Patents by Inventor Wayne C. Koff

Wayne C. Koff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREDICTIVE BIOMARKERS FOR AN IMMUNE RESPONSE
    Publication number: 20210325369
    Abstract: Biomarkers and uses thereof, as well as methods for using same for identifying vaccine recipients who will respond to a single dose of vaccine. In addition, an integration model for identifying biomarkers is also provided, such that the biomarkers form a network of signatures associated with a vaccine responder.
    Type: Application
    Filed: July 29, 2019
    Publication date: October 21, 2021
    Inventors: Wayne C. Koff, Richard H. Scheuermann, Tobias Kollmann, Casey P. Shannon, Scott J. Tebbutt
  • Transgenic VERO-CD4/CCR5 cell line
    Patent number: 10894080
    Abstract: The present relation relates to a transgenic Vero cell line expressing CD4 and CCR5. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: January 19, 2021
    Inventors: Christopher L. Parks, Wayne C. Koff
  • TRANSGENIC VERO-CD4/CCR5 CELL LINE
    Publication number: 20190216915
    Abstract: The present relation relates to a transgenic Vero cell line expressing CD4 and CCR5. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Application
    Filed: February 15, 2019
    Publication date: July 18, 2019
    Inventors: Christopher L. Parks, Wayne C. Koff
  • Transgenic Vero-CD4/CCR5 cell line
    Patent number: 10279027
    Abstract: The present relation relates to a transgenic Vero cell line expressing CD4 and CCR5. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: May 7, 2019
    Assignee: INTERNATIONAL AIDS VACCINE INITIATIVE
    Inventors: Christopher L. Parks, Wayne C. Koff
  • Replication-competent VSV-HIV Env vaccines
    Patent number: 9925258
    Abstract: The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: March 27, 2018
    Assignee: INTERNATIONAL AIDS VACCINE INITIATIVE
    Inventors: Christopher L. Parks, Wayne C. Koff
  • TRANSGENIC VERO-CD4/CCR5 CELL LINE
    Publication number: 20170266272
    Abstract: The present relation relates to a transgenic Vero cell line expressing CD4 and CCR5. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Application
    Filed: April 6, 2017
    Publication date: September 21, 2017
    Inventors: Christopher L. Parks, Wayne C. Koff
  • REPLICATION-COMPETENT VSV-HIV ENV VACCINES
    Publication number: 20170095551
    Abstract: The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Application
    Filed: September 29, 2016
    Publication date: April 6, 2017
    Inventors: Christopher L. Parks, Wayne C. Koff
  • HIV-1 envelope glycoprotein
    Patent number: 8586056
    Abstract: The present application relates to a novel HIV-1 envelope glycoprotein which may be utilized as an HIV-1 vaccine immunogen, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: November 19, 2013
    Assignee: International AIDS Vaccine Initiative
    Inventors: Sanjay K. Phogat, Wayne C. Koff, Charles Richter King, Denise Wagner, Simon Hoffenberg
  • ANTIGEN-ANTIBODY COMPLEXES AS HIV-1 VACCINES
    Publication number: 20120258124
    Abstract: The present relation relates to antigen-antibody complexes for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic antibody-antigen complexes which are formulated into the vaccines of the present invention.
    Type: Application
    Filed: January 31, 2012
    Publication date: October 11, 2012
    Inventors: Wayne C. Koff, Sanjay Phogat
  • Method of inducing high-titer neutralizing antibody responses in a host by administering immune complexes comprising anti-HIV-1 Env antibodies and the HIV-1 Env
    Patent number: 8105600
    Abstract: The present relation relates to antigen-antibody complexes for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic antibody-antigen complexes which are formulated into the vaccines of the present invention.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: January 31, 2012
    Assignee: International Aids Vaccine Initiative
    Inventors: Wayne C. Koff, Sanjay Phogat
  • Novel HIV-1 Envelope Glycoprotein
    Publication number: 20110262488
    Abstract: The present application relates to a novel HIV-1 envelope glycoprotein which may be utilized as an HIV-1 vaccine immunogen, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Application
    Filed: March 2, 2011
    Publication date: October 27, 2011
    Inventors: Sanjay K. Phogat, Wayne C. Koff, Charles Richter King, Denise Wagner, Simon Hoffenberg
  • Antigen Antibody Complexes as HIV-1 Vaccines
    Publication number: 20090123485
    Abstract: The present relation relates to antigen-antibody complexes for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic antibody-antigen complexes which are formulated into the vaccines of the present invention.
    Type: Application
    Filed: October 30, 2008
    Publication date: May 14, 2009
    Inventors: Wayne C. Koff, Sanjay Phogat