Patents by Inventor Wanqiu Chen

Wanqiu Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systemic and local ex vivo gene therapy of the skeleton
    Patent number: 9789162
    Abstract: Methods are disclosed herein for increasing bone mass and strength or bone fracture healing in a subject. The methods include administering to the subject a therapeutically effective amount of multipotent stem cells, wherein each multipotent stem cell is transformed with a recombinant nucleic acid molecule comprising a heterologous promoter operably linked to a nucleic acid encoding platelet derived growth factor (PDGF) B, and wherein the multipotent stem cells express a sufficient amount of PDGFB to increase bone mass and strength or bone fracture healing. A lentiviral vector also is disclosed that includes a phosphoglycerate kinase-1 (PGK) promoter operably linked to a nucleic acid encoding PDGFB.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: October 17, 2017
    Assignees: The United States of America as represented by the Department of Veteran Affairs, Loma Linda University
    Inventors: David Baylink, Kin-Hing William Lau, Wanqiu Chen, Xiao-Bing Zhang
  • SYSTEMIC AND LOCAL EX VIVO GENE THERAPY OF THE SKELETON
    Publication number: 20160120944
    Abstract: Methods are disclosed herein for increasing bone mass and strength or bone fracture healing in a subject. The methods include administering to the subject a therapeutically effective amount of multipotent stem cells, wherein each multipotent stem cell is transformed with a recombinant nucleic acid molecule comprising a heterologous promoter operably linked to a nucleic acid encoding platelet derived growth factor (PDGF) B, and wherein the multipotent stem cells express a sufficient amount of PDGFB to increase bone mass and strength or bone fracture healing. A lentiviral vector also is disclosed that includes a phosphoglycerate kinase-1 (PGK) promoter operably linked to a nucleic acid encoding PDGFB.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 5, 2016
    Applicants: The United States Government as represented by the Department of Veterans Affairs, Loma Linda University
    Inventors: David Baylink, Kin-Hing William Lau, Wanqiu Chen, Xiao-Bing Zhang