Patents by Inventor Wataru Akahata

Wataru Akahata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VIRUS-LIKE PARTICLES AND METHODS OF USE
    Publication number: 20190153041
    Abstract: The invention features modified alphavirus or flavivirus virus-like particles (VLPs). The invention provides methods, compositions, and kits featuring the modified VLPs. The invention also features methods for enhancing production of modified VLPs for use in the prevention or treatment of alphavirus and flavivirus-mediated diseases. The invention also provides methods for delivering agents to a cell using the modified VLPs.
    Type: Application
    Filed: November 26, 2018
    Publication date: May 23, 2019
    Inventors: Gary J. Nabel, Srinivas Rao, Wataru Akahata
  • Method and composition for modulating immune response
    Patent number: 10166281
    Abstract: Provided is a method for modulating an immune response which is not derived from alphavirus infection comprising administering to a subject in need thereof an effective amount of a composition comprising an alphavirus virus like particle.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: January 1, 2019
    Assignee: VLP Therapeutics, LLC
    Inventors: Wataru Akahata, Ryuji Ueno
  • Virus-like particles and methods of use
    Patent number: 10138277
    Abstract: The invention features modified alphavirus or flavivirus virus-like particles (VLPs). The invention provides methods, compositions, and kits featuring the modified VLPs. The invention also features methods for enhancing production of modified VLPs for use in the prevention or treatment of alphavirus and flavivirus-mediated diseases. The invention also provides methods for delivering agents to a cell using the modified VLPs.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: November 27, 2018
    Assignee: The United States of America as Represented by the Secretary Department of Health and Human Services
    Inventors: Gary J. Nabel, Srinivas Rao, Wataru Akahata
  • Flavivirus virus like particle
    Patent number: 10098943
    Abstract: Provided is a virus like particle comprising one or more flavivirus structural proteins, and a composition or vaccine comprising thereof, its use in the prevention or treatment of flavivirus infection. The flavivirus structural protein contains at least one amino acid alteration in the envelope region. Examples of flavivirus contains dengue virus.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: October 16, 2018
    Assignee: VLP Therapeutics, LLC
    Inventors: Wataru Akahata, Ryuji Ueno
  • Virus like particle comprising modified envelope protein E3
    Patent number: 9969986
    Abstract: A virus like particle comprising a viral structural protein which comprises modified envelope protein E3. The viral structural protein may be that derived from or alphavirus or flavivirus. Especially, the viral structural protein may be derived from Chikungunya virus or Venezuelan equine encephalitis virus.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: May 15, 2018
    Assignee: VLP Therapeutics, LLC
    Inventors: Wataru Akahata, Ryuji Ueno
  • ZIKA VIRUS VIRUS LIKE PARTICLE
    Publication number: 20170252425
    Abstract: Provided is a virus like particle comprising one or more zika virus structural proteins, and a composition or vaccine comprising thereof, its use in the prevention or treatment of zika virus disease. The zika virus structural protein contains at least one amino acid alteration in the envelope protein.
    Type: Application
    Filed: March 3, 2017
    Publication date: September 7, 2017
    Applicant: VLP Therapeutics, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • VIRUS LIKE PARTICLE COMPRISING PD-1 ANTIGEN OR PD-1 LIGAND ANTIGEN
    Publication number: 20170233450
    Abstract: The present invention provides a virus like particle comprising a virus structural protein and an antigen derived from PD-1 or a ligand of PD-1, and a composition or kit comprising thereof, its use in immune response etc.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 17, 2017
    Applicant: VLP Therapeutics, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • Virus like particle comprising PD-1 antigen or PD-1 ligand antigen
    Patent number: 9637532
    Abstract: The present invention provides a virus like particle comprising a virus structural protein and an antigen derived from PD-1 or a ligand of PD-1, and a composition or kit comprising thereof, its use in immune response etc.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: May 2, 2017
    Assignee: VLP Therapeutics, LLC
    Inventors: Wataru Akahata, Ryuji Ueno
  • VIRUS-LIKE PARTICLES AND METHODS OF USE
    Publication number: 20170073377
    Abstract: The invention features modified alphavirus or flavivirus virus-like particles (VLPs). The invention provides methods, compositions, and kits featuring the modified VLPs. The invention also features methods for enhancing production of modified VLPs for use in the prevention or treatment of alphavirus and flavivirus-mediated diseases. The invention also provides methods for delivering agents to a cell using the modified VLPs.
