Abstract: This disclosure is drawn to substituted pyridine compounds and compositions, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing a neurological diseases.

Abstract: An example of a resin composition includes a free radical curable resin matrix including an acrylate and a siloxane, and a free radical photoinitiator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.

Abstract: Embodiments of the present disclosure relate to nucleotides labeled with photoswitchable compounds. Also provided herein are methods and kits of using these labeled nucleotides for sequencing applications.

Abstract: This disclosure is drawn to substituted pyridine compounds and compositions, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing a neurological diseases.

Abstract: In some examples, novel nanogel particles are described having dual functionality, temperature responsiveness and pH responsiveness. For nucleic acid sequencing, amplification primers are grafted to nanogel particles to form primer-grafted nanogel particles, and the primer-grafted nanogel particles are captured onto surfaces within a flow cell. Within flow cells such as used in SBS nucleic acid sequencing, each primer-grafted nanogel particle functions as a nano-well in the flow cell, thus eliminating the need for nano-wells in some examples.

Abstract: A method of manufacturing ceramic tape includes a step of directing a tape of partially-sintered ceramic into a furnace. The tape is partially-sintered such that grains of the ceramic are fused to one another yet the tape still includes at least 10% porosity by volume, where the porosity refers to volume of the tape unoccupied by the ceramic. The method further includes steps of conveying the tape through the furnace and further sintering the tape as the tape is conveyed through the furnace. The porosity of the tape decreases during the further sintering step.

Abstract: An example of a flow cell includes a base support, a reversibly swellable resin positioned over the base support, and a depression defined in the reversibly swellable resin. The reversibly swellable resin includes at least one hydrophilic monomer selected from the group consisting of a poly(ethylene glycol) based monomer, poly(propylene glycol) based monomer, and combinations thereof. The depression has a first opening dimension when the reversibly swellable resin is in a non-swelled stated and has a second opening dimension, that is smaller than the first opening dimension, when the reversibly swellable resin is in a swelled state.

Abstract: An example of an array includes a support, a cross-linked epoxy polyhedral oligomeric silsesquioxane (POSS) resin film on a surface of the support, and a patterned hydrophobic polymer layer on the cross-linked epoxy POSS resin film. The patterned hydrophobic polymer layer defines exposed discrete areas of the cross-linked epoxy POSS resin film, and a polymer coating is attached to the exposed discrete areas. Another example of an array includes a support, a modified epoxy POSS resin film on a surface of the support, and a patterned hydrophobic polymer layer on the modified epoxy POSS resin film. The modified epoxy POSS resin film includes a polymer growth initiation site, and the patterned hydrophobic polymer layer defines exposed discrete areas of the modified epoxy POSS resin film. A polymer brush is attached to the polymer growth initiation site in the exposed discrete areas.

Abstract: A method and apparatus for assisting in removing a wheels-on-ground type daughter cart from a mother cart, and a mother cart incorporating such a method and apparatus, utilize a daughter cart ejector apparatus mounted on a mother cart and having a selectively actuatable ejector element for urging the daughter cart to move out of engagement with the mother cart in an unloading direction. The ejector element is configured and operatively connected to bear against the daughter cart and apply force in a manner that assists in initiating movement of the daughter cart in the unloading direction and reorienting casters supporting the daughter cart on an underlying surface from a rolling orientation that is generally parallel to a transport direction of the mother cart, to a rolling orientation that is generally transverse to the transport direction and parallel to the unloading direction.

Abstract: An improved method for zero-voltage switching (ZVS) of a voltage-fed half-bridge using a variable dead band is provided. The duration of the dead band is determined dynamically and is precisely long enough to ensure the absence of shoot-through events while also minimizing or eliminating switching losses and reverse conduction losses. The method generally includes: (a) calculating the equivalent capacitance as seen by the current source charging the midpoint of the half-bridge; (b) calculating the ZVS charge requirement based on the link voltage and the equivalent capacitance; (c) calculating the charge delivered by the current source over time during a dead band vector, equating the result to the ZVS charge requirement, and solving for the ZVS time requirement at each commutation point over the switching cycle; and (d) updating the dead bands for each commutation of each half-bridge in the switched-mode power converter.

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

Abstract: A seed sampling system is provided comprising an automated seed loading assembly operable to singulate seeds from a plurality of seeds or enable loading of individually stored seeds and an automated seed sampling assembly comprising at least one sampling module operable to remove tissue samples from one of the singulated seeds. The system also includes an automated seed transport assembly comprising at least one retention member operable to transfer the singulated seeds from at least one elevator unit of the seed loading assembly to the at least one sampling module of the seed sampling assembly. In connection therewith, the at least one sampling module includes multiple sampling locations, each associated with a sampler, where the at least one sampling module is operable to remove tissue samples from seeds at one of sampling locations while another one of the sampling locations is cleaned to remove residual seed tissue therefrom.

