Abstract: [PROBLEM] The problem to be solved by the invention is to provide a novel pharmaceutical use of a JAK inhibitor. [SOLUTION MEANS] A therapeutic or preventive agent for a skin disease selected from the group consisting of senile xerosis, asteatosis, eczema and contact dermatitis, containing a JAK inhibitor as an active ingredient. [EFFECT] The followings are found: a JAK inhibitor increases the expression amounts of filaggrin, loricrin, involucrin and ?-defensin 3 as skin barrier function-related proteins; a JAK inhibitor significantly increases NMF production in a Tape Stripping-treated mouse; and a JAK inhibitor significantly accelerates a reduction in TEWL in a dry skin mouse model, namely improves the skin barrier function. The JAK inhibitor can be used as an active ingredient of a therapeutic or preventive agent for skin diseases such as senile xerosis, asteatosis, eczema, contact dermatitis, ichthyosis vulgaris, Netherton syndrome, type B peeling skin syndrome, etc.

Abstract: There is provided a method for manufacturing a galvanized steel sheet that has low sliding resistance in press forming and good degreasing property even under severe alkaline degreasing treatment conditions due to low temperature and short process line length. An oxide layer formed on the surface of a galvanized steel sheet is subjected to neutralization treatment using an alkaline aqueous solution containing 0.01 g/L or more of P ions and 0.01 g/L or more of colloid dispersed particles, wherein the alkaline aqueous solution preferably contains at least one phosphorus compound selected from phosphates, pyrophosphates, and triphosphates and at least one type of colloid dispersed particles selected from Ti, silica, Pt, Pd, Zr, Ag, Cu, Au, and Mg.

Abstract: An object of the present invention is to make it possible, without necessitating an alkali pretreatment, to form a zinc oxide layer having excellent sliding properties on a hot dip galvanized steel sheet not subjected to alloying after galvanizing and thus having a relatively low degree of surface activity. Another object of the present invention is to make it possible to manufacture a hot dip galvanized steel sheet having higher area ratio of Zn oxide layer formed on a coating surface and larger thickness of the Zn oxide layer.

Abstract: There is provided a method for manufacturing a galvanized steel sheet that has low sliding resistance in press forming and good degreasing property even under severe alkaline degreasing treatment conditions due to low temperature and short process line length. An oxide layer formed on the surface of a galvanized steel sheet is subjected to neutralization treatment using an alkaline aqueous solution containing 0.01 g/L or more of P ions and 0.01 g/L or more of colloid dispersed particles, wherein the alkaline aqueous solution preferably contains at least one phosphorus compound selected from phosphates, pyrophosphates, and triphosphates and at least one type of colloid dispersed particles selected from Ti, silica, Pt, Pd, Zr, Ag, Cu, Au, and Mg.

Abstract: A process of manufacturing high-strength cold rolled steel sheets containing 0.5 to 2.0 mass % silicon includes a pickling step of thermally annealing a steel sheet in a non-oxidizing atmosphere and thereafter pickling the steel sheet to dissolve away 0.5 g/m2 to less than 2.0 g/m2 of the steel sheet, and an electroplating step of electroplating the surface of the pickled steel sheet with zinc under such conditions that a coating mass of 100 to 5000 mg/m2 is obtained.

Abstract: A zinc-based metal plated steel sheet is excellent in tribological properties during press forming. An oxide layer containing crystalline 3Zn(OH)2.ZnSO4.xH2O is formed on a plated surface. The oxide layer has a thickness of 10 nm or more. The crystalline oxide layer is composed of 3Zn(OH)2.ZnSO4.3-5H2O.

Abstract: An object of the present invention is to make it possible, without necessitating an alkali pretreatment, to form a zinc oxide layer having excellent sliding properties on a hot dip galvanized steel sheet not subjected to alloying after galvanizing and thus having a relatively low degree of surface activity. Another object of the present invention is to make it possible to manufacture a hot dip galvanized steel sheet having higher area ratio of Zn oxide layer formed on a coating surface and larger thickness of the Zn oxide layer.

Abstract: A hot dip galvannealed steel sheet, which is a plated steel sheet, the plated sheet including an oxide layer being formed on the surface of the plated steel sheet, having an average thickness of 10 nm or more, and containing Zn and at least one element selected from the group consisting of Zr, Ti and Sn.

Abstract: A method of manufacturing a hot dip galvannealed steel sheet, including the steps of: subjecting a steel sheet to hot dip galvanizing to manufacture a hot dip galvanized steel sheet; heating the hot dip galvanized steel sheet for alloying; subjecting the hot dip galvanized steel sheet to temper rolling; bringing the temper-rolled hot dip galvanized steel sheet into contact with an acid solution containing at least one ion selected from the group consisting of Zr ions, Ti ions, and Sn ions to thereby form an acid solution film on the surface of the steel sheet; after completion of the contact, a state where the acid solution film is formed on the surface of the steel sheet is held for at least 1 second; and washing with water the hot dip galvanized steel sheet after holding, to thereby form a Zn oxide layer having a thickness of 10 nm or more on the surface of the galvanized steel sheet.

