Abstract: Described herein are techniques to enable a mobile device to perform multi-source estimation of an altitude for a location. A baseline altitude may be determined at ground level for a location and used to calibrate a barometric pressure sensor on the mobile device. The calibrated barometric pressure sensor can then estimate changes in altitude relative to ground level based on detected pressure differentials, allowing a relative altitude to ground to be determined. Baseline calibration for the barometric sensor calibration can be performed to determine an ambient ground-level barometric pressure.

Abstract: The invention discloses a method for preparation of spray dried solid dispersions (SDD) comprising an active pharmaceutical ingredient (API) and a dispersion polymer (DISPPOL), wherein the spray drying is done with a supersaturated solution of API in a solvent mixture comprising two solvents, this supersaturated solution further comprising DISPPOL.

Abstract: A method for preparing an amorphous solid dispersion by spray drying a spray solution comprising a) a mixed solvent, the mixed solvent comprising i. a solvent 1 selected from the group consisting of methyl acetate, methyl formate, ethyl acetate, ethyl formate and mixtures thereof; ii.

Abstract: Described herein are techniques to enable a mobile device to perform multi-source estimation of an altitude for a location. A baseline altitude may be determined at ground level for a location and used to calibrate a barometric pressure sensor on the mobile device. The calibrated barometric pressure sensor can then estimate changes in altitude relative to ground level based on detected pressure differentials, allowing a relative altitude to ground to be determined. Baseline calibration for the barometric sensor calibration can be performed to determine an ambient ground-level barometric pressure.

Abstract: The invention discloses a method for preparation of spray dried solid dispersions, SDD, comprising an active agent, AA, such as an active pharmaceutical ingredient, API, and a dispersion polymer, DISPPOL, wherein the spray drying is done with a solution of AA and of DISPPOL in a solvent comprising C1-3 alkanol and formic acid, and optionally water.

Abstract: The invention discloses a method for preparation of spray dried solid dispersions, SDD, comprising an active agent, AA, such as an active pharmaceutical ingredient, API, and a dispersion polymer, DISPPOL, wherein the spray drying is done with a solution of AA and of DISPPOL in a solvent comprising C1-3 alkanol and acetic acid, and optionally water.

Abstract: The invention discloses a method for preparation of spray dried solid dispersions (SDD) comprising an active pharmaceutical ingredient (API) and a dispersion polymer (DISPPOL), wherein the spray drying is done with a supersaturated solution of API in a solvent mixture comprising two solvents, one is acetic acid, this supersaturated solution further comprising DISPPOL.

Abstract: A computer-implemented method for applying passive strain indicators to a component includes creating a plurality of surface curves and a plurality of data points on each of the plurality of surface curves, the plurality of surface curves and the plurality of data points defining the exterior surface of the component. The method further includes receiving data indicative of a user input selection of a selected surface curve of the plurality of surface curves, a selected data point of the plurality of data points on the selected surface curve, and a selected rotation angle. The method further includes determining an output dimension, location, and orientation of a passive strain indicator. The method further includes providing one or more control signals to a passive strain indicator application system to cause the system to apply the passive strain indicator having the output dimension, location, and orientation to the component.

Abstract: A multi-warhead munition includes a first cylindrical warhead having a cavity filled with high explosive, and a second cylindrical warhead offset axially from the first cylindrical warhead. The second cylindrical warhead is a transformable, segmented warhead including a plurality of segments each having an outer segment face bounding a cavity of the segment filled with high explosive. The segments are elongated and mounted at one end for rotation away from an axis of the munition to an open position in which the segment faces are pointed in a forward direction for detonation. Rotation may generally be somewhere in a broad range from about 105 degrees to about 170 degrees, obtaining different effects in different sub-ranges. The munition includes first and second detonators for the first and second cylindrical warheads respectively, the second detonator simultaneously detonating the segments of the second cylindrical warhead.

Abstract: A computer-implemented method for applying passive strain indicators to a component includes obtaining an output dimension, location, and orientation of each of a plurality of passive strain indicators for the component. The method further includes determining an inverse rotation matrix for each of the plurality of passive strain indicators based on the orientation and location of each of the plurality of passive strain indicators. The method further includes determining a movement profile for each of the plurality of passive strain indicators based on the inverse rotation matrix. The method further includes providing one or more control signals to a passive strain indicator application system to cause the system to apply each of the plurality of passive strain indicators to the component based on the movement profile for each of the plurality of passive strain indicators.

