Patents by Inventor Wataru Ebina

Wataru Ebina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
    Patent number: 11891625
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: February 6, 2024
    Inventors: Derrick J. Rossi, Wataru Ebina, Morag Stewart, Paula Gutierrez-Martinez, Lee L Rubin, Lance Davidow
  • METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE
    Publication number: 20200248143
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Application
    Filed: April 21, 2020
    Publication date: August 6, 2020
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derrick J. ROSSI, Wataru EBINA, Morag STEWART, Paula GUTIERREZ-MARTINEZ, Lee L. RUBIN, Lance DAVIDOW
  • Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
    Patent number: 10669528
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 2, 2020
    Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derrick J. Rossi, Wataru Ebina, Morag Stewart, Paula Gutierrez-Martinez, Lee L. Rubin, Lance Davidow
  • METHODS AND COMPOSITIONS RELATING TO HOMOLOGY-DIRECTED REPAIR
    Publication number: 20200149038
    Abstract: The methods and compositions described herein relate to improvements in the efficiency and/or accuracy of targeted alterations to a nucleic acid sequence, e.g, gene editing technologies, by creating nick or DSB in a target nucleic in the presence of template molecule, an inhibitor of NHEJ and an agonist of HDR. In contrast to earlier technologies, these methods are not specific to each template and/or target sequence while retaining specificity of the editing itself.
    Type: Application
    Filed: March 28, 2017
    Publication date: May 14, 2020
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Derrick J. ROSSI, Bruna PAULSEN, Pankaj K. MANDAL, Wataru EBINA, Paula GUTIERREZ-MARTINEZ
  • EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA)
    Publication number: 20200000881
    Abstract: Aspects of the invention described herein relate to synthetic, modified RNAs and their use in vivo to modulate gene expression. Aspects of the invention further relate to the use of these synthetic, modified RNAs in myocytes, cardiomyoctes, and tumors.
    Type: Application
    Filed: July 23, 2019
    Publication date: January 2, 2020
    Applicants: THE GENERAL HOSPITAL CORPORATION, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Kenneth R. Chien, Leon M. Ptaszek, Kathy Oi-Lan Lui, Lior Zangi, Wataru Ebina, Derrick J. Rossi
  • METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION
    Publication number: 20190119642
    Abstract: Described herein are methods and compositions relating to expanding, enriching, and/or maintaining a population of hematopoietic stem cells ex vivo. In some embodiments, the methods and compositions can relate to a combination of two or more agents, e.g.
    Type: Application
    Filed: March 15, 2017
    Publication date: April 25, 2019
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Derrick J. ROSSI, Wataru EBINA
  • EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA)
    Publication number: 20190117733
    Abstract: Aspects of the invention described herein relate to synthetic, modified RNAs and their use in vivo to modulate gene expression. Aspects of the invention further relate to the use of these synthetic, modified RNAs in myocytes, cardiomyoctes, and tumors.
    Type: Application
    Filed: June 22, 2018
    Publication date: April 25, 2019
    Applicants: THE GENERAL HOSPITAL CORPORATION, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Kenneth R. Chien, Leon M. Ptaszek, Oi-Lan Lui, Lior Zangi, Wataru Ebina, Derrick J. Rossi
  • Efficient protein expression in vivo using modified RNA (MOD-RNA)
    Patent number: 10086043
    Abstract: Aspects of the invention described herein relate to synthetic, modified RNAs and their use in vivo to modulate gene expression. Aspects of the invention further relate to the use of these synthetic, modified RNAs in myocytes, cardiomyoctes, and tumors.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: October 2, 2018
    Assignees: THE GENERAL HOSPITAL CORPORATION, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Kenneth R. Chien, Leon M. Ptaszek, Oi-Lan Lui, Lior Zangi, Wataru Ebina, Derrick J. Rossi
  • METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE
    Publication number: 20180187156
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Application
    Filed: June 24, 2016
    Publication date: July 5, 2018
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derrick J. ROSSI, Wataru EBINA, Morag STEWART, Paula GUTIERREZ-MARTINEZ, Lee RUBIN, Lance DAVIDOW
  • EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA)
    Publication number: 20140073687
    Abstract: Aspects of the invention described herein relate to synthetic, modified RNAs and their use in vivo to modulate gene expression. Aspects of the invention further relate to the use of these synthetic, modified RNAs in myocytes, cardiomyoctes, and tumors.
    Type: Application
    Filed: March 12, 2012
    Publication date: March 13, 2014
    Applicants: IMMUNE DISEASE INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATION
    Inventors: Kenneth R. Chien, Leon M. Ptaszek, Kathy Oi-Lan Lui, Lior Zangi, Wataru Ebina, Derrick J. Rossi