Patents by Inventor Wanming SHI

Wanming SHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KETOREDUCTASE MUTANT AND APPLICATIONS THEREOF
    Publication number: 20230257720
    Abstract: Provided is a ketoreductase mutant and applications thereof. Compared with an amino acid sequence shown in SEQ ID NO: 1, the amino acid sequence of the ketoreductase mutant includes at least one of the following mutation sites: L198P, S96W/I/L/V, M194L or L1526, herein “/” means “or.” The ketoreductase mutant provides high selectivity and high activity with respect to a substrate ketone, and the application of the mutant in a catalytic reduction reaction of a ketone substrate may increase the production efficiency of a chiral alcohol compound corresponding thereto.
    Type: Application
    Filed: July 8, 2020
    Publication date: August 17, 2023
    Inventors: Hao HONG, Gage JAMES, Yi XIAO, Na ZHANG, Fang LIU, Zujian WANG, Wanming SHI, Junjie YAN, Mujiao ZHANG
  • TRANSAMINASE MUTANT AND USE THEREOF
    Publication number: 20220380817
    Abstract: An amino acid sequence of the transaminase mutant is an amino acid sequence obtained by a mutation of an amino acid sequence is shown in SEQ ID NO: 1. The mutation occurred at least one of the following mutation sites: G17V, L36P, Q40H, G69Y, H70T, L73A, V77G, V77S, V77T, A78I, Y130M, Y130V, Y130T, N132I, N132T, K141S, K142S, K142T, R143P, G144F, G144W, G144Y, E145D, E145S, E145G, K146R, L148A, L148I and the like.
    Type: Application
    Filed: October 25, 2019
    Publication date: December 1, 2022
    Inventors: Hao HONG, Gage JAMES, Yi XIAO, Fang LIU, Na ZHANG, Zujian WANG, Junjie YAN, Wanming SHI, Mujiao ZHANG, Ye LIU