Patents by Inventor Warren William WAKARCHUK

Warren William WAKARCHUK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR SIALYLATED MUCIN-TYPE O-GLYCOSYLATION OF THERAPEUTIC PROTEINS
    Publication number: 20220380785
    Abstract: Provided herein are enzymatic compositions for protein O-glycosylation and sialylation, methods and systems associated therewith. In particular, the composition for in vivo sialylation of therapeutic proteins. The composition comprises a polypeptide N-acetylgalactosaminyltransferase; a ?-1,3-galactosyltransferase; an UDP-Glc/GlcNAc 4-epimerase; a disulfide bond isomerase; and an ?-2,3-sialyltransferase or an ?-2,6-sialyltransferase. Furthermore, provided herein are compositions for efficient and complete O-glycosylation and di-sialylation of therapeutic proteins.
    Type: Application
    Filed: November 1, 2020
    Publication date: December 1, 2022
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Stephen G. WITHERS, Lyann SIM, Warren William WAKARCHUK