Patents by Inventor Wayne A. Bryden
Wayne A. Bryden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115157Abstract: Methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low-cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.Type: ApplicationFiled: December 7, 2023Publication date: April 11, 2024Applicant: Zeteo Tech, Inc.Inventors: Dapeng CHEN, Wayne A. BRYDEN, Michael McLOUGHLIN
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Publication number: 20240108770Abstract: Mobile decontamination systems and microwave assisted decontamination methods for decontaminating a variety of contaminated surfaces disposed external to the system. The systems and methods include treating the surfaces with benign chemical formulations followed by exposing to microwave irradiation for short periods of time to achieve at least 6-log reduction in biological contaminants including viruses and spores of B. anthracis, B. thuringiensis, and P. roqueforti. The formulations include a percarbonate and surfactant in water.Type: ApplicationFiled: December 5, 2023Publication date: April 4, 2024Applicant: Zeteo Tech, Inc.Inventors: Thomas McCreery, Wayne A. Bryden, Emily Caton
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Patent number: 11938243Abstract: Mobile decontamination systems and microwave assisted decontamination methods for decontaminating a variety of contaminated surfaces disposed external to the system are disclosed. The systems and methods comprise treating the surfaces with benign chemical formulations followed by exposing to microwave irradiation for short periods of time to achieve at least 6-log reduction in biological contaminants including viruses and spores of B. anthracis, B. thuringiensis, and P. roqueforti. The formulations comprise a percarbonate and surfactant in water.Type: GrantFiled: May 30, 2021Date of Patent: March 26, 2024Assignee: Zeteo Tech, Inc.Inventors: Thomas McCreery, Wayne A. Bryden, Emily Caton
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Publication number: 20240074673Abstract: Methods and devices to capture and analyze aerosolized particles in exhaled air including protein biomarkers and their truncated proteoforms characteristic of tuberculosis to enable rapid detection of diseases. Methods and systems to selectively capture aerosolized particles using a packed bed column. The captured particles are eluted using one or more solvents and analyzed using devices including MALDI-TOFMS.Type: ApplicationFiled: October 27, 2023Publication date: March 7, 2024Applicant: Zeteo Tech, Inc.Inventors: Dapeng Chen, Wayne A. Bryden, Michael McLoughlin, Kiana M. Kiser, Emily R. Caton, Caroline R. Haddaway
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Patent number: 11872322Abstract: Disclosed are microwave assisted methods and systems for decontaminating a variety of contaminated surfaces. The systems and methods comprise treating the surfaces with benign chemical formulations followed by exposing to microwave irradiation for short periods of time to achieve at least 6-log reduction in biological contaminants including spores of B. anthracis, B. thuringiensis, and P. roqueforti. Chemical formulations may comprise copper (II) chloride in water. The formulations may include a surfactant such as a polyethylene sorbitol ester surfactant.Type: GrantFiled: September 30, 2022Date of Patent: January 16, 2024Assignee: Zeteo Tech, Inc.Inventors: Thomas McCreery, Wayne A. Bryden
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Patent number: 11839463Abstract: Disclosed are methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.Type: GrantFiled: August 26, 2020Date of Patent: December 12, 2023Assignee: Zeteo Tech, Inc.Inventors: Dapeng Chen, Wayne A. Bryden, Michael McLoughlin
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Publication number: 20230245876Abstract: Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.Type: ApplicationFiled: April 11, 2023Publication date: August 3, 2023Applicant: Zeteo Tech, Inc.Inventors: Wayne A. BRYDEN, Charles J. CALL, Michael MCLOUGHLIN, Dapeng CHEN, Scott ECELBERGER, Nathaniel K. JONES, Steven STROHL
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Publication number: 20230157573Abstract: Disclosed are methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.Type: ApplicationFiled: August 26, 2020Publication date: May 25, 2023Applicant: Zeteo Tech, Inc.Inventors: Dapeng CHEN, Wayne A. BRYDEN, Michael McLOUGHLIN
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Patent number: 11658021Abstract: Disclosed are systems and methods to provide rapid and autonomous detection of analyte particles in gas and liquid samples. Disclosed are methods and devices for identifying biological aerosol analytes using MALDI-MS and chemical aerosol analytes using LDI and MALDI-MS using time-of-flight mass spectrometry (TOFMS).Type: GrantFiled: August 26, 2020Date of Patent: May 23, 2023Assignee: Zeteo Tech, Inc.Inventors: Wayne A. Bryden, Charles J. Call, Michael McLoughlin, Dapeng Chen, Scott Ecelberger, Nathaniel K. Jones, Steven Strohl, Gary Anderson
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Patent number: 11624749Abstract: Coating materials such as MALDI matrix solutions are aerosolized and are used to coat analyte particles in an acoustic coater. Methods and devices for coating analyte particles in real time are disclosed. The coating improves the detection and quantification of the analyte particles using analytical instruments such as an aerosol time of flight mass spectrometer.Type: GrantFiled: February 7, 2020Date of Patent: April 11, 2023Assignee: ZeteoTech, Inc.Inventors: Wayne A. Bryden, Charles J. Call
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Publication number: 20230039261Abstract: Disclosed are systems and methods to provide rapid and autonomous detection of analyte particles in gas and liquid samples. Disclosed are methods and devices for identifying biological aerosol analytes using MALDI-MS and chemical aerosol analytes using LDI and MALDI-MS using time-of-flight mass spectrometry (TOFMS).Type: ApplicationFiled: August 26, 2020Publication date: February 9, 2023Applicant: Zeteo Tech, Inc.Inventors: WAYNE A. BRYDEN, Charles J. CALL, Michael MCLOUGHLIN, Dapeng CHEN, Scott ECELBERGER, Nathaniel K. JONES, Steven STROHL, Gary ANDERSON
