Abstract: An electrophoresis chip capable of suppressing the drift phenomenon is provided. The electrophoresis chip includes a channel which separates a sample by isoelectric focusing electrophoresis and a plurality of columnar structures disposed all over the channel. The columnar structures are disposed such that the flow of a sample solution, which moves in the longitudinal direction of the channel, is disturbed.

Abstract: Liquid contact structure 1 includes lyophilic surface 2 which is provided with a plurality of convex structures 3 and which is adapted to come into contact with a predetermined liquid. Surface 2 has lyophilicity that varies depending on regions of 2 surface according to a difference in a surface area multiplication factor which is caused by convex structures 3, wherein surface 2 is formed to have highest lyophilicity within predetermined region 4 on surface 2.

Abstract: An object of the present invention is to provide a technique through which a raster scan program which can obtain a signal which is more excellent in strength and sensitivity than a signal which is areally averaged within a well formed in a channel in an electrophoresis chip can be programmed. A raster scan system of the present invention is a raster scan system which raster-scans a sample accommodation portion of a chip through a laser, at least a matrix is in the sample accommodation portion, and an irradiation frequency for each laser irradiation location of the sample accommodation portion of the chip is determined based on an irradiation frequency dependence of a signal strength for each irradiation location of the sample accommodation portion which is obtained by irradiating a laser to the sample accommodation portion.

Abstract: After a sample is previously separated into plural components in a channel formed in a microchip (353), the channel is irradiated along a separation direction with a laser beam from a laser oscillator (361) to sequentially ionize each fraction separated in the channel. The ionized fraction is detected by a mass spectrometry unit (363) and analyzed by an analytical result analyzing unit (371). The analytical result is stored in a memory (369) while associated with position information in a driver control unit (367) and information on laser beam irradiation condition in a laser control unit (373), and the analytical result is imaged by an imaging unit (375). The imaged analytical result is displayed on a display (377).

Abstract: When a predetermined voltage is applied between electrodes (302), metal ions deposit in a solid electrolyte (308), and thereby a conduction channel (310) is formed therein. The solid electrolyte switch (300) is thus turned on. Because this deposition mechanism is reversible, application of reverse voltage between the electrodes of the solid electrolyte switch (300) already turned on makes the deposited metal atoms to migrate in the solid electrolyte to thereby thin the conduction channel 300, thereby the channel finally disappears, and the solid electrolyte switch (300) is turned into a non-conductive state. Use of this switch successfully realizes an IC tag which can automatically be nullified without artificial nullification.

Abstract: Disclosed is a donepezil-containing transdermally absorbable preparation which develops reduced adverse side effects and shows a satisfactory level of therapeutic effect. The preparation comprises an adhesive and a donepezil component (containing crystalline donepezil having type-B crystal polymorphism) and/or a salt thereof, wherein the donepezil component or the salt thereof is contained in an amount of 9 to 50% by mass relative to the total weight of the adhesive. The preparation (particularly, one having a non-aqueous adhesive layer) shows an excellent penetration of donepezil and/or a salt thereof into the skin, retains good stability of the active ingredient therein, and is remarkably reduced in local stimulation and adverse side effects.

Abstract: An electrophoresis chip is provided with a channel that is filled with a solution in which a sample is dissolved, the electrophoresis chip being configured to carry out electrophoresis by applying voltage along the channel in a state in which the channel is hermetically sealed to separate the sample in the channel, and after this electrophoresis is performed, to carry out mass spectrometry by scanning a laser along the channel in a state in which the channel is open to an environment in which gas is present. A pattern is formed on the bottom surface of the channel to hold the solution as droplets. This pattern is made into a pattern in which hydrophilic areas are surrounded by hydrophobic areas and side-walls of the channel.

