Patents by Inventor Warren Chew

Warren Chew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the Synthesis of Derivatives of 2,3-Dihydro-1,4-Dioxino-[2,3-f] Quinolines
    Publication number: 20070123705
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Application
    Filed: December 4, 2006
    Publication date: May 31, 2007
    Applicant: Wyeth
    Inventors: Anita Chan, Timothy Curran, Silvio Iera, Warren Chew, John Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
    Patent number: 7202256
    Abstract: Methods for the synthesis of CCI-779 and proline-CCI-779 are described, including a method involving lipase-catalyzed acetylation of 42-hydroxy of rapamycin with a vinyl ester of 2,2-bis(hydroxymethyl) propionic acid in an organic solvent followed by deprotection. Also provided are products containing proline-CCI-779 and uses thereof.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: April 10, 2007
    Assignee: Wyeth
    Inventors: Jianxin Gu, Mark E. Ruppen, Panolil Raveendranath, Warren Chew, Chia-Cheng Shaw
  • Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline
    Patent number: 7166723
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: January 23, 2007
    Assignee: Wyeth
    Inventors: Anita Wai-Yin Chan, Timothy T. Curran, Silvio Iera, Warren Chew, John Hamilton Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Regioselective synthesis of CCI-779
    Patent number: 7153957
    Abstract: A method for regioselective synthesis of CCl-779 based on boronate chemistry is provided. Also provided are novel intermediates useful in this method.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: December 26, 2006
    Assignee: Wyeth
    Inventors: Warren Chew, Chia-Cheng Shaw
  • Method of preparing 3-cyano-quinolines and intermediates made thereby
    Publication number: 20060270669
    Abstract: The present invention relates to methods for preparing substituted 3-cyanoquinolines and intermediates obtained by the methods of the present invention. The methods of the invention comprise reacting an N-aryl-2-propanimide with phosphoryl chloride to produce the substituted 3-cyanoquinolines. The methods further comprise reacting arylamines, orthoformates and active methylenes to produce the N-aryl-2-propenamide.
    Type: Application
    Filed: May 25, 2006
    Publication date: November 30, 2006
    Inventors: Warren Chew, Maria Papamichelakis
  • Methods of synthesizing substituted 3-cyanoquinolines and intermediates thereof
    Publication number: 20060270668
    Abstract: The invention is directed to methods of making substituted 3-cyanoquinolines, including compounds according to the following formula: The methods are amenable to large scale manufacture, avoid the use of chromatographic separations, and provide stable, high purity product more efficiently than in the prior art.
    Type: Application
    Filed: May 25, 2006
    Publication date: November 30, 2006
    Applicant: WYETH
    Inventors: Warren Chew, Gloria Cheal, Jacqueline Lunetta
  • Methods of synthesizing 6-alkylaminoquinoline derivatives
    Publication number: 20060270670
    Abstract: The present invention is directed to a method of synthizing compounds of formula (I): wherein X, Z, V, R1, R3, R4, G2, n, x, y, and z are defined herein. This invention also includes a method of preparing acid compounds of formula (VII): wherein R is H, and R4, x, y, and z are as defined herein and PG is a protecting group. This invention is also directed to (E)N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(methylamino)-2-butenamide, compositions containing it and methods of using the to treat cancer.
    Type: Application
    Filed: May 25, 2006
    Publication date: November 30, 2006
    Inventors: Warren Chew, Youchu Wang, Sridhar Rabindran, Carolyn Discafani-Marro, John McGinnis II, Allan Wissner
  • Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
    Patent number: 7126025
    Abstract: This invention provides a compound of Formula (I): wherein S1 and S2 are each independently, hydrogen, alkyl, alkenyl, alkynyl, aralkyl, substituted or unsubstituted aryl, and S1 and S2 together with the nitrogen to which they are attached form a nitrogen containing heteroaryl and a pharmaceutically acceptable salt thereof; a method of preparing the compound of Formula (I), and use of the compound of Formula (I) in the preparation of 3-cyano quinolines.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: October 24, 2006
    Assignee: Wyeth
    Inventors: John Leo Considine, Sylvain Daigneault, Warren Chew, Silvio Iera, Scott Mason Duncan, Jianxin Ren
  • Purification of rapamycin
    Publication number: 20060199954
    Abstract: Purified rapamycin and a chemical process for obtaining the purified rapamycin are described.
    Type: Application
    Filed: February 22, 2006
    Publication date: September 7, 2006
    Applicant: Wyeth
    Inventors: Chia-Cheng Shaw, Warren Chew, Bogdan Wilk
  • Recovery of CCI-779 from mother liquors
    Publication number: 20060199253
    Abstract: The invention provides a process for recovering CCI-779 from mother liquors.
    Type: Application
    Filed: February 22, 2006
    Publication date: September 7, 2006
    Applicant: Wyeth
    Inventors: Chia-Cheng Shaw, Warren Chew, Bogdan Wilk, Genevieve Fortier
  • Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline
    Patent number: 7038052
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: May 2, 2006
    Assignee: Wyeth
    Inventors: Anita W. Chan, Timothy T. Curran, Silvio Iera, Warren Chew, John H. Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline
    Publication number: 20060074240
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Application
    Filed: November 18, 2005
    Publication date: April 6, 2006
    Applicant: Wyeth
    Inventors: Anita Chan, Timothy Curran, Silvio Iera, Warren Chew, John Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Process for the scalable synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]-indole derivatives
    Publication number: 20060058532
    Abstract: The invention is directed to a process of synthesizing compounds of formula (VI): wherein R1-R9, R3?, R4? and Y are as set forth in the specification, and said method is useful for large scale synthesis thereof. The invention is also directed to useful intermediates for synthesizing the compounds of formula (VI) and processes of preparing said intermediates.
    Type: Application
    Filed: September 9, 2005
    Publication date: March 16, 2006
    Inventors: Warren Chew, Gloria Cheal, Jacqueline Lunetta, Christopher Demerson
  • Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
    Publication number: 20050234086
    Abstract: Methods for the synthesis of CCI-779 and proline-CCI-779 are described, including a method involving lipase-catalyzed acetylation of 42-hydroxy of rapamycin with a vinyl ester of 2,2-bis(hydroxymethyl) propionic acid in an organic solvent followed by deprotection. Also provided are products containing proline-CCI-779 and uses thereof.
    Type: Application
    Filed: April 12, 2005
    Publication date: October 20, 2005
    Applicant: Wyeth
    Inventors: Jianxin Gu, Mark Ruppen, Panolil Raveendranath, Warren Chew, Chia-Cheng Shaw
  • Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof
    Publication number: 20050159446
    Abstract: This invention is directed to methods of preparing 4-substituted quinoline compounds as intermediates in the manufacture of receptor tyrosine kinase inhibitors and intermediate compounds used in the methods thereof, wherein the 4-substituted quinoline compound has the following general formula (I): wherein substitutions at LG?, PG, A, G, R1 and R4 are set forth in the specification.
    Type: Application
    Filed: January 14, 2005
    Publication date: July 21, 2005
    Inventors: Warren Chew, Maria Papamichelakis, Youchu Wang
  • Regioselective synthesis of CCI-779
    Publication number: 20050033046
    Abstract: A method for regioselective synthesis of CCl-779 based on boronate chemistry is provided. Also provided are novel intermediates useful in this method.
    Type: Application
    Filed: July 30, 2004
    Publication date: February 10, 2005
    Inventors: Warren Chew, Chia-Cheng Shaw
  • Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline
    Publication number: 20040186123
    Abstract: Methods of preparing compounds of Formula I 1
    Type: Application
    Filed: December 12, 2003
    Publication date: September 23, 2004
    Applicant: Wyeth
    Inventors: Anita W. Chan, Timothy T. Curran, Silvio Iera, Warren Chew, John H. Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
    Publication number: 20040162442
    Abstract: This invention provides a compound of Formula (I): 1
    Type: Application
    Filed: January 15, 2004
    Publication date: August 19, 2004
    Applicant: Wyeth
    Inventors: John Leo Considine, Sylvain Daigneault, Warren Chew, Silvio Iera, Scott Mason Duncan, Jianxin Ren
  • Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino- [2,3-f] quinoline
    Patent number: 6693197
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Grant
    Filed: May 14, 2002
    Date of Patent: February 17, 2004
    Assignee: Wyeth
    Inventors: Anita W. Chan, Timothy T. Curran, Silvio Iera, Warren Chew, John H. Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline
    Publication number: 20020187983
    Abstract: Methods of preparing compounds of Formula I 1
    Type: Application
    Filed: May 14, 2002
    Publication date: December 12, 2002
    Applicant: Wyeth
    Inventors: Anita W. Chan, Timothy T. Curran, Silvio Iera, Warren Chew, John H. Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding