Abstract: A microneedle device comprising: a substrate comprising one or more layers; and at least one microneedle which extends from the substrate; wherein the substrate comprises at least one layer which is a high surface energy material layer and which is capable of retaining the at least one microneedle.

Abstract: A transdermal delivery device comprising a roller, at least one microneedle supported by the roller, and at least one reservoir for a liquid pharmaceutical composition; wherein movement of the roller over the skin of a patient will cause it to rotate and bring the at least one microneedle into contact with the skin of the patient and to bring the at least one microneedle into fluid communication with the at least one reservoir. A method of assembling a transdermal delivery device comprising attaching the at least one microneedle to the device and attaching the at least one reservoir to the device. A method of administering a liquid pharmaceutical composition to a patient using a transdermal delivery device.

Abstract: In a method and device the TCP load offered in the uplink is manipulated such that an offered load asymmetry is achieved. Using such an arrangement it is possible to compensate for a link asymmetry when uplink and downlink connections are sharing the same uplink buffer in order to increase performance of the downlink. The method and device are capable of increasing the download performance both in the case when TCP connections are terminated in a different device than the terminal where the link layer is terminated, as well as when the TCP connections are terminated in the same device as the link-layer.

Abstract: In a method and device the TCP load offered in the uplink is manipulated such that an offered load asymmetry is achieved. Using such an arrangement it is possible to compensate for a link asymmetry when uplink and downlink connections are sharing the same uplink buffer in order to increase performance of the downlink. The method and device are capable of increasing the download performance both in the case when TCP connections are terminated in a different device than the terminal where the link layer is terminated, as well as when the TCP connections are terminated in the same device as the link-layer.