Abstract: A cellular microcompartment comprising: at least one layer of cells, an outer layer of hydrogel, and a fibrin mesh arranged between the outer layer of hydrogel and said layer of cells, the cellular microcompartment being compliant with regulations for Good Manufacturing Practices (GMP) and suitable for clinical applications, as well as methods for preparing the cellular microcompartment, and methods in which the cellular microcompartment is used for production of cells and/or tissues, including a large-scale production.