Abstract: The invention belongs to the technical field of biomedical testing, and particularly relates to a biomarker for diagnosis, treatment, and prognosis for hepatocellular carcinoma bone metastasis (HCC) and application thereof. The application of biomarker VAPA for preparing a reagent or a kit for diagnosis, treatment, and prognosis for HCC bone metastasis. The application of the reagent that detects VAPA expression levels in blood and tissues for preparing a reagent or kit for diagnosis, treatment, and prognosis for HCC bone metastasis. Compared with the diagnostic kits in the prior art that can only detect bone metastasis after it has occurred, the VAPA described in this invention offers a more specific and sensitive assay kit for the early prediction, diagnosis, disease progression assessment, treatment efficacy evaluation, drug guidance, and prognosis assessment of HCC bone metastasis. Additionally, the VAPA may also serve as a target for therapeutic interventions in bone metastasis.

Abstract: Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in clinical trials with mavacamten and with mavacamten and other myosin inhibitors in the pre-clinical setting, new insights into how myosin inhibitors can be used beneficially to impact the disease state of HCM and other diseases are provided herein.

Abstract: The present invention relates to a method for increasing the stability of cooling fluid for the engine. This invention selects the most preferred conditions, e.g. the composition of the solution, pH value, means and amount of addition, and proportion of silicate added, so that the products thereof have excellent properties for inhibiting corrosion for many kinds of metals, being with low costs and good storage stability. Moreover, since this method is simple, it is easy to be put into practice and utilized.

Abstract: The present invention relates to a method for increasing the stability of the cooling fluid for engine. This invention selects the most preferred conditions, e.g. the composition of the solution, pH value, means and amount of addition, and proportion of silicate added, so that the products thereof has excellent property for inhibiting corrosion for many kinds of metals, being with low costs and good storage stability. Moreover, since this method is simple, it is easy to be put into practice and popularization.