Patents by Inventor Wayne Childers

Wayne Childers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITION COMPRISING BETA LACTAM FOR TREATING ALCOHOL DEPENDENCE AND ALCOHOL ASSOCIATED DISEASES OR CONDITIONS
    Publication number: 20250057808
    Abstract: A method is provided for treating or preventing alcohol dependence and/or an alcohol associated disease or condition. Such a method includes administrating a pharmaceutical composition comprising an effective amount of a compound having formula (I): or a hydrates, a solvate, a pharmaceutically acceptable salt, a prodrug, or a complex thereof to a subject in need thereof. For example, (3S, 4R)-3-((R)-(1-hydroxy-ethyl)-4-((R)-[1-methyl-2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-azetidin-2-one (MC-100093) is an exemplary compound. The composition can be used to prevent or treat alcohol dependence, attenuate alteration in glutamate transporters, reduce alcohol associated neuroinflammation, and treat or prevent alcohol associated fatty liver diseases.
    Type: Application
    Filed: July 30, 2024
    Publication date: February 20, 2025
    Inventors: Magid Abou-Gharbia, Wayne Childers, Youssef Sari
  • Anti-PCSK9 compounds and methods for the treatment and/or prevention of cardiovascular diseases
    Patent number: 10131637
    Abstract: Disclosed are compounds of the class of 2-phenylacetamides that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), and methods of using these modulators to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (CVD), including treatment of hypercholesterolemia.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: November 20, 2018
    Assignees: Shifa Biomedical Corporation, Temple University—Of The Commonwealth System of Higher Education
    Inventors: Sherin Salaheldin Abdel-Meguid, Magid Abou-Gharbia, Benjamin Blass, Wayne Childers, Nabil Elshourbagy, Victor Ghidu, Rogelio Martinez, Harold Meyers, Shaker A. Mousa
  • Synergistic compositions for treating microbial infections
    Patent number: 10028931
    Abstract: Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the compositions to inhibit a bacterial tRNA synthetase in a cell and to decolonize bacteria on a surface.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: July 24, 2018
    Assignees: University of Rochester, Temple University—Of the Commonwealth System of Higher Education
    Inventors: Paul M. Dunman, Wayne Childers
  • ANTI-PCSK9 COMPOUNDS AND METHODS FOR THE TREATMENT AND/OR PREVENTION OF CARDIOVASCULAR DISEASES
    Publication number: 20180079730
    Abstract: Disclosed are compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), and methods of using these modulators to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (CVD), including treatment of hypercholesterolemia.
    Type: Application
    Filed: December 1, 2017
    Publication date: March 22, 2018
    Inventors: Sherin Salaheldin Abdel-Meguid, Magid Abou-Gharbia, Benjamin Blass, Wayne Childers, Nabil Elshourbagy, Victor Ghidu, Rogelio Martinez, Harold Meyers, Shaker A. Mousa
  • SYNERGISTIC COMPOSITIONS FOR TREATING MICROBIAL INFECTIONS
    Publication number: 20170246139
    Abstract: Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the compositions to inhibit a bacterial tRNA synthetase in a cell and to decolonize bacteria on a surface.
    Type: Application
    Filed: October 30, 2015
    Publication date: August 31, 2017
    Applicants: UNIVERSITY OF ROCHESTER, TEMPLE UNIVERSITY -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Paul M. Dunman, Wayne Childers
  • Small molecule RNase inhibitors and methods of use
    Patent number: 9693999
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: July 4, 2017
    Assignees: University of Rochester, Board of Regents of the University of Nebraska, Temple University—Of the Commonwealth System of Higher Education
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • Small molecule RNase inhibitors and methods of use
    Patent number: 9517230
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: December 13, 2016
    Assignees: UNIVERSITY OF ROCHESTER, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE
    Publication number: 20160115124
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
    Type: Application
    Filed: November 5, 2015
    Publication date: April 28, 2016
    Applicants: UNIVERSITY OF ROCHESTER, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, TEMPLE UNIVERSITY -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • Small molecule RNase inhibitors and methods of use
    Patent number: 9233095
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: January 12, 2016
    Assignees: University of Rochester, Board of Regents of the University of Nebraska, Temple University—Of the Commonwealth System of Higher Education
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • ANTI-PCSK9 COMPOUNDS AND METHODS FOR THE TREATMENT AND/OR PREVENTION OF CARDIOVASCULAR DISEASES
    Publication number: 20150376139
    Abstract: Disclosed are compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), and methods of using these modulators to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (CVD), including treatment of hypercholesterolemia.
    Type: Application
    Filed: March 11, 2014
    Publication date: December 31, 2015
    Inventors: Sherin Salaheldin Abdel-Meguid, Magid Abou-Gharbia, Benjamin Blass, Wayne Childers, Nabil Elshourbagy, Victor Ghidu, Rogelio Martinez, Harold Meyers, Shaker A. Mousa
  • SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE
    Publication number: 20150283118
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.
