Patents by Inventor Wayne H. Knox

Wayne H. Knox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10893936
    Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: January 19, 2021
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra Jani
  • Patent number: 10838233
    Abstract: Described refractive correctors, include, but are not limited to, intraocular lenses (IOLs), contact lenses, corneal inlays, and other optical components or devices, incorporating a continuous central phase zone and peripheral phase discontinuities. Further embodiments are directed to a method for using a laser to modify the refractive properties of refractive correctors to form such continuous central phase zone and peripheral phase discontinuities, and other applications. The refractive corrector and methods adapt a Fresnel lens structure to include continuous phase retarding regions having a wavefront height of greater than one design wavelength in a central zone of a refractive corrector to improve human vision applications, while maintaining benefits of phase wrapping in the peripheral region.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: November 17, 2020
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Gustavo A. Gandara-Montano, Leonard Zheleznyak
  • Patent number: 10813791
    Abstract: A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: October 27, 2020
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Krystel R. Huxlin
  • Patent number: 10806567
    Abstract: A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, which exhibit little or no scattering loss. The method can he used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye. The invention is also directed to an optical device comprising refractive optical structures, which exhibit little or no scattering loss and are characterized by a positive change in refractive index.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: October 20, 2020
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Li Ding, Jay Friedrich Kunzler, Dharmendra M. Jani
  • Patent number: 10649115
    Abstract: A method for modifying the refractive index of an optical polymeric material. The method comprises continuously irradiating predetermined regions of an optical, polymeric material with femtosecond laser pulses to form a gradient index refractive structure within the material. The optical polymeric material can include a photosensitizer to increase the photoefficiency of the two-photo process resulting in the formation of the observed refractive structures. An optical device includes an optical, polymeric lens material having an anterior surface and posterior surface and an optical axis intersecting the surfaces and at least one laser-modified, GRIN layer disposed between the anterior surface and the posterior surface and arranged along a first axis 45° to 90° to the optical axis.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: May 12, 2020
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Dharmendra Jani, Li Ding
  • Publication number: 20200054485
    Abstract: A refractive index writing system includes a pulsed laser source, an objective lens for focusing an output of the pulsed laser source to a focal spot in an optical material, and a scanner for relatively moving the focal spot with respect to the optical material along a scan region. A beam multiplexer divides the output of the laser source into at least two working beams that are focused to variously shaped focal spots within the optical material. A controller controls at least one of a temporal and a spatial offset between the focal spots of the working beams together with the relative speed and direction of the scanner for maintaining an energy profile within the optical material along the scan region above a nonlinear absorption threshold of the optical material and below a breakdown threshold of the optical materials.
    Type: Application
    Filed: March 8, 2018
    Publication date: February 20, 2020
    Inventor: Wayne H. Knox
  • Patent number: 10543076
    Abstract: A laser system for modifying the index of refraction of an optical hydrogel material. The laser system comprises a computer program to determine the position and shape of refractive structures to be written into the optical hydrogel material to correct a patient's vision, and a focused laser that generates laser light having a wavelength of from 400 nm to 900 nm, and which operates with an average power of 10 mW to 1000 mW to produce a pulse energy from 0.05 nJ to 1000 nJ with a peak intensity at focus of greater than 1013 W/cm2. The refractive structures exhibit a change in the index of refraction of 0.01 to 0.06 in the optical hydrogel material.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: January 28, 2020
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra M. Jani
  • Patent number: 10399292
    Abstract: A high numerical aperture opto-mechanical scanner for writing refractive index modifications includes a fast axis scanner having a fast scanning axis. A waveform generator is electrically coupled to the fast axis scanner, and a waveform is provided by the waveform generator which defines a fast scan of the fast axis scanner. A scanning lens assembly is mechanically coupled to the fast axis scanner, the scanning lens assembly having a NA greater than 0.5 and a scanning lens motion along the fast scanning axis. A femtosecond laser is optically coupled through the scanning lens assembly to a surface of a material, creating a femtosecond laser light scanning pattern to write the refractive index modifications into the material. A method for writing refractive index modifications using a high numerical aperture opto-mechanical scanner is also described.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: September 3, 2019
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Jonathan Ellis
  • Publication number: 20190254875
    Abstract: A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 22, 2019
    Inventors: Wayne H. Knox, Krystel R. Huxlin
  • Publication number: 20190240002
    Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.
    Type: Application
    Filed: April 19, 2019
    Publication date: August 8, 2019
    Inventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra Jani
  • Patent number: 10299909
    Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: May 28, 2019
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra Jani
  • Patent number: 10271991
    Abstract: A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: April 30, 2019
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Krystel R. Huxlin
  • Patent number: 10226381
    Abstract: By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: March 12, 2019
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Krystel R. Huxlin, Li Ding
  • Publication number: 20190046357
    Abstract: A laser system for changing the index of refraction of cornea tissue in a living eye. The laser system comprises a laser that provides laser pulses with a wavelength from 400 nm to 900 nm and a pulse energy from 0.01 nJ to 10 nJ, and a control device for setting the operating parameters of the laser below an optical breakdown threshold of the tissue to avoid photo-disruption and tissue destruction of the tissue, and to direct the laser pulses at the cornea tissue resulting in a change in the index of refraction of the tissue within regions irradiated by the laser pulses.
    Type: Application
    Filed: October 17, 2018
    Publication date: February 14, 2019
    Inventors: Wayne H. Knox, Krystel R. Huxlin, Jay F. Kunzler, Li Ding
  • Publication number: 20180373060
    Abstract: Described refractive correctors, include, but are not limited to, intraocular lenses (IOLs), contact lenses, corneal inlays, and other optical components or devices, incorporating a continuous central phase zone and peripheral phase discontinuities. Further embodiments are directed to a method for using a laser to modify the refractive properties of refractive correctors to form such continuous central phase zone and peripheral phase discontinuities, and other applications. The refractive corrector and methods adapt a Fresnel lens structure to include continuous phase retarding regions having a wavefront height of greater than one design wavelength in a central zone of a refractive corrector to improve human vision applications, while maintaining benefits of phase wrapping in the peripheral region.
    Type: Application
    Filed: December 14, 2016
    Publication date: December 27, 2018
    Applicant: University of Rochester
    Inventors: Wayne H. Knox, Gustavo A. Gandara-Montano, Leonard Zheleznyak
  • Publication number: 20180231696
    Abstract: A method for modifying the refractive index of an optical polymeric material. The method comprises continuously irradiating predetermined regions of an optical, polymeric material with femtosecond laser pulses to form a gradient index refractive structure within the material. The optical polymeric material can include a photosensitizer to increase the photoefficiency of the two-photo process resulting in the formation of the observed refractive structures. An optical device includes an optical, polymeric lens material having an anterior surface and posterior surface and an optical axis intersecting the surfaces and at least one laser