Patents by Inventor Wanhe Li

Wanhe Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSPOSABLE ELEMENTS, TDP-43, AND NEURODEGENERATIVE DISORDERS
    Publication number: 20170121770
    Abstract: A method that includes measuring the expression level of at least one transposon in a biological sample from a subject; and determining whether the measured transposon expression exceeds a predetermined level, and if so, administering to the subject a transposon inhibitor in an amount effective to reduce the expression level of a transposon.
    Type: Application
    Filed: September 7, 2016
    Publication date: May 4, 2017
    Applicant: Cold Spring Harbor Laboratory
    Inventors: Joshua Dubnau, Wanhe Li, Lisa Prazak, Molly Hammell, Ying Jin
  • Transposon Activation During Aging and Neuronal Decline
    Publication number: 20170044531
    Abstract: The present invention relates to transposon activation and mobilization, particularly in the brain, during normal aging; reporter systems to detect such mobilization, along with cells and transgenic animals containing such systems; methods of monitoring neuronal function during normal aging; methods of determining the risk of age-related neuronal decline and age-related mortality; and the use of transposon inhibitors and apoptosis inhibitors to delay age-related neuronal decline and age-related mortality.
    Type: Application
    Filed: July 25, 2016
    Publication date: February 16, 2017
    Applicant: Cold Spring Harbor Laboratory
    Inventors: Joshua Dubnau, Wanhe Li, Lisa Prazak
  • Transposable elements, TDP-43, and neurodegenerative disorders
    Patent number: 9441223
    Abstract: A method that includes measuring the expression level of at least one transposon in a biological sample from a subject; and determining whether the measured transposon expression exceeds a predetermined level, and if so, administering to the subject a transposon inhibitor in an amount effective to reduce the expression level of a transposon.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: September 13, 2016
    Assignee: Cold Spring Harbor Laboratory, LLC
    Inventors: Josh Dubnau, Wanhe Li, Lisa Prazak, Molly Hammell, Ying Jin
  • Transposon activation during aging and neuronal decline
    Patent number: 9422605
    Abstract: The present invention relates to transposon activation and mobilization, particularly in the brain, during normal aging; reporter systems to detect such mobilization, along with cells and transgenic animals containing such systems; methods of monitoring neuronal function during normal aging; methods of determining the risk of age-related neuronal decline and age-related mortality; and the use of transposon inhibitors and apoptosis inhibitors to delay age-related neuronal decline and age-related mortality.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: August 23, 2016
    Assignee: Cold Spring Harbor Laboratory
    Inventors: Joshua Dubnau, Wanhe Li, Lisa Prazak
  • TRANSPOSON ACTIVATION DURING AGING AND NEURONAL DECLINE
    Publication number: 20140377758
    Abstract: The present invention relates to transposon activation and mobilization, particularly in the brain, during normal aging; reporter systems to detect such mobilization, along with cells and transgenic animals containing such systems; methods of monitoring neuronal function during normal aging; methods of determining the risk of age-related neuronal decline and age-related mortality; and the use of transposon inhibitors and apoptosis inhibitors to delay age-related neuronal decline and age-related mortality.
    Type: Application
    Filed: March 17, 2014
    Publication date: December 25, 2014
    Inventors: Joshua Dubnau, Wanhe Li, Lisa Prazak
  • TRANSPOSABLE ELEMENTS, TDP-43, AND NEURODEGENERATIVE DISORDERS
    Publication number: 20140113952
    Abstract: A method that includes measuring the expression level of at least one transposon in a biological sample from a subject; and determining whether the measured transposon expression exceeds a predetermined level, and if so, administering to the subject a transposon inhibitor in an amount effective to reduce the expression level of a transposon.
    Type: Application
    Filed: September 5, 2013
    Publication date: April 24, 2014
    Applicant: Cold Spring Harbor Laboratory
    Inventors: Josh Dubnau, Wanhe Li, Lisa Prazak, Molly Hammell, Ying Jin