Patents by Inventor Warren Wakarchuk

Warren Wakarchuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8771991
    Abstract: The invention relates to sialate-O-acetyltransferase (SOAT) polypeptides, nucleic acids that encode the polypeptides, and methods of using the polypeptides.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: July 8, 2014
    Assignee: National Research Council of Canada
    Inventors: Michel Gilbert, Warren Wakarchuk, Scott Houliston
  • Patent number: 8748135
    Abstract: ?-1,4-galactosyltransferase (CgtD) polypeptides, nucleic acids that encode the polypeptides, including a polypeptide from Campylobacter jejuni strain LIO87 have been isolated and characterized. A method of producing a galactosylated saccharide comprising contacting an acceptor saccharide containing a terminal galactose, a donor substrate comprising a galactose moiety and one of the CgtD polypeptides is described.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: June 10, 2014
    Assignee: National Research Council of Canada
    Inventors: Michel Gilbert, Warren Wakarchuk, Scott Houliston
  • Patent number: 8460909
    Abstract: The invention relates to poly-sialyltransferse polypeptides with enhanced solubility and activity and methods of using the poly-sialyltransferases for production of poly-sialylated end products, e.g., oligosaccharides, glycoproteins and glycolipids.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: June 11, 2013
    Assignee: National Research Council of Canada
    Inventors: Warren Wakarchuk, Elizabeth Willis, Michel Gilbert
  • Patent number: 8409583
    Abstract: CgtB proteins with enhanced beta 1,3-galactosaminyltransferase activity, nucleic acids that encode the CgtB proteins and methods for use of the CgtB proteins.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: April 2, 2013
    Assignee: National Research Council of Canada
    Inventors: Stephane Bernatchez, Michel Gilbert, Warren Wakarchuk
  • Patent number: 8278069
    Abstract: The invention relates to ?-1,3-N-acetylgalactosaminyltransferase polypeptides, nucleic acids that encode the polypeptides, and methods of using the polypeptides.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: October 2, 2012
    Assignee: National Research Council of Canada
    Inventors: Michel Gilbert, Warren Wakarchuk, Scott Houliston
  • Patent number: 8257949
    Abstract: The invention relates to a fusion protein comprising a bifunctional sialytransferase and a poly-sialytransferase and methods to use the fusion proteins for production of poly-sialylated end products, e.g. oligosaccharides and glycoproteins.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: September 4, 2012
    Assignee: National Research Council of Canada
    Inventors: Warren Wakarchuk, Michel Gilbert
  • Publication number: 20110111454
    Abstract: CgtB proteins with enhanced beta 1,3-galactosaminyltransferase activity, nucleic acids that encode the CgtB proteins and methods for use of the CgtB proteins.
    Type: Application
    Filed: April 18, 2008
    Publication date: May 12, 2011
    Applicant: National Research Council of Canada
    Inventors: Stephane Bernatchez, Michel Gilbert, Warren Wakarchuk
  • Publication number: 20100216185
    Abstract: The invention relates to poly-sialyltransferse polypeptides with enhanced solubility and activity and methods of using the poly-sialyltransferases for production of poly-sialylated end products, e.g., oligosaccharides, glycoproteins and glycolipids.
    Type: Application
    Filed: June 13, 2008
    Publication date: August 26, 2010
    Inventors: Warren Wakarchuk, Elizabeth Willis, Michel Gilbert
  • Publication number: 20100167349
    Abstract: The invention relates to sialate-O-acetyltransferase (SOAT) polypeptides, nucleic acids that encode the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: August 11, 2006
    Publication date: July 1, 2010
    Applicant: National Research Council of Canada
    Inventors: Michael Gilbert, Warren Wakarchuk, Scott Houliston
  • Publication number: 20090286288
    Abstract: ?-1,4-galactosyltransferase (CgtD) polypeptides, nucleic acids that encode the polypeptides, including a polypeptide from Campylobacter jejuni strain LIO87 have been isolated and characterized A method of producing a galactosylated saccharide comprising contacting an acceptor saccharide containing a terminal galactose, a donor substrate comprising a galactose moiety and one of the CgtD polypeptides is described.
    Type: Application
    Filed: May 1, 2007
    Publication date: November 19, 2009
    Applicant: National Research Council of Canada
    Inventors: Michel Gilbert, Warren Wakarchuk, Scott Houliston
  • Publication number: 20090246832
    Abstract: The invention relates to a fusion protein comprising a bifunctional sialytransferase and a poly-sialytransferase and methods to use the fusion proteins for production of poly-sialylated end products, e.g. oligosaccharides and glycoproteins.
    Type: Application
    Filed: January 30, 2007
    Publication date: October 1, 2009
    Applicant: National Research Council of Canada
    Inventors: Warren Wakarchuk, Michel Gilbert
  • Publication number: 20090215116
    Abstract: The invention relates to ?-1,3-N-acetylgalactosaminyltransferase polypeptides, nucleic acids that encode the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: April 7, 2006
    Publication date: August 27, 2009
    Applicant: National Research Council of Canada
    Inventors: Michel Gilbert, Warren Wakarchuk, Scott Houliston
  • Publication number: 20070048854
    Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.
    Type: Application
    Filed: October 11, 2006
    Publication date: March 1, 2007
    Inventors: Michel Gilbert, Warren Wakarchuk
  • Publication number: 20060166317
    Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.
    Type: Application
    Filed: December 11, 2003
    Publication date: July 27, 2006
    Applicant: National Research Council of Canada
    Inventors: Michel Gilbert, Warren Wakarchuk
  • Publication number: 20050227248
    Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.
    Type: Application
    Filed: October 8, 2004
    Publication date: October 13, 2005
    Applicant: National Research Council of Canada
    Inventors: Michel Gilbert, Warren Wakarchuk
  • Publication number: 20050084891
    Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.
    Type: Application
    Filed: October 8, 2004
    Publication date: April 21, 2005
    Applicant: National Research Council of Canada
    Inventors: Michel Gilbert, Warren Wakarchuk
  • Publication number: 20050064550
    Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.
    Type: Application
    Filed: April 22, 2004
    Publication date: March 24, 2005
    Applicant: National Research Council of Canada
    Inventors: Michel Gilbert, Warren Wakarchuk
  • Publication number: 20050048630
    Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.
    Type: Application
    Filed: October 8, 2004
    Publication date: March 3, 2005
    Applicant: National Research Council of Canada
    Inventors: Michel Gilbert, Warren Wakarchuk