Patents by Inventor Warren Strober

Warren Strober has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mucosal cytotoxic T lymphocyte responses
    Patent number: 6749856
    Abstract: The invention provides methods for induction of an antigen-specific, mucosal cytotoxic T lymphocyte response useful in preventing and treating infections with pathogens that gain entry via a mucosal surface.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: June 15, 2004
    Assignee: The United States of America, as represented by the Department of Health and Human Services
    Inventors: Jay A. Berzofsky, Igor M. Belyakov, Michael A. Derby, Brian L. Kelsall, Warren Strober
  • Methods for enhancing oral tolerance and treating autoimmune disease using inhibitors of interleukin-12
    Publication number: 20030228311
    Abstract: The present invention provides a method for enhancing oral tolerance to an antigen associated with an autoimmune disease in a subject having the autoimmune disease comprising orally administering to the subject an antigen associated with the autoimmune disease and administering an inhibitor of interleukin-12 in amounts sufficient to enhance oral tolerance. Also provided in the present invention is a method for treating or preventing an autoimmune disease in a subject comprising orally administering to the subject an antigen associated with the autoimmune disease and administering an inhibitor of interleukin-12 in amounts sufficient to treat or prevent the auto immune disease, thereby treating or preventing the autoimmune disease.
    Type: Application
    Filed: April 21, 2003
    Publication date: December 11, 2003
    Inventors: Warren Strober, Brian Kelsall, Thomas Marth
  • Methods of treating colitis using STAT-4 anti-sense oligonucleotides
    Patent number: 6479465
    Abstract: The present invention provides a method of treating or preventing the inflammatory response of an inflammatory bowel disease in a subject, comprising administering to the subject an amount of a STAT-4 antisense oligonucleotide effective in treating or preventing the inflammatory response of the inflammatory bowel disease.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: November 12, 2002
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Warren Strober, Ivan Fuss, Markus Neurath, Atsushi Kitani
  • Methods of treating colitis using STAT-4 anti-sense oligonucleotides
    Publication number: 20020077308
    Abstract: The present invention provides a method of treating or preventing the inflammatory response of an inflammatory bowel disease in a subject, comprising administering to the subject an amount of a STAT-4 antisense oligonucleotide effective in treating or preventing the inflammatory response of the inflammatory bowel disease.
    Type: Application
    Filed: March 19, 2001
    Publication date: June 20, 2002
    Applicant: The Government of The United States of America, Department of Health and Human Services
    Inventors: Warren Strober, Ivan Fuss, Markus Neurath, Atsushi Kitani
  • Methods for enhancing oral tolerance and treating autoimmune disease using inhibitors of interleukin-12
    Publication number: 20010051159
    Abstract: The present invention provides a method for enhancing oral tolerance to an antigen associated with an autoimmune disease in a subject having the autoimmune disease comprising orally administering to the subject an antigen associated with the autoimmune disease and administering an inhibitor of interleukin-12 in amounts sufficient to enhance oral tolerance. Also provided in the present invention is a method for treating or preventing an autoimmune disease in a subject comprising orally administering to the subject an antigen associated with the autoimmune disease and administering an inhibitor of interleukin-12 in amounts sufficient to treat or prevent the autoimmune disease, thereby treating or preventing the autoimmune disease.
    Type: Application
    Filed: December 7, 2000
    Publication date: December 13, 2001
    Applicant: Government of the United States of America, Department of Health and Human Services
    Inventors: Warren Strober, Brian Kelsall, Thomas Marth
  • Methods of treating established colitis using antibodies against IL-12
    Patent number: 5853697
    Abstract: The present invention provides a method for treating the inflammatory response of an established colitis in a subject with inflammatory bowel disease (IBD), comprising administering to a subject diagnosed with an established colitis from an IBD an amount of an antibody to interleukin-12 effective in reducing the colitis-inducing effect of interleukin-12. Also provided is a method for screening a substance for its effectiveness in reducing the inflammatory response of an established colitis comprising obtaining an animal having an established colitis; administering the substance to an animal; and assaying the animal for an effect on interleukin-12 which results in the reduction of the inflammatory response of the colitis, an amount of reduction of the inflammatory response greater than the amount of reduction produced by the administration of antibodies against interferon-gamma or tumor necrosis factor-alpha indicating an effective substance.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: December 29, 1998
    Assignee: The United States of America, as represented by the Department of Health & Human Services
    Inventors: Warren Strober, Ivan Fuss, Markus Neurath