Abstract: A diagnosis supporting system (10) includes a diagnosis data obtaining unit (20) that obtains diagnosis data in which a movement parameter reflecting a movement speed of each component in separating a sample collected from a test subject into plural components with a chip (12) and a character of each component is in correspondence, a parameter storing unit (34) that stores the movement parameter of a characteristic component showing a state of suffering from a specific disease in correspondence with the disease, a relationship data storing unit (35) that stores relationship data showing a relationship between the character of the characteristic component and a possibility of suffering from a specific disease, a detecting unit (21) that detects the characteristic component from the diagnosis data based on the movement parameter of the characteristic component and the movement parameter of the diagnosis data by making reference to the parameter storing unit (34), and an inference processing unit (22) that infer

Abstract: With the object of realizing a microchip that allows drying and fixing of a substance that is the object of analysis in a shorter time while maintaining the separation capabilities of a separation operation, a microchip used to implement a separation operation of an analysis sample without contamination or spillage is composed of a substrate and a cover, the substrate being provided with a trench-shaped channel in its upper surface and substrate reservoirs that are linked with this channel, and the cover hermetically sealing the upper surface of the channel, attachable to or detachable from the substrate, and provided with through-holes formed at positions corresponding to the substrate reservoirs, cover reservoirs that are formed on the inner sides of the through-holes for holding liquid that is introduced when the cover is in the state of hermetically sealing the upper surface of the channel, and partitions that are formed on the bottom surfaces of the cover reservoirs.

Abstract: A sample which contains protein is stably maintained in a liquid state during electrophoresis. Electrophoresis chip 1 includes substrate 2, channels 5a to 5d which is provided on surface 3 of substrate 2 and which has openings 4a to 4d at the top thereof, wherein a sample solvent is adapted to be supplied to the channel, and evaporation inhibitor reservoirs 8a, 8b for storing an evaporation inhibitor for the sample solvent, the reservoir being provided independently of channel 5a to 5d and being spatially connected to opening 4a to 4d of channel 5a to 5d.

Abstract: A dual-mode acoustic wave resonator (7a) having a resonance mode inter-coupler (6) is disposed across narrow voids (4, 5) from an input electrode (2) and an output electrode (3). They are supported for vibrations on a substrate by conductive posts (27, 28, 29) and a power supply pad (3). Opposing electrodes (10, 11, 21, 23) are formed below the input and output electrodes (2, 3), resonator (7a), and resonance mode inter-coupler (6) across narrow gaps. As a voltage of a power supply (25) is changed, a distortion of the resonator (7a) changes due to an electrostatic force, causing a change in the center resonance frequency. As voltages of power supplies (16, 17) are changed, distortions of the input and output electrodes (2, 3) change to cause a change in the opposing areas of end faces of the input and output electrodes to the resonator (7a). This causes a change in the situation of exchanging energy between the input and output electrodes and the resonator (7a) to change the external Q-value.

Abstract: A reaction apparatus (10) includes a substrate (12) and a plurality of columnar members (14) formed on the substrate (12). Oligonucleotides for immobilization (16) having sequences complementary to sequences of both ends of a starting template DNA (18) is adhered on the surfaces of the substrate (12) and the columnar members (14). The starting template DNA (18) can be immobilized over the adjacent columnar members (14) by introducing the starting template DNA (18) under the elongated condition. PCR is conducted in such condition.

Abstract: The present invention provides a technique for precisely controlling the lyophilic/lyophobic property of a material surface using a simple construction, a method of utilizing this technique to make anisotropic the level of lyophilic or lyophobic property of a material surface having its lyophilic/lyophobic property controlled, and a method of applying the technique to retain a liquid in a predetermined region of the material surface. For example, liquid retaining portion 103 consists of a regular recess and protrusion structure, and flat part 104 consists of a flat surface surrounding the outer periphery of liquid retaining portion 103 are formed on a surface of substrate 101. The recess and protrusion structure is formed so that the surface area of recess and protrusion structure of liquid retaining portion 103 is larger than the area of the region in which liquid retaining portion 103 is formed and so that the multiplication factor of the surface area has a desired value.

Abstract: Liquid-keeping part is formed in channel 107 of chip 111 for electrophoresis. Electrophoresis is carded out by using electrophoresis chamber 118 holding chip 111 for electrophoresis in its inside and having a system of controlling temperature of electrophoretic chip 111 by putting humidity-controlling liquid 117.