Abstract: A computer-implemented method for applying passive strain indicators to a component includes creating a plurality of surface curves and a plurality of data points on each of the plurality of surface curves, the plurality of surface curves and the plurality of data points defining the exterior surface of the component. The method further includes receiving data indicative of a user input selection of a selected surface curve of the plurality of surface curves, a selected data point of the plurality of data points on the selected surface curve, and a selected rotation angle. The method further includes determining an output dimension, location, and orientation of a passive strain indicator. The method further includes providing one or more control signals to a passive strain indicator application system to cause the system to apply the passive strain indicator having the output dimension, location, and orientation to the component.

Abstract: A monitoring system for a gas turbine includes a processor configured to receive an operating signal indicating an operating parameter of the gas turbine. The processor is configured to predict an occurrence of a lean blowout (LBO) event based on the operating parameter and an entropy ratio of combustion dynamics associated with a combustor of the gas turbine, wherein the LBO event corresponds to when the combustor stops firing. The processor is configured to send an alarm signal indicating the predicted LBO event to an electronic device prior to the occurrence of the LBO event.

Abstract: A monitoring system for a gas turbine includes a processor configured to receive an operating signal indicating an operating parameter of the gas turbine. The processor is configured to predict an occurrence of a lean blowout (LBO) event based on the operating parameter and an entropy ratio of combustion dynamics associated with a combustor of the gas turbine, wherein the LBO event corresponds to when the combustor stops firing. The processor is configured to send an alarm signal indicating the predicted LBO event to an electronic device prior to the occurrence of the LBO event.

Abstract: A multi-warhead munition includes a first cylindrical warhead having a cavity filled with high explosive, and a second cylindrical warhead offset axially from the first cylindrical warhead. The second cylindrical warhead is a transformable, segmented warhead including a plurality of segments each having an outer segment face bounding a cavity of the segment filled with high explosive. The segments are elongated and mounted at one end for rotation away from an axis of the munition to an open position in which the segment faces are pointed in a forward direction for detonation. Rotation may generally be somewhere in a broad range from about 105 degrees to about 170 degrees, obtaining different effects in different sub-ranges. The munition includes first and second detonators for the first and second cylindrical warheads respectively, the second detonator simultaneously detonating the segments of the second cylindrical warhead.

Abstract: Systems and methods for gas turbine combustion profile monitoring are disclosed. In one embodiment, a method for detecting an anomaly in a combustion section of a gas turbine is disclosed. The method includes receiving, from a plurality of thermal sensors disposed around an exhaust section of a gas turbine, exhaust profile data of the gas turbine. The method further analyzes the exhaust profile data to calculate statistical features associated with a peak-trough pattern. The method further determines, using a machine learning algorithm, that the statistical features are abnormal. In response to the determination, the method processes the exhaust profile data for a predetermined period of time and reports an anomaly in a combustion section of the gas turbine if the statistical features remain abnormal for the predetermined period of time.

Abstract: A method of monitoring for combustion anomalies in a gas turbomachine includes sensing an exhaust gas temperature at each of a plurality of temperature sensors arranged in an exhaust system of the gas turbomachine, comparing the exhaust gas temperature at each of the plurality of temperature sensors with a mean exhaust gas temperature, determining whether the exhaust gas temperature at one or more of the plurality of temperature sensors deviates from the mean exhaust temperature by a predetermined threshold value, and identifying an instantaneous combustion anomaly at one or more of the temperature sensors sensing a temperature deviating from the mean exhaust temperature by more than the predetermined threshold value.

Abstract: Systems and methods for gas turbine combustion profile monitoring are disclosed. In one embodiment, a method for detecting an anomaly in a combustion section of a gas turbine is disclosed. The method includes receiving, from a plurality of thermal sensors disposed around an exhaust section of a gas turbine, exhaust profile data of the gas turbine. The method further analyzes the exhaust profile data to calculate statistical features associated with a peak-trough pattern. The method further determines, using a machine learning algorithm, that the statistical features are abnormal. In response to the determination, the method processes the exhaust profile data for a predetermined period of time and reports an anomaly in a combustion section of the gas turbine if the statistical features remain abnormal for the predetermined period of time.

Abstract: A method of monitoring for combustion anomalies in a gas turbomachine includes sensing an exhaust gas temperature at each of a plurality of temperature sensors arranged in an exhaust system of the gas turbomachine, comparing the exhaust gas temperature at each of the plurality of temperature sensors with a mean exhaust gas temperature, determining whether the exhaust gas temperature at one or more of the plurality of temperature sensors deviates from the mean exhaust temperature by a predetermined threshold value, and identifying an instantaneous combustion anomaly at one or more of the temperature sensors sensing a temperature deviating from the mean exhaust temperature by more than the predetermined threshold value.

Abstract: The invention relates to compounds of formula (I) wherein R1, R2, R1a, R1b have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.