Patents by Inventor Wayne Fairbrother
Wayne Fairbrother has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12187816Abstract: Provided, inter alia, are macrocyclic compounds.Type: GrantFiled: June 22, 2021Date of Patent: January 7, 2025Assignee: Genentech, Inc.Inventors: Jakob Fuhrmann, Wayne Fairbrother, Hao Wu, Jeremy Murray
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Publication number: 20230330102Abstract: The subject matter described herein is directed to antibody-PROTAC conjugates (PACs), to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where targeted protein degradation is beneficial.Type: ApplicationFiled: May 2, 2023Publication date: October 19, 2023Inventors: Thomas Pillow, Jack Sadowsky, Leanna Staben, Steven Staben, Binqing Wei, Ingrid Wertz, Pragya Adhikari, Nicole Blaquiere, Peter Dragovich, Wayne Fairbrother
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Patent number: 11666581Abstract: The subject matter described herein is directed to antibody-PROTAC conjugates (PACs), to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where targeted protein degradation is beneficial.Type: GrantFiled: November 19, 2018Date of Patent: June 6, 2023Assignee: Genentech, Inc.Inventors: Thomas Pillow, Jack Sadowsky, Leanna Staben, Steven Staben, Binqing Wei, Ingrid Wertz, Pragya Adhikari, Nicole Blaquiere, Peter Dragovich, Wayne Fairbrother
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Publication number: 20220106361Abstract: Provided, inter alia, are macrocyclic compounds.Type: ApplicationFiled: June 22, 2021Publication date: April 7, 2022Applicant: Genentech, Inc.Inventors: Jakob FUHRMANN, Wayne FAIRBROTHER, Hao WU, Jeremy MURRAY
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Publication number: 20190175612Abstract: The subject matter described herein is directed to antibody-PROTAC conjugates (PACs), to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where targeted protein degradation is beneficial.Type: ApplicationFiled: November 19, 2018Publication date: June 13, 2019Inventors: Thomas Pillow, Jack Sadowsky, Leanna Staben, Steven Staben, Binqing Wei, Ingrid Wertz, Pragya Adhikari, Nicole Blaquiere, Peter Dragovich, Wayne Fairbrother
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Publication number: 20120058953Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.Type: ApplicationFiled: October 14, 2011Publication date: March 8, 2012Applicant: Genentech, Inc.Inventors: Kurt Deshayes, Wayne Fairbrother, John Flygare, Matthew C. Franklin, Saloumeh Fischer, Domagoj Vucic
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Publication number: 20110098305Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.Type: ApplicationFiled: May 20, 2009Publication date: April 28, 2011Inventors: Jonathan Bayldon Baell, Guillaume Laurent Lessene, Brad Edmund Sleebs, Wayne Fairbrother, John Flygare, Michael F.T. Koehler
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Publication number: 20110039324Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.Type: ApplicationFiled: July 13, 2010Publication date: February 17, 2011Applicant: Genentech, Inc.Inventors: Kurt Deshayes, Wayne Fairbrother, John Flygare, Matthew C. Franklin, Saloumeh Fischer, Domagoj Vucic
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Publication number: 20090148921Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.Type: ApplicationFiled: September 14, 2006Publication date: June 11, 2009Applicant: Genentech, Inc.Inventors: Kurt Deshayes, Wayne Fairbrother, John Flygare, Matthew C. Franklin, Saloumeh Fischer, Domagoj Vucic
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Publication number: 20080146808Abstract: The invention provides novel inhibitors of IAP that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: X1 and X2 are independently O or S; L is a bond or —C(X3)—, —C(X3)NR12, —C(X3)O— wherein X3 is O or S and R12 is H or R1; R1 is alkyl, a carbocycle, carbocycle-substituted alkyl, a heterocycle or heterocycle-substituted alkyl, wherein each is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, haloalkyl, alkoxy, alkylsulfonyl, amino, nitro, aryl and heteroaryl; R2 is alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, a heterocycle or heterocyclylalkyl; R3 is H or alkyl; R4 and R4? are independently H, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, or heteroaralkyl wherein each is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, alkoxy, amino and nitro; R5, and R5? are each independently H or alkyl; R6 is H or alkyl; and salts and solvates thereof.Type: ApplicationFiled: January 24, 2008Publication date: June 19, 2008Applicant: Genentech, Inc.Inventors: Frederick Cohen, Wayne Fairbrother, John Flygare, Stephen Franz Keteltas, Vickie Hsiao-Wei Tsui
