Patents by Inventor Wayne D Bowen

Wayne D Bowen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aralkyl diazabicycloalkane derivatives for CNS disorders
    Patent number: 6656930
    Abstract: Certain aralkyl diazabicycloalkyl compounds are disclosed for treatment of CNS disorders, such as cerebral ischemia, psychosis, and convulsions.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: December 2, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Wayne D Bowen, Brian R. de Costa, Celia Dominguez, Xiao-Shu He, Kenner C. Rice
  • Potentiation of antineoplastic agents using sigma-2
    Publication number: 20030171397
    Abstract: The present invention relates to the use of sigma-2 agonists to potentiate the activity of antineoplastic agents. These substances are useful for treating cancerous tumors and, in particular, drug resistant tumors in humans. Methods for sensitizing multidrug resistant cells to antitumor agents comprising contacting the cells with a sigma-2 agonist are also described.
    Type: Application
    Filed: May 9, 2003
    Publication date: September 11, 2003
    Inventors: Keith W. Crawford, Wayne D. Bowen
  • Aralkyl diaxabicycloalkane derivatives for CNS disorders
    Publication number: 20020045624
    Abstract: Certain aralkl diazabicycloalkyl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions.
    Type: Application
    Filed: September 4, 2001
    Publication date: April 18, 2002
    Inventors: Wayne D. Bowen, Brian R. De Costa, Celia Dominguez, Xiao-Shu He, Kenner C. Rice
  • Nitrogen-containing cyclohetero cycloalkylaminoaryl derivatives for CNS disorders
    Patent number: 5739158
    Abstract: Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychotic disorders, convulsions and parkinsonism. Compounds of particular interest are of the formula ##STR1## wherein R.sup.1 is selected from hydrido, loweralkyl, cycloalkylalkyl of four to six carbon atoms and loweralkenylloweralkyl; wherein each of R.sup.2 and R.sup.3 is independently selected from hydrido and loweralkyl; wherein each of R.sup.4 through R.sup.7, R.sup.10 and R.sup.
    Type: Grant
    Filed: July 1, 1992
    Date of Patent: April 14, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Brian R. de Costa, Kenner C. Rice, Nancy M. Gray, Patricia C. Contreras, Arthur E. Jacobson, Andrew Thurkauf, Lilian A. Radesca, Wayne D. Bowen, J. Michael Walker
  • Nitrogen-containing cyclohetero alkylamino aryl derivatives for CNS disorders
    Patent number: 5571832
    Abstract: Compounds comprising a pyrrolidinyl ring are disclosed for use in the treatment of cerebral ischemia.
    Type: Grant
    Filed: June 20, 1994
    Date of Patent: November 5, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Brian R. de Costa, Wayne D. Bowen, Xiao-Shu He, Lilian Radesca, Kenner C. Rice
  • Nitrogen-containing cyclohetero cycloalkylaminoaryl derivatives for CNS disorders
    Patent number: 5130330
    Abstract: Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychotic disorders and convulsions. Compounds of particular interest are of the formula ##STR1## wherein R.sup.1 is selected from hydrido, loweralkyl, cycloalkylalkyl of four to six carbon atoms, and loweralkenylloweralkyl; wherein each of R.sup.2 and R.sup.3 is independently selected from hydrido and loweralkyl; wherein each of R.sup.4 through R.sup.7, R.sup.10 and R.sup.
    Type: Grant
    Filed: January 31, 1990
    Date of Patent: July 14, 1992
    Assignee: G. D. Searle & Co.
    Inventors: Brian R. de Costa, Kenner C. Rice, Nancy M. Gray, Patricia C. Contreras, Arthur E. Jacobson, Andrew Thurkauf, Lilian A. Radesca, Wayne D. Bowen