Abstract: A zinc-based metal plated steel sheet is excellent in tribological properties during press forming. An oxide layer containing crystalline 3Zn(OH)2·ZnSO4·xH2O is formed on a plated surface. The oxide layer has a thickness of 10 nm or more. The crystalline oxide layer is composed of 3Zn(OH)2·ZnSO4·3-5H2O.

Abstract: A zinc-based metal plated steel sheet is excellent in tribological properties during press forming. An oxide layer containing crystalline 3Zn(OH)2.ZnSO4. xH2O is formed on a plated surface. The oxide layer has a thickness of 10 nm or more. The crystalline oxide layer is composed of 3Zn(OH)2.ZnSO4.3-5H2O.

Abstract: A zinc-based metal plated steel sheet is excellent in tribological properties during press forming. An oxide layer containing crystalline 3Zn(OH)2.ZnSO4.xH2O is formed on a plated surface. The oxide layer has a thickness of 10 nm or more. The crystalline oxide layer is composed of 3Zn(OH)2.ZnSO4.3-5H2O.

Abstract: The press formability of a galvanized steel sheet including an oxide film, which has a thickness of 10 nm to 100 nm, as a surface layer is nondestructively speedily evaluated.

Abstract: A method of manufacturing a hot dip galvannealed steel sheet, including the steps of: subjecting a steel sheet to hot dip galvanizing to manufacture a hot dip galvanized steel sheet; heating the hot dip galvanized steel sheet for alloying; subjecting the hot dip galvanized steel sheet to temper rolling; bringing the temper-rolled hot dip galvanized steel sheet into contact with an acid solution containing at least one ion selected from the group consisting of Zr ions, Ti ions, and Sn ions to thereby form an acid solution film on the surface of the steel sheet; after completion of the contact, a state where the acid solution film is formed on the surface of the steel sheet is held for at least 1 second; and washing with water the hot dip galvanized steel sheet after holding, to thereby form a Zn oxide layer having a thickness of 10 nm or more on the surface of the galvanized steel sheet.

Abstract: The press formability of a galvanized steel sheet including an oxide film, which has a thickness of 10 nm to 100 nm, as a surface layer is nondestructively speedily evaluated.

Abstract: A metallic hollow polygonal column having a smooth outer surface is immersed into a molten slag and immediately pulled up. The contact plane of the slag adhered on the outer surface of the hollow polygonal column is used as the analytical plane. The method of the hollow column has a thickness of 3 mm or greater.

Abstract: This invention provides a quantitative determination method capable of quickly determining a mean composition of oxide type inclusions and oxygen concentration of a metallic material such as a steel by using an optical emission spectrometer alone. This method comprises the steps of (1) conducting a plurality of times a discharge operation between the metallic material and an opposing electrode in an inert gas atmosphere to obtain an emission spectrochemical spectrum, (2) selecting a discharge in which at least either the oxygen A spectrum or the oxide-forming element spectrum exceed a predetermined intensity for each discharge operation, and (3) subtracting a background from the intensity of the oxygen spectrum and/or the intensity of the oxide-forming elements in the selected discharge, accumulating the balances to obtain a cumulative spectral intensity, and executing quantitative determination by a calibration curve method.

Abstract: A focusing lens having a focal length f is provided at a position spaced a distance L apart from a substance to be measured in the fluid state, the relationship between L and f is controlled, so that the formula:0.95f.ltoreq.L.ltoreq.1.05fis constantly satisfied, and the light emitted when a high output pulse laser irradiates the surface of the substance to be measured is analyzed spectroscopically so that the influence of variations on the surface of the substance to be measured can be avoided and a stabilized laser emission spectroscopically analysis on-line can be conducted as the substance to be measured flows.

Abstract: When a light emitted during the irradiation by a laser beam onto the surface of steel is spectrally separated and elements contained in the steel are analyzed quantitatively:an infrared pulse laser beam irradiates a sample such that an energy density on the surface of the sample becomes 2.0.times.10.sup.9 W/mm.sup.

Abstract: A zinc-based metal plated steel sheet is excellent in tribological properties during press forming. An oxide layer containing crystalline 3Zn(OH)2·ZnSO4·xH2O is formed on a plated surface. The oxide layer has a thickness of 10 nm or more. The crystalline oxide layer is composed of 3Zn(OH)2·ZnSO4·3-5H2O.