Patents by Inventor Wanhui Liu
Wanhui Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230248732Abstract: Provided herein are simplified dosing regimens for administering paliperidone palmitate to a patient in need of treatment of schizophrenia or schizoaffective disorders.Type: ApplicationFiled: April 21, 2023Publication date: August 10, 2023Inventors: Youxin LI, Chunjie SHA, Fengjuan ZHAO, Changbing TU, Kaoxiang SUN, Wanhui LIU, Lifang SUN, Ying MENG
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Patent number: 11666573Abstract: Provided herein are simplified dosing regimens for administering paliperidone palmitate to a patient in need of treatment of schizophrenia or schizoaffective disorders.Type: GrantFiled: October 26, 2018Date of Patent: June 6, 2023Assignee: Geneora Pharma (Shijiazhuang) Co., Ltd.Inventors: Youxin Li, Chunjie Sha, Fengjuan Zhao, Changbing Tu, Kaoxiang Sun, Wanhui Liu, Lifang Sun, Ying Meng
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Patent number: 11110094Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.Type: GrantFiled: July 29, 2019Date of Patent: September 7, 2021Assignees: Shandong Luye Pharmaceutical Co., Ltd., Nanjing Luye Pharmaceutical Co., Ltd.Inventors: Kaoxiang Sun, Rongcai Liang, Oilin Wang, Wenyan Wang, Wanhui Liu, Youxin Li
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Publication number: 20200297729Abstract: Provided herein are simplified dosing regimens for administering paliperidone palmitate to a patient in need of treatment of schizophrenia or schizoaffective disorders.Type: ApplicationFiled: October 26, 2018Publication date: September 24, 2020Inventors: Youxin LI, Chunjie SHA, Fengjuan ZHAO, Changbing TU, Kaoxiang SUN, Wanhui LIU, Lifang SUN, Ying MENG
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Publication number: 20190379095Abstract: A dual-cycle ambient temperature control device for a battery pack of an electric vehicle comprises a semiconductor refrigerator and heater, an internal heat exchanger, an internal-circulation infusion pump, an external-circulation infusion pump, a compound heat exchanger, a heat exchange fan and an electronic control panel. The semiconductor refrigerator and heater, the internal-circulation infusion pump, the external-circulation infusion pump and the heat exchange fan are electrically connected to the electronic control panel.Type: ApplicationFiled: September 4, 2017Publication date: December 12, 2019Inventor: Wanhui LIU
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Publication number: 20190343840Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.Type: ApplicationFiled: July 29, 2019Publication date: November 14, 2019Inventors: Kaoxiang Sun, Rongcai Liang, Qilin Wang, Wenyan Wang, Wanhui Liu, Youxin Li
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Patent number: 10406161Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.Type: GrantFiled: September 27, 2018Date of Patent: September 10, 2019Assignees: SHANDONG LUYE PHARMACEUTICAL CO., LTD., NANJING LUYE PHARMACEUTICAL CO., LTD.Inventors: Kaoxiang Sun, Rongcai Liang, Qilin Wang, Wenyan Wang, Wanhui Liu, Youxin Li
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Patent number: 10258572Abstract: A composition of goserelin sustained release microspheres is provided. The microspheres comprise goserelin, at least one poly (lactide-co-glycolide) and poloxamer or PEG. The sustained release microspheres have comparatively high bioavailability, which promotes the drug taking its full effect and have entrapment efficiency over 90%.Type: GrantFiled: October 20, 2017Date of Patent: April 16, 2019Assignee: Shandong Luye Pharmaceutical Co., Ltd.Inventors: Wei Sun, Xuemei Zhang, Tao Wang, Guangyi Leng, Kaoxiang Sun, Youxin Li, Wanhui Liu
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Publication number: 20190022098Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.Type: ApplicationFiled: September 27, 2018Publication date: January 24, 2019Inventors: Kaoxiang Sun, Rongcai Liang, Qilin Wang, Wenyan Wang, Wanhui Liu, Youxin Li
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Patent number: 10098882Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation includes risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release micro sphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.Type: GrantFiled: November 9, 2016Date of Patent: October 16, 2018Assignees: Shandong Luye Pharmaceutical Co., Ltd., Nanjing Luye Pharmaceutical Co., Ltd.Inventors: Kaoxiang Sun, Rongcai Liang, Qilin Wang, Wenyan Wang, Wanhui Liu, Youxin Li
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Publication number: 20180036246Abstract: A composition of goserelin sustained release microspheres is provided. The microspheres comprise goserelin, at least one poly (lactide-co-glycolide) and poloxamer or PEG. The sustained release microspheres have comparatively high bioavailability, which promotes the drug taking its full effect and have entrapment efficiency over 90%.Type: ApplicationFiled: October 20, 2017Publication date: February 8, 2018Applicant: Shandong Luye Pharmaceutical Co., Ltd.Inventors: Wei Sun, Xuemei Zhang, Tao Wang, Guangyi Leng, Kaoxiang Sun, Youxin Li, Wanhui Liu