Abstract: A liquid sample (104) introduced in a main flow passage (101) is held in a dam portion (105), and a trigger liquid (106) is filled in a trigger flow passage (102). In this state, the trigger liquid (106) is further introduced at desired timing into the trigger flow passage (102) so that the front end portion of the level of the trigger liquid (106) is advanced and the front end portion is brought to be into contact with the dam portion (105). This causes the liquid sample (104) to move to the right (downstream side) in the figure, resulting in the liquid sample (104) flowing out to the downstream side of the main flow passage (101). This means that the trigger liquid (106) provides priming to realize a liquid switch.

Abstract: When a predetermined voltage is applied between electrodes (302), metal ions deposit in a solid electrolyte (308), and thereby a conduction channel (310) is formed therein. The solid electrolyte switch (300) is thus turned on. Because this deposition mechanism is reversible, application of reverse voltage between the electrodes of the solid electrolyte switch (300) already turned on makes the deposited metal atoms to migrate in the solid electrolyte to thereby thin the conduction channel 300, thereby the channel finally disappears, and the solid electrolyte switch (300) is turned into a non-conductive state. Use of this switch successfully realizes an IC tag which can automatically be nullified without artificial nullification.

Abstract: A radio receiver disclosed is composed of a signal processing part, which includes a receive band pass filter 2 and a receive low noise amplifier 3, to process receive signal and discharge gas with time, the signal processing part being cooled by the cooling means 6, wherein the radio receiver is provided with an airtight container 10 that operates as inner sealing means to seal the receive band pass filter 2 and the receive low noise amplifier 3 to retain the gas, and a vacuum container 5 that operates as outer sealing means to seal in vacuum the airtight container 10 such that an interspace 12 between that and the airtight container 10 forms a vacuum insulating space to insulate in vacuum the airtight container 10 from outside.

Abstract: A dual-mode acoustic wave resonator (7a) having a resonance mode inter-coupler (6) is disposed across narrow voids (4, 5) from an input electrode (2) and an output electrode (3). They are supported for vibrations on a substrate by conductive posts (27, 28, 29) and a power supply pad (3). Opposing electrodes (10, 11, 21, 23) are formed below the input and output electrodes (2, 3), resonator (7a), and resonance mode inter-coupler (6) across narrow gaps. As a voltage of a power supply (25) is changed, a distortion of the resonator (7a) changes due to an electrostatic force, causing a change in the center resonance frequency. As voltages of power supplies (16, 17) are changed, distortions of the input and output electrodes (2, 3) change to cause a change in the opposing areas of end faces of the input and output electrodes to the resonator (7a). This causes a change in the situation of exchanging energy between the input and output electrodes and the resonator (7a) to change the external Q-value.

Abstract: A channel formed on a chip is opened without contaminating contents of the channel. Channels (107a) and (107b) provided on a substrate (103) are covered by pressing a lid (113) composed of a resin layer (102) and a plate-like lid (101) to a surface of the substrate (103). A fixing device has a retainer plate (104), which retains the plate-like lid (101) of a chip (112), a board (108) on which the substrate (103) is placed, and a screw (106). When covering the channels (107a) and (107b), the screw (106) is fastened and the lid (113) is pressed to the substrate (103) to be fixed. And, when opening an upper portion of the channels (107a) and (107b), the screw (106) is turned upward and a pressure is released, and the lid (113) is removed from the upper potion of the substrate (103).

Abstract: A semi-rigid cable coaxially includes a brass wire (1) having a silver-plated layer (2) formed by plating silver having a high conductivity, a dielectric body (3) prepared by using fluorocarbon resin, a polymer film (4) having a conductive film (inner layer of an outer conductor) (5) formed by deposition, and a metal pipe (6) having a low thermal conductivity as an outer layer of the outer conductor. The polymer film (4) is inserted into the metal pipe (6) with the conductive film (5) toward the outer circumference so that the conductive film (5) is electric contact with the metal pipe (6). The conductive film (5) has a thickness in a range not smaller than 1 micron and not greater than 10 microns.