    Type: Application
    Filed: September 29, 2016
    Publication date: March 16, 2017
    Inventors: Gary J. NABEL, Srinivas RAO, Wataru AKAHATA
  • METHOD AND COMPOSITION FOR MODULATING IMMUNE RESPONSE
    Publication number: 20170065703
    Abstract: Provided is a method for modulating an immune response which is not derived from alphavirus infection comprising administering to a subject in need thereof an effective amount of a composition comprising an alphavirus virus like particle.
    Type: Application
    Filed: September 2, 2016
    Publication date: March 9, 2017
    Applicant: VLP Therapeutics, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • MALARIA VACCINE
    Publication number: 20170035871
    Abstract: The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in medicine, particularly in the prevention or treatment of malaria infections.
    Type: Application
    Filed: October 21, 2016
    Publication date: February 9, 2017
    Applicant: VLP Therapeutics, LLC
    Inventors: Ryuji UENO, Wataru AKAHATA
  • Malaria vaccine
    Patent number: 9512190
    Abstract: The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in medicine, particularly in the prevention or treatment of malaria infections.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: December 6, 2016
    Assignee: VLP Thereapeutics, LLC
    Inventors: Ryuji Ueno, Wataru Akahata
  • Virus-like particles and methods of use
    Patent number: 9487563
    Abstract: The invention features modified alphavirus or flavivirus virus-like particles (VLPs). The invention provides methods, compositions, and kits featuring the modified VLPs. The invention also features methods for enhancing production of modified VLPs for use in the prevention or treatment of alphavirus and flavivirus-mediated diseases. The invention also provides methods for delivering agents to a cell using the modified VLPs.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: November 8, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Gary J. Nabel, Srinivas Rao, Wataru Akahata
  • VIRUS LIKE PARTICLE COMPOSITIONS AND METHODS OF USE
    Publication number: 20160303221
    Abstract: The invention features compositions and methods for the prevention or treatment of one or more strains of Chikungunya virus, as well as other alphavirus-mediated diseases.
    Type: Application
    Filed: May 3, 2016
    Publication date: October 20, 2016
    Inventors: Gary J. NABEL, Wataru AKAHATA, Srinivas RAO
  • VIRUS LIKE PARTICLE COMPRISING MODIFIED ENVELOPE PROTEIN E3
    Publication number: 20160200775
    Abstract: A virus like particle comprising a viral structural protein which comprises modified envelope protein E3. The viral structural protein may be that derived from or alphavirus or flavivirus. Especially, the viral structural protein may be derived from Chikungunya virus or Venezuelan equine encephalitis virus.
    Type: Application
    Filed: January 7, 2016
    Publication date: July 14, 2016
    Applicant: VLP Therapeutics, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • Virus-like particles (VLPs) prepared from chikungunya virus structural proteins
    Patent number: 9353353
    Abstract: The invention features compositions and methods for the prevention or treatment of one or more strains of Chikungunya virus, as well as other alphavirus-mediated diseases.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: May 31, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Gary J. Nabel, Wataru Akahata, Srinivas Rao
  • VIRUS LIKE PARTICLE COMPOSITION
    Publication number: 20160090403
    Abstract: The present invention provides a particle comprising a polypeptide and at least one antigen, and a composition comprising thereof.
    Type: Application
    Filed: December 8, 2015
    Publication date: March 31, 2016
    Applicant: VLP Therapeutics, LLC
    Inventors: Ryuji UENO, Wataru AKAHATA
  • Flavivirus virus like particle
    Publication number: 20160074501
    Abstract: Provided is a virus like particle comprising one or more flavivirus structural proteins, and a composition or vaccine comprising thereof, its use in the prevention or treatment of flavivirus infection. The flavivirus structural protein contains at least one amino acid alteration in the envelope region. Examples of flavivirus contains dengue virus.
    Type: Application
    Filed: September 10, 2015
    Publication date: March 17, 2016
    Applicant: VLP THERAPEUTICS, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • VIRUS LIKE PARTICLE COMPRISING MODIFIED ENVELOPE PROTEIN E3
    Publication number: 20160040134
    Abstract: A virus like particle comprising a viral structural protein which comprises modified envelope protein E3. The viral structural protein may be that derived from or alphavirus or flavivirus. Especially, the viral structural protein may be derived from Chikungunya virus or Venezuelan equine encephalitis virus.
    Type: Application
    Filed: August 7, 2015
    Publication date: February 11, 2016
    Applicant: VLP THERAPEUTICS, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • Virus like particle composition
    Patent number: 9249191
    Abstract: The present invention provides a particle comprising a polypeptide and at least one antigen, and a composition comprising thereof.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: February 2, 2016
    Assignee: VLP Therapeutics, LLC
    Inventors: Ryuji Ueno, Wataru Akahata