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Patent number: 7345081Abstract: The invention provides novel inhibitors of IAP that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: X1 and X2 are independently O or S; L is a bond or —C(X3)—, —C(X3)NR12, —C(X3)O— wherein X3 is O or S and R12 is H or R1; R1 is alkyl, a carbocycle, carbocycle-substituted alkyl, a heterocycle or heterocycle-substituted alkyl, wherein each is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, haloalkyl, alkoxy, alkylsulfonyl, amino, nitro, aryl and heteroaryl; R2 is alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, a heterocycle or heterocyclylalkyl; R3 is H or alkyl; R4 and R4? are independently H, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, or heteroaralkyl wherein each is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, alkoxy, amino and nitro; R5, and R5? are each independently H or alkyl; R6 is H or alkyl; and salts and solvates thereof.Type: GrantFiled: March 22, 2005Date of Patent: March 18, 2008Assignee: Genentech, Inc.Inventors: Frederick Cohen, Wayne Fairbrother, John Flygare, Stephen Franz Keteltas, Vickie Hsiao-Wei Tsui
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Publication number: 20070299052Abstract: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4?, R5, R5?, R6 and R6? are as described herein.Type: ApplicationFiled: April 23, 2007Publication date: December 27, 2007Applicant: Genentech, Inc.Inventors: Frederick Cohen, Kurt Deshayes, Wayne Fairbrother, Bainian Feng, John Flygare, Lewis Gazzard, Vickie Tsui
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Publication number: 20060276435Abstract: Amino terminus-blocked peptide boronate compounds of Formulas I and II are useful for inhibiting Fibroblast Activation Protein (FAP) and other proteases, and for treating disorders mediated by FAP. Methods of using the amino terminus blocked peptide boronate compounds, and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.Type: ApplicationFiled: May 18, 2006Publication date: December 7, 2006Applicant: Genentech, Inc.Inventors: Frederick Cohen, Wayne Fairbrother, Clifford Quan, Daniel Sutherlin, Beni Wolf
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Publication number: 20060246471Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.Type: ApplicationFiled: December 9, 2005Publication date: November 2, 2006Applicants: Genentech, Inc., The Burnham InstituteInventors: Wayne Fairbrother, Matthew Franklin, Heidi Wallweber, Linda Elliott, Saloumeh Kadkhodayan, Domagoj Vucic, Guy Sallvesen
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Publication number: 20060183194Abstract: The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-?1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These variants include at least one amino acid substitution and can include further modifications. The invention also provides nucleic acid molecules encoding heregulin variants and related vectors, host cells, pharmaceutical compositions, and methods.Type: ApplicationFiled: February 2, 2006Publication date: August 17, 2006Inventors: Marcus Ballinger, Jennifer Jones, Wayne Fairbrother, Mark Sliwkowski, James Wells
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Publication number: 20060014700Abstract: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4?, R5, R5?, R6 and R6? are as described herein.Type: ApplicationFiled: July 5, 2005Publication date: January 19, 2006Applicant: Genentech, Inc.Inventors: Frederick Cohen, Kurt Deshayes, Wayne Fairbrother, Bainian Feng, John Flygare, Lewis Gazzard, Vickie Tsui
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Publication number: 20050261203Abstract: The invention provides novel inhibitors of IAP that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: X1 and X2 are independently O or S; L is a bond or —C(X3)—, —C(X3)NR12, —C(X3)O— wherein X3 is O or S and R12 is H or R1; R1 is alkyl, a carbocycle, carbocycle-substituted alkyl, a heterocycle or heterocycle-substituted alkyl, wherein each is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, haloalkyl, alkoxy, alkylsulfonyl, amino, nitro, aryl and heteroaryl; R2 is alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, a heterocycle or heterocyclylalkyl; R3 is H or alkyl; R4 and R4? are independently H, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, or heteroaralkyl wherein each is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, alkoxy, amino and nitro; R5, and R5 are each independently H or alkyl; R6 is H or alkyl; and salts and solvates thereof.Type: ApplicationFiled: March 22, 2005Publication date: November 24, 2005Applicant: Genentech, Inc.Inventors: Frederick Cohen, Wayne Fairbrother, John Flygare, Stephen Keteltas, Vickie Tsui
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Publication number: 20050214802Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.Type: ApplicationFiled: November 8, 2004Publication date: September 29, 2005Applicants: Genentech, Inc., The Burnham InstituteInventors: Wayne Fairbrother, Matthew Franklin, Heidi Ackerly Wallweber, Linda Elliott, Saloumeh Kadkhodayan, Domagoj Vucic, Guy Salvesen
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Publication number: 20040171554Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.Type: ApplicationFiled: February 7, 2003Publication date: September 2, 2004Applicant: GENENTECH, INC.Inventors: Kurt Deshayes, Wayne Fairbrother, John Flygare, Matthew C. Franklin, Saloumeh Fischer, Domagoj Vucic