Abstract: The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer, and intermediates for the synthesis of such compositions.

Abstract: The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.

Abstract: A projector having optical components, a power source unit, and a light source unit. The projector is capable of lowering its internal temperature utilizing: a first, second, and third fan (41, 42, 43) provided near the optical components for introducing external air from outside the projector to cool the optical components; and a fourth, fifth, and sixth exhaust fan (16, 17, 18). The fourth fan (16) blows the air that was taken in by the first, second, and third fan (41, 42, 43) and has cooled the optical components, onto the light source unit to further cool the light source unit. The fifth and sixth exhaust fans (17, 18) discharge the air that has cooled the light source unit and power supply unit out of the projector.

Abstract: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds.

Abstract: A duct was configured such that an incident side and an outgoing side of each of liquid crystal panels 34r, 34g, and 34b are formed with discharge ports r1 and r2, g1 and g2, and b1 and b2 to discharge the air from fans 41 to 43 through ducts 411 to 431, and at the same time, a PBS 28 for aligning the polarizing direction of the light from a light source lamp is formed with a discharge port p1 to discharge the air from the fan 43 through the duct 432, and an incident side discharge port b1 and an outgoing side discharge port b2 of the liquid crystal panel 34b corresponding to the blue light are formed with the ducts so as to discharge the air from the fans 43 and 41 which are different from each other. As a result, even when an amount of light per unit area of high luminance is increased, the liquid crystal panels and the polarizing plates and the PBS can be effectively cooled by three sets of the fans.

Abstract: A projector (1) has: a LAN card (800) having thereon an IC; liquid crystal panels (34) for modulating red, green, and blue light; optical components that includes polarization beam splitter (PBS) (23); and fans for cooling the optical components. The projector is provided with cooling ducts, which include a first air duct (411) having one end connected to the fan (41) and another end connected to an outlet for sending air to the liquid crystal panel for red light, a second air duct (421) having one end connected to the fan (42) and another end connected to an outlet for sending air to the liquid crystal panel for green light, and a third air duct (431) having one end connected to the fan (43) and another end connected to an outlet for sending air to the liquid crystal panel for blue light. The cooling ducts also include a branching air duct (412 or 422) that extends to the IC on the LAN card.

Abstract: A projector having optical components, a power source unit, and a light source unit. The projector is capable of lowering its internal temperature utilizing: a first, second, and third fan (41, 42, 43) provided near the optical components for introducing external air from outside the projector to cool the optical components; and a fourth, fifth, and sixth exhaust fan (16, 17, 18). The fourth fan (16) blows the air that was taken in by the first, second, and third fan (41, 42, 43) and has cooled the optical components, onto the light source unit to further cool the light source unit. The fifth and sixth exhaust fans (17, 18) discharge the air that has cooled the light source unit and power supply unit out of the projector.

Abstract: A duct was configured such that an incident side and an outgoing side of each of liquid crystal panels 34r, 34g, and 34b are formed with discharge ports r1 and r2, g1 and g2, and b1 and b2 to discharge the air from fans 41 to 43 through ducts 411 to 431, and at the same time, a PBS 28 for aligning the polarizing direction of the light from a light source lamp is formed with a discharge port p1 to discharge the air from the fan 43 through the duct 432, and an incident side discharge port b1 and an outgoing side discharge port b2 of the liquid crystal panel 34b corresponding to the blue light are formed with the ducts so as to discharge the air from the fans 43 and 41 which are different from each other. As a result, even when an amount of light per unit area of high luminance is increased, the liquid crystal panels and the polarizing plates and the PBS can be effectively cooled by three sets of the fans.

Abstract: In a projection type image display apparatus, a noise removal filter portion 15 is separated from a power source unit body 14. The separated noise removal filter portion 15 is provided in the vicinity of a side wall of a housing on which a power source inlet is provided, and of the power source unit body 14, respectively. Specifically, the power source unit body 14 is provided along a side wall of a front face of the horizontally-long housing of the projection type image display apparatus and the noise removal filter portion 15 is provided in a position opposed to the power source unit body 14 in a side wall of the back face. As a result, even when a light source lamp has a higher output, the projection type image display apparatus can achieve reduced noise by an improved cooling capability and reduced cost enabled by an efficient Electro Magnetic Compatibility (EMC) measure and the like.

Abstract: A first exhaust fan 17 for mainly discharging exhaust air from a light source lamp 19 to exterior and a second exhaust fan 18 for mainly discharging exhaust air from parts other than the light source lamp 19 are arranged to be parallel to each other. An end of the exhaust fan 17 facing the other exhaust fan 18 is moved to the inner side and the one exhaust fan 17 is inclined to discharge air in an exhaust direction toward a direction along which air is discharged from the other exhaust fan 18. There is provided a cooling fan 16 that blows air to an interior air blow outlet 161 communicating with the interior of the light source lamp 19 and exterior air blow outlets 162 and 163 communicating with an outer surface to cool the light source lamp 19. The exterior air blow outlets 162 and 163 are deviated from the center of the outer surface of the light source lamp 19. The cooling fan 16 is used to allow the exhaust air used for cooling the light source lamp 19 to be discharged through the first exhaust fan 17.

Abstract: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases.

Abstract: This invention provide a projector apparatus enabled to lower its exhaust air temperature by adding only minor modifications to the existing structure, without altering its basic structure. The liquid crystal projector apparatus of the invention has a casing (1) for accommodating therein a light source (4), an optical system adapted to construct imaging light in response to a beam of light received from the light source, a power supply (9), and a cooling unit (6) mounted on the side wall of the casing (1) to cool the components in the casing. Provided on the inner wall of the casing is an air inspiration mechanism (16, 17, 18, 126) in association with the exhaust unit (6), whereby the exhaust unit (6) can inspire ambient air through the air inspiration mechanism to lower the temperature of the air to be expired from the exhaust unit.

Abstract: The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally

Abstract: The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.

Abstract: Novel intermediates of the formula They are used in the preparation of macrocyclic analogs.

Abstract: Intermediate compounds of the formulas for use in the preparation of macrocyclic analogs.

Abstract: The invention provides halichondrin analogs having pharmaceutical activity, such as anticancer or antimitotic (mitosis-blocking) activity, and methods of identifying agents that induce a sustained mitotic block in a cell after transient exposure of the cell to the agents.