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Patent number: 9673126Abstract: A multi-functional semiconductor refrigerating and warming dual-purpose box includes a box body, a refrigerating and heating unit, a composite condenser unit, and a liquid delivering pump. The box body includes two independent rooms, a bottom machine room, an upper working room, and a lower working room. The refrigerating and heating unit includes an upper room semiconductor refrigerating and heating unit and a lower room semiconductor refrigerating and heating unit, the upper room semiconductor refrigerating and heating unit comprising an external heat exchanger of the upper room, a first semiconductor chilling plate, and an internal heat exchanger of the upper room. The composite condenser unit and the liquid delivering pump are connected to the external heat exchanger of the upper room and the external heat exchanger of the lower room through pipes. A manufacturing method of a multi-functional semiconductor refrigerating and warming dual-purpose box is also provided.Type: GrantFiled: November 4, 2013Date of Patent: June 6, 2017Assignee: Chongqing Semiconductor Klc Holdings Ltd.Inventor: Wanhui Liu
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Publication number: 20170056407Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation includes risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release micro sphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.Type: ApplicationFiled: November 9, 2016Publication date: March 2, 2017Inventors: Kaoxiang Sun, Rongcai Liang, Qilin Wang, Wenyan Wang, Wanhui Liu, Youxin Li
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Patent number: 9532991Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation includes risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release micro sphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.Type: GrantFiled: July 22, 2016Date of Patent: January 3, 2017Assignees: Shandong Luye Pharmaceutical Co., Ltd., Nanjing Luye Pharmaceutical Co., LtdInventors: Kaoxiang Sun, Rongcai Liang, Qilin Wang, Wenyan Wang, Wanhui Liu, Youxin Li
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Publication number: 20160331752Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation includes risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release micro sphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.Type: ApplicationFiled: July 22, 2016Publication date: November 17, 2016Inventors: Kaoxiang Sun, Rongcai Liang, Qilin Wang, Wenyan Wang, Wanhui Liu, Youxin Li
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Patent number: 9446135Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release micro sphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.Type: GrantFiled: April 10, 2012Date of Patent: September 20, 2016Assignee: Shandong Luye Pharmaceutical Co., Ltd.Inventors: Kaoxiang Sun, Rongcai Liang, Qilin Wang, Wenyan Wang, Wanhui Liu, Youxin Li
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Patent number: 9265835Abstract: The disclosure relates to a composition comprising rotigotine or a pharmaceutically acceptable salt thereof; at least one poly(lactide-co-glycolide) (PLGA); and at least one fatty acid, wherein the at least one fatty acid is at least 0.5% in weight relative to the total weight of the composition. The composition as disclosed herein has significantly reduced burse release effect. The disclosure also provides a method of treating Parkinson's disease comprising administering an effective amount of the composition as disclosed to a subject in need thereof.Type: GrantFiled: November 25, 2011Date of Patent: February 23, 2016Assignee: SHAN DONG LUYE PHARMACEUTICAL CO., LTD.Inventors: Youxin Li, Aiping Wang, Wanhui Liu, Kaoxiang Sun, Jun Li, Lifang Sun
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Publication number: 20160022584Abstract: A composition of goserelin sustained release microspheres is provided. The microspheres comprise goserelin, at least one poly(lactide-co-glycolide) and poloxamer or PEG. The sustained release microspheres have comparatively high bioavailability, which promotes the drug taking its full effect and have entrapment efficiency over 90%.Type: ApplicationFiled: October 8, 2015Publication date: January 28, 2016Applicant: Shandong Luye Pharmaceutical Co., Ltd.Inventors: Wei Sun, Xuemei Zhang, Tao Wang, Guangyi Leng, Kaoxiang Sun, Youxin Li, Wanhui Liu
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Patent number: 9199912Abstract: The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.Type: GrantFiled: April 23, 2014Date of Patent: December 1, 2015Assignees: SHANDONG LUYE PHARMACEUTICAL CO., LTD.Inventors: Youxin Li, Wanhui Liu, Yang Lv, Guanhua Du, Qingguo Meng, Mina Yang, Fengmei Zhou, Ju Li, Xuemei Zhang
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Publication number: 20150303124Abstract: A multi-functional semiconductor refrigerating and warming dual-purpose box includes a box body, a refrigerating and heating unit, a composite condenser unit, and a liquid delivering pump. The box body includes two independent rooms, a bottom machine room, an upper working room, and a lower working room. The refrigerating and heating unit includes an upper room semiconductor refrigerating and heating unit and a lower room semiconductor refrigerating and heating unit, the upper room semiconductor refrigerating and heating unit comprising an external heat exchanger of the upper room, a first semiconductor chilling plate, and an internal heat exchanger of the upper room. The composite condenser unit and the liquid delivering pump are connected to the external heat exchanger of the upper room and the external heat exchanger of the lower room through pipes. A manufacturing method of a multi-functional semiconductor refrigerating and warming dual-purpose box is also provided.Type: ApplicationFiled: November 4, 2013Publication date: October 22, 2015Applicant: CHONGQING SEMICONDUCTOR KLC HOLDINGS LTDInventors: Wanhui LIU, Maoxiang SHEN