Patents by Inventor Warren K. Hoeffler

Warren K. Hoeffler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPONGY EPITHELIAL CELL SCAFFOLD FOR VASCULARIZING WOUNDS
    Publication number: 20080279830
    Abstract: The present invention provides isolated apoptotic epithelial scaffolds. The scaffolds find use in promoting re-vascularization of wounded tissues. The present invention also provides isolated or ex vivo tri-layered cell sorted tissues comprised of a bottom layer comprised of an apoptotic epithelial scaffold, a middle layer comprised of mesenchymal cells, and a top layer comprised of non-differentiated epithelial cells. The invention further provides in vitro methods for generating isolated or ex vivo tri-layered cell sorted tissues by exposing cultured mixtures of epithelial and mesenchymal cells to an inflammatory cytokine. Further provided are methods of promoting wound healing and re-vascularization of wounds by contacting wounded tissue with the apoptotic epithelial scaffolds of the invention.
    Type: Application
    Filed: May 8, 2008
    Publication date: November 13, 2008
    Applicant: Xgene Corporation
    Inventor: WARREN K. HOEFFLER
  • In vitro synthesis of a layered cell sorted tissue
    Patent number: 6815202
    Abstract: The present invention relates to a layered cell sorted tissue that is formed in vitro. The tissue is generated by the spontaneous sorting of cells from a homogenous cell mixture into discrete layers by cell type. Connective tissue components, such as fibronectin, may be used to manipulate orientation of the layers during the cell sorting process. The layered cell sorted tissue may be used as a skin graft for burns, wounds, and ulcers. The tissue may also be used in assays to determine effects of chemicals or drugs on human tissue in vitro as well as provide an in vitro assay for tumor cell metastasis.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: November 9, 2004
    Assignee: Xgene Corporation
    Inventors: Warren K. Hoeffler, Deborah Finlay
  • In vitro synthesis of a layered cell sorted tissue
    Publication number: 20020120950
    Abstract: The present invention relates to a layered cell sorted tissue that is formed in vitro. The tissue is generated by the spontaneous sorting of cells from a homogenous cell mixture into discrete layers by cell type. Connective tissue components, such as fibronectin, may be used to manipulate orientation of the layers during the cell sorting process. The layered cell sorted tissue may be used as a skin graft for bums, wounds, and ulcers. The tissue may also be used in assays to determine effects of chemicals or drugs on human tissue in vitro as well as provide an in vitro assay for tumor cell metastasis.
    Type: Application
    Filed: December 7, 2001
    Publication date: August 29, 2002
    Inventors: Warren K. Hoeffler, Deborah Finlay