Abstract: Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in clinical trials with mavacamten and with mavacamten and other myosin inhibitors in the pre-clinical setting, new insights into how myosin inhibitors can be used beneficially to impact the disease state of HCM and other diseases are provided herein.

Abstract: The present invention relates to a method for increasing the stability of cooling fluid for the engine. This invention selects the most preferred conditions, e.g. the composition of the solution, pH value, means and amount of addition, and proportion of silicate added, so that the products thereof have excellent properties for inhibiting corrosion for many kinds of metals, being with low costs and good storage stability. Moreover, since this method is simple, it is easy to be put into practice and utilized.

Abstract: The present invention relates to a method for increasing the stability of the cooling fluid for engine. This invention selects the most preferred conditions, e.g. the composition of the solution, pH value, means and amount of addition, and proportion of silicate added, so that the products thereof has excellent property for inhibiting corrosion for many kinds of metals, being with low costs and good storage stability. Moreover, since this method is simple, it is easy to be put into practice and popularization.