Abstract: Methods, processes and devices are described for measuring a volatile content of a process stream that comprises volatile species, such as light hydrocarbons and/or H2S. The method can include introducing a stripping gas into a sample of the process stream to strip the volatiles therefrom and produce a gas phase comprising vaporized volatiles; detecting the vaporized volatiles in the gas phase to obtain a sample volatile content; and determining the volatile content of the process stream based on the sample volatile content. The method and device can be used to measure a light hydrocarbon content of froth treatment tailings in the context of removing such light hydrocarbons prior to flocculating and dewatering the tailings.

Abstract: A seed sampling system is provided comprising an automated seed loading assembly operable to singulate seeds from a plurality of seeds or enable loading of individually stored seeds and an automated seed sampling assembly comprising at least one sampling module operable to remove tissue samples from one of the singulated seeds. The system also includes an automated seed transport assembly comprising at least one retention member operable to transfer the singulated seeds from at least one elevator unit of the seed loading assembly to the at least one sampling module of the seed sampling assembly. In connection therewith, the at least one sampling module includes multiple sampling locations, each associated with a sampler, where the at least one sampling module is operable to remove tissue samples from seeds at one of sampling locations while another one of the sampling locations is cleaned to remove residual seed tissue therefrom.

Abstract: The present disclosure describes technologies that permit sensitive detection of nucleic acids of interest (i.e., nucleic acids whose nucleotide sequence is or includes a target sequence). Among other things the disclosure provides a system comprising: a plurality of nucleic acid molecules having different nucleotide sequences; a set of ligation oligonucleotides, comprising: a first ligation oligonucleotide whose nucleotide sequence includes a templating element and a first target hybridization element; and a second ligation oligonucleotide whose nucleotide sequence includes a second target hybridization element and optionally a second templating element; wherein the target hybridization elements bind to different portions of a common target site, to form a gapped nucleic acid strand susceptible to ligation with a ligase to generate a ligated strand that is amenable to lateral flow assessment.

Abstract: A power converter is provided. The power converter includes two or more hybrid switching circuits electrically connected to a source or storage element. Each switching circuit includes a wide bandgap device that is parallel-connected to a silicon-based device. The converter further includes a controller that is operatively coupled to each device of the first and second switching circuits. The controller is configured to operate each hybrid switching circuit by (i) activating the silicon-based device for an activation period, (ii) activating the wide bandgap device for a predetermined duty cycle less than the activation period, (iii) deactivating the silicon-based device while the wide bandgap device is activated, and (iv) deactivating the wide bandgap device. The hybrid switching circuits are sequentially operated to convert an alternating current of a power supply into a link voltage for a power converter, for example.

Abstract: A method and apparatus for assisting in removing a wheels-on-ground type daughter cart from a mother cart, and a mother cart incorporating such a method and apparatus, utilize a daughter cart ejector apparatus mounted on a mother cart and having a selectively actuatable ejector element for urging the daughter cart to move out of engagement with the mother cart in an unloading direction. The ejector element is configured and operatively connected to bear against the daughter cart and apply force in a manner that assists in initiating movement of the daughter cart in the unloading direction and reorienting casters supporting the daughter cart on an underlying surface from a rolling orientation that is generally parallel to a transport direction of the mother cart, to a rolling orientation that is generally transverse to the transport direction and parallel to the unloading direction.

Abstract: Methods, processes and devices are described for measuring a volatile content of a process stream that comprises volatile species, such as light hydrocarbons and/or H2S. The method can include introducing a stripping gas into a sample of the process stream to strip the volatiles therefrom and produce a gas phase comprising vaporized volatiles; detecting the vaporized volatiles in the gas phase to obtain a sample volatile content; and determining the volatile content of the process stream based on the sample volatile content. The method and device can be used to measure a light hydrocarbon content of froth treatment tailings in the context of removing such light hydrocarbons prior to flocculating and dewatering the tailings.

Abstract: The present disclosure describes technologies that permit sensitive detection of nucleic acids of interest (i.e., nucleic acids whose nucleotide sequence is or includes a target sequence).

Abstract: Multi-phase-shift control of a power converter is provided. The power converter includes a dual-active-bridge (DAB) converter having a transformer, a first H-bridge coupled to the primary winding of the transformer, and a second H-bridge coupled to the secondary winding of the transformer. The DAB converter is operable to generate two-level and three-level voltage waveforms on the primary winding and on the secondary winding to yield a system which ensures zero-voltage switching and unity power factor over a wide range of input and output voltage levels and power throughputs. In a multi-phase shift (MPS) mode of operation, the DAB converter changes from a two-level voltage in at least one of the windings to a three-level voltage in both windings in response to the instantaneous load being below a predetermined level, resulting in more efficient performance of the DAB converter in light load conditions.