    Type: Application
    Filed: June 19, 2015
    Publication date: October 8, 2015
    Applicants: UNIVERSITY OF ROCHESTER, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, TEMPLE UNIVERSITY -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • Small molecule RNase inhibitors and methods of use
    Patent number: 9089545
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: July 28, 2015
    Assignees: University of Rochester, Board of Regents of the University of Nebraska, Temple University—Of the Commonwealth System of Higher Education
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE
    Publication number: 20130303585
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
    Type: Application
    Filed: January 26, 2012
    Publication date: November 14, 2013
    Applicants: UNIVERSITY OF ROCHESTER, TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER LEARNING, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE
    Publication number: 20130296386
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.
    Type: Application
    Filed: January 26, 2012
    Publication date: November 7, 2013
    Applicants: UNIVERSITY OF ROCHESTER, TEMPLE UNIVERSITY--OF THE COMMONWEALTH SYSTEM OF HIGHER LEARNING, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • SEROTONERGIC AGENTS FOR TREATING SEXUAL DYSFUNCTION
    Publication number: 20080070925
    Abstract: Methods and compositions are provided for treating sexual dysfunction, e.g., sexual dysfunction associated with drug treatment, using 5-HT1A receptor antagonists.
    Type: Application
    Filed: August 20, 2007
    Publication date: March 20, 2008
    Inventors: Stacey SUKOFF RIZZO, Sharon ROSENZWEIG-LIPSON, Wayne CHILDERS, Michael KELLY, Lee SCHECHTER
  • PYRIMIDOINDOLONES AND METHODS FOR USING SAME
    Publication number: 20070270587
    Abstract: Novel pyrimidoindolone compounds are disclosed. Methods of using the pyrimidoindolone compounds and compositions containing the compounds in the treatment and/or prevention of disease and other conditions related to inflammation, neurodegeneration, osteoarthritis and apoptosis are also disclosed.
    Type: Application
    Filed: July 2, 2007
    Publication date: November 22, 2007
    Applicant: Wyeth
    Inventors: Paul Dollings, Arlene Dietrich, Lisa Havran, Chae-Koo Chong, Donna Huryn, Albert Robichaud, Boyd Harrison, Wayne Childers, Alexander Greenfield, James Bicksler, Vasilios Marathias
  • Bicyclic Indolyl Derivatives and Methods for Their Use as Serotonergic Agents
    Publication number: 20070135445
    Abstract: Bicyclic indolyl derivatives and compositions containing such compounds are disclosed. Methods of using the bicyclic indolyl derivatives and compositions containing such composition as serotonergic agents, such as in the treatment of depression and anxiety, are also disclosed. In addition, processes for the preparation of bicyclic indolyl derivatives are disclosed.
    Type: Application
    Filed: January 15, 2007
    Publication date: June 14, 2007
    Applicant: Wyeth
    Inventors: Micahel Kelly, Wayne Childers, Boyd Harrison, Gan Zhang, Byron Bravo, Lee Schechter
  • Piperazine-piperidine antagonists and agonists of the 5-HT1A receptor
    Publication number: 20070027160
    Abstract: The present invention relates to novel piperazine-piperidine compounds. The compounds are useful as 5-HT1A binding agents, particularly as 5-HT1A receptor antagonists and agonists. These compounds are useful in treating central nervous system disorders, such as cognition disorders, anxiety disorders, depression and sexual dysfunction.
    Type: Application
    Filed: June 9, 2006
    Publication date: February 1, 2007
    Applicant: Wyeth
    Inventors: Magda Asselin, George Grosu, Annmarie Sabb, Wayne Childers, Lisa Havran, Zhongqi Shen, James Bicksler, Dan Chong
  • Serotonergic agents for treating sexual dysfunction
    Publication number: 20060287333
    Abstract: Methods and compositions are provided for treating sexual dysfunction, e.g., sexual dysfunction associated with drug treatment, using 5-HT1A receptor antagonists.
    Type: Application
    Filed: August 18, 2006
    Publication date: December 21, 2006
    Applicant: Wyeth
    Inventors: Stacey Sukoff Rizzo, Sharon Rosenzweig-Lipson, Wayne Childers, Michael Kelly, Lee Schechter
  • Serotonergic agents for treating sexual dysfunction
    Publication number: 20060287335
    Abstract: Methods and compositions are provided for treating sexual dysfunction, e.g., sexual dysfunction associated with drug treatment, using 5-HT1A receptor antagonists.
    Type: Application
    Filed: March 30, 2006
    Publication date: December 21, 2006
    Applicant: Wyeth
    Inventors: Stacey Sukoff Rizzo, Sharon Rosenzweig-Lipson, Wayne Childers, Michael Kelly, Lee Schechter