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Publication number: 20230042863Abstract: Disclosed are microwave assisted methods and systems for decontaminating a variety of contaminated surfaces. The systems and methods comprise treating the surfaces with benign chemical formulations followed by exposing to microwave irradiation for short periods of time to achieve at least 6-log reduction in biological contaminants including spores of B. anthracis, B. thuringiensis, and P. roqueforti. Chemical formulations may comprise copper (II) chloride in water. The formulations may include a surfactant such as a polyethylene sorbitol ester surfactant.Type: ApplicationFiled: September 30, 2022Publication date: February 9, 2023Applicant: Zeteo Tech, Inc.Inventors: Thomas McCreery, Wayne A. Bryden
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Patent number: 11524087Abstract: Disclosed are microwave assisted methods and systems for decontaminating a variety of contaminated surfaces. The systems and methods comprise treating the surfaces with benign chemical formulations followed by exposing to microwave irradiation for short periods of time to achieve at least 6-log reduction in biological contaminants including spores of B. anthracis, B. thuringiensis, and P. roqueforti. Chemical formulations may comprise copper (II) chloride in water. The formulations may include a surfactant such as a polyethylene sorbitol ester surfactant.Type: GrantFiled: March 22, 2020Date of Patent: December 13, 2022Assignee: Zeteo Tech, Inc.Inventors: Thomas McCreery, Wayne A. Bryden
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Publication number: 20220386893Abstract: Methods and devices to capture and analyze aerosolized particles such as protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of diseases are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using one or more solvents and analyzed using devices including mass spectrometry.Type: ApplicationFiled: August 11, 2022Publication date: December 8, 2022Applicant: Zeteo Tech Inc.Inventors: Dapeng Chen, Wayne A. Bryden, Michael McLoughlin
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Publication number: 20220322963Abstract: Disclosed are methods and devices for analyzing exhaled breath aerosols and exhaled breath condensates using various diagnostic tools that enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. Disclosed are methods and devices for analyzing exhaled breath aerosols and exhaled breath condensates for tuberculosis diagnosis using mass spectrometry, including MALDI-MS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.Type: ApplicationFiled: August 26, 2020Publication date: October 13, 2022Applicant: Zeteo Tech, Inc.Inventors: WAYNE A. BRYDEN, Charles J. Call, Robin Wood, Dapeng Chen
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Publication number: 20220323045Abstract: Methods and devices to capture and analyze aerosolized particles such as protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of diseases are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using one or more solvents and analyzed using devices including mass spectrometry.Type: ApplicationFiled: May 29, 2022Publication date: October 13, 2022Applicant: Zeteo Tech, Inc.Inventors: Dapeng Chen, Wayne A. Bryden, Michael McLoughlin
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Publication number: 20220252545Abstract: Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles, without pre-treatment using complex organic MALDI matrices. A continuous timing laser may be used to index aerosol particles, measure particle properties, and trigger a pulse ionization laser. Ionized fragments and optionally photons associated with each particle producing by the ionization laser may be analyzed using one or more detectors including a TOF-MS detector and an optical detector. The laser pulse may comprise a simultaneous IR and UV laser pulse when fragments comprise predominantly of UV chromophores. Unique spectral data associated with each indexed particle from each detector may be compiled using data fusion to generate compiled spectral data. Machine learning methods may be used to improve the prediction of composition over time.Type: ApplicationFiled: June 27, 2020Publication date: August 11, 2022Applicant: Zeteo Tech, Inc.Inventors: MICHAEL MCLOUGHLIN, Wayne A. Bryden, CHARLES J. CALL, Dapeng Chen
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Publication number: 20220096685Abstract: Disclosed are microwave assisted methods and systems for decontaminating a variety of contaminated surfaces. The systems and methods comprise treating the surfaces with benign chemical formulations followed by exposing to microwave irradiation for short periods of time to achieve at least 6-log reduction in biological contaminants including spores of B. anthracis, B. thuringiensis, and P. roqueforti. Chemical formulations may comprise copper (II) chloride in water. The formulations may include a surfactant such as a polyethylene sorbitol ester surfactant.Type: ApplicationFiled: March 22, 2020Publication date: March 31, 2022Applicant: Zeteo Tech, Inc.Inventors: Thomas McCreery, Wayne A. Bryden
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Publication number: 20220034854Abstract: Disclosed are methods and devices for analyzing aerosol particles in exhaled breath using diagnostic tools that enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. Disclosed are methods and devices for capturing exhaled breath aerosols in a packed bed column and analyzing exhaled captured breath aerosols for tuberculosis diagnosis.Type: ApplicationFiled: October 12, 2021Publication date: February 3, 2022Applicant: Zeteo Tech, Inc.Inventors: Dapeng Chen, Wayne A. Bryden, Michael McLoughlin
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Publication number: 20210290806Abstract: Mobile decontamination systems and microwave assisted decontamination methods for decontaminating a variety of contaminated surfaces disposed external to the system are disclosed. The systems and methods comprise treating the surfaces with benign chemical formulations followed by exposing to microwave irradiation for short periods of time to achieve at least 6-log reduction in biological contaminants including viruses and spores of B. anthracis, B. thuringiensis, and P. roqueforti. The formulations comprise a percarbonate and surfactant in water.Type: ApplicationFiled: May 30, 2021Publication date: September 23, 2021Applicant: Zeteo Tech, Inc.Inventors: Thomas McCreery, Wayne A. Bryden, Emily Caton