libraries and an application package. L can be configurable. Versions of the libraries to use can be determined by running the at least one machine learning model for each pair of nodes having a dependency relationship in the L layer tree-like graph, the at least one machine learning model identifying the dependency relationship with a confidence value, where pairs of nodes having largest confidence values are selected as the versions of the libraries to use in the application package.

Abstract: The present invention relates to a channel fracturing method with alternative injection of conventional and capsule-type soluble proppants. The method includes the following steps: injecting pad fluid into a wellbore to break a formation and form fractures in the formation; alternately injecting a sand-carrying fluid containing conventional proppant and a sand-carrying fluid containing capsule-type soluble proppant into the wellbore in sequence to support fractures in the formation and continue to fracture the formation; injecting displacement fluid into the wellbore to completely displace the sand-carrying fluids in the wellbore into the fractures. The conventional proppant of less dosage is used. The capsule-type soluble proppant is less difficult to be developed and its solubility is sensitive to the fracture closure, which is conducive to the quick flowback after fracturing.

Abstract: The present invention relates to a channel fracturing method with alternative injection of conventional and capsule-type soluble proppants. The method includes the following steps: injecting pad fluid into a wellbore to break a formation and form fractures in the formation; alternately injecting a sand-carrying fluid containing conventional proppant and a sand-carrying fluid containing capsule-type soluble proppant into the wellbore in sequence to support fractures in the formation and continue to fracture the formation; injecting displacement fluid into the wellbore to completely displace the sand-carrying fluids in the wellbore into the fractures. The conventional proppant of less dosage is used. The capsule-type soluble proppant is less difficult to be developed and its solubility is sensitive to the fracture closure, which is conducive to the quick flowback after fracturing.

Abstract: A portable attitude determination apparatus and method are disclosed that can be used with a ship docking system. At least two receivers on a vessel receive Global Positioning System (GPS) satellite data. GPS carrier phase measurements are used to determine attitude (i.e., roll, pitch and yaw angles) of a moving platform. The phase measurements are processed to determine a precise vector from one receiver phase center to the other. The azimuth and elevation of a baseline vector is then computed. Float ambiguities between the two receivers are determined, and are used to provide initial estimates of antenna baseline length and attitude. A search procedure is then employed to find the actual integer ambiguities. Only GPS observables are needed; no other external data input is required.