Publication number: 20240092781
Abstract: Aryl piperidine compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions: wherein X, R2a, R2b, R3, R4, R5a and R5b are as defined herein.
Type:
Application
Filed:
September 21, 2023
Publication date:
March 21, 2024
Inventors:
Michael K. Ameriks, Cynthia B. Berry, Krisztián Biró, Pablo Garcia-Reynaga, Andrew V. Samant, Warren S. Wade