Patents by Inventor Ward Celus

Ward Celus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD8+ T-cells lacking plexins and their application in cancer treatment
    Patent number: 12472254
    Abstract: The invention relates to field of cancer therapy. In particular, it relates to (populations of) isolated CD8+ T-cells substantially lacking functional plexin-A2 and/or plexin-A4. Such cells can be employed in e.g. adoptive cell transfer to treat a tumor or cancer.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: November 18, 2025
    Assignees: VIB VZW, Katholieke Universiteit Leuven, K.U. Leuven R&D
    Inventors: Massimiliano Mazzone, Ana Oliveira, Ward Celus
  • CD8+ T-CELLS LACKING PLEXINS AND THEIR APPLICATION IN CANCER TREATMENT
    Publication number: 20220228116
    Abstract: The invention relates to field of cancer therapy. In particular, it relates to (populations of) isolated CD8+ T-cells substantially lacking functional plexin-A2 and/or plexin-A4. Such cells can be employed in e.g. adoptive cell transfer to treat a tumor or cancer.
    Type: Application
    Filed: May 28, 2020
    Publication date: July 21, 2022
    Inventors: Massimiliano Mazzone, Ana Oliveira, Ward Celus
  • Cancer Treatment by Targeting Plexins in the Immune Compartment
    Publication number: 20220220197
    Abstract: The invention relates to compounds inhibiting plexin-A2 and/or plexin-A4, with said compounds specifically targeting plexin-A2 and/or plexin-A4 on or in CD8-positive (CD8+) T-cells. Medical uses of such compounds are also part of the invention.
    Type: Application
    Filed: May 28, 2020
    Publication date: July 14, 2022
    Inventors: Massimiliano Mazzone, Ana Oliveira, Ward Celus, Rosa Martín-Pérez, Catelijne Stortelers