Abstract: Various embodiments provide for the creation and validation of resource templates that may be used to provision or launch resources or resource instances. In various embodiments, a user can use values for various resource instance parameters to create a resource template, and can request validation of that template. A validation service can perform multiple validations, including independent validation of all template parameters, as well as validations of cross-parameter dependencies. If any errors are detected that cause the template to be invalid, information for those errors can be returned to the user such that the user can make the appropriate changes to enable the template to be valid. Templates can be re-validated at future times, such as at launch time or for use with a new service, to ensure the template remains valid under those circumstances.

Abstract: The present invention provides improved methods and compositions based on microvesicles for the treatment of various diseases, disorders and conditions. In particular, the present invention encompasses the recognition that microvesicles contain specific microRNAs which may function as intercellular regulators involved in cell or tissue regeneration, remodeling, reconstruction, reprogramming or transdifferentiation. Thus, among other things, the present invention provides methods and compositions based on microvesicles and/or associated microRNAs that provide more predictable and effective therapeutic results.

Abstract: The present invention provides improved methods and compositions based on microvesicles for the treatment of various diseases, disorders and conditions. In particular, the present invention encompasses the recognition that microvesicles contain specific microRNAs which may function as intercellular regulators involved in cell or tissue regeneration, remodeling, reconstruction, reprogramming or transdifferentiation. Thus, among other things, the present invention provides methods and compositions based on microvesicles and/or associated microRNAs that provide more predictable and effective therapeutic results.

Abstract: The present invention provides improved methods and compositions based on microvesicles for the treatment of various diseases, disorders and conditions. In particular, the present invention encompasses the recognition that microvesicles contain specific microRNAs which may function as intercellular regulators involved in cell or tissue regeneration, remodeling, reconstruction, reprogramming or transdifferentiation. Thus, among other things, the present invention provides methods and compositions based on microvesicles and/or associated microRNAs that provide more predictable and effective therapeutic results.

Abstract: There is disclosed a chair (10) for positioning an individual with respect to a reference location (5), such as a table. The chair (10) comprises a base portion (12) configured to be located on a support surface (6). A seat portion (16) is mounted to the base portion (12) and is configured to receive the individual thereon. A first mechanism (21) is configured to provide rotational movement of said seat portion (16) with respect to said base portion (12). A second mechanism (25) is configured to provide sliding lateral movement of the seat portion (16) with respect to said base portion (12). The first mechanism (21) and the second mechanism (25) are activated independently to facilitate movement of the individual from a first position that is located remote from the reference location (5) to a second position that is located adjacent said reference location (5) without the need for movement of the base portion (12) with respect to the support surface.

Abstract: There is disclosed a chair (10) for positioning an individual with respect to a reference location (5), such as a table. The chair (10) comprises a base portion (12) configured to be located on a support surface (6). A seat portion (16) is mounted to the base portion (12) and is configured to receive the individual thereon. A first mechanism (21) is configured to provide rotational movement of said seat portion (16) with respect Io said base portion (12). A second mechanism (25) is configured to provide sliding lateral movement of the seat portion (16) with respect to said base portion (12). The first mechanism (21) and the second mechanism (25) are activated independently to facilitate movement of the individual from a first position that is located remote from the reference location (5) to a second position that is located adjacent said reference location (5) without the need for movement of the base portion (12) with respect to the support surface.