Patents by Inventor Warren Colvin

Warren Colvin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolation of natural L-?-3-indolylalanine and enrichment of natural aliphatic amino acid mixtures with natural L-?-3-indolylalanine
    Patent number: 7030248
    Abstract: Processes for extracting amino acids from mixtures of amino acids, and compositions and mixtures formed therefrom. Applications include isolating natural L-?-3-indolylalanine (L-?-3) and providing natural or other amino acid mixtures enriched with the extracted L-?-3. The source of amino acids may include a natural source, such as enzymatic or other natural protein hydrolysates containing mixtures of free amino acids. The process includes contacting the mixture of amino acids with a resin or hydrophobic substance that is attractive to aromatic amino acids but not attractive to aliphatic amino acids to separate the aromatic amino acids from the rest of the mixture. This contacting may include agitating the mixture and hydrophobic substance to increase contact therebetween. The L-?-3 may then be separated from the monocylic amino acids by contacting the hydrophobic substance with an acid, and L-?-3 may be removed from the hydrophobic substance by contact with a base.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: April 18, 2006
    Assignee: AminoPath Labs, LLC
    Inventors: Robert L. Pollack, John C. Godfrey, F. Warren Colvin
  • Isolation of natural L-beta-3-indolylalanine and enrichment of natural aliphatic amino acid mixtures with natural L-beta-3-indolylalanine
    Publication number: 20040030154
    Abstract: Processes for extracting amino acids from mixtures of amino acids, and compositions and mixtures formed therefrom. Applications include isolating natural L-&bgr;-3-indolylalanine (L-&bgr;-3) and providing natural or other amino acid mixtures enriched with the extracted L-&bgr;-3. The source of amino acids may include a natural source, such as enzymatic or other natural protein hydrolysates containing mixtures of free amino acids. The process includes contacting the mixture of amino acids with a resin or hydrophobic substance that is attractive to aromatic amino acids but not attractive to aliphatic amino acids to separate the aromatic amino acids from the rest of the mixture. This contacting may include agitating the mixture and hydrophobic substance to increase contact therebetween. The L-&bgr;-3 may then be separated from the monocylic amino acids by contacting the hydrophobic substance with an acid, and L-&bgr;-3 may be removed from the hydrophobic substance by contact with a base.
    Type: Application
    Filed: February 14, 2003
    Publication date: February 12, 2004
    Inventors: Robert L. Pollack, John C. Godfrey, F. Warren Colvin
  • Aminooxy-containing linker compounds for formation of stably-linked conjugates and methods related thereto
    Patent number: 5880270
    Abstract: Linker compounds for formation of stably-linked conjugates are disclosed. Such linker compounds are aminooxy-containing linker compounds useful in forming conjugates having stable oxime linkages. The stably-linked conjugates have utility in a variety of immunodiagnostic and separation techniques.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: March 9, 1999
    Assignees: CellPro, Incorporated, Emerald Diagnostics, Inc.
    Inventors: Ronald W. Berninger, Mark S. Lodge, Stanley Joseph Tarnowski, Jr., Floyd Warren Colvin, John Michael Brinkley
  • Fluorescent protein binding assays with unsymmetrical fluorescein derivatives
    Patent number: 4652531
    Abstract: Unsymmetrically substituted 6-hydroxy-3H-xanthen-3-ones for use as fluorescers or quenchers, particularly conjugated to provide reagents in competitive protein binding assays. Substituents are aliphatic groups bonded to an annular carbon atom through carbon or oxygen.
    Type: Grant
    Filed: March 7, 1984
    Date of Patent: March 24, 1987
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Pyare Khanna, Warren Colvin
  • Unsymmetrical fluorescein derivatives
    Patent number: 4439356
    Abstract: Unsymmetrically substituted 6-hydroxy-3H-xanthen-3-ones for use as fluorescers or quenchers, particularly conjugated to provide reagents in competitive protein binding assays. Substituents are aliphatic groups bonded to an annular carbon atom through carbon or oxygen.
    Type: Grant
    Filed: March 3, 1981
    Date of Patent: March 27, 1984
    Assignee: Syva Company
    Inventors: Pyare Khanna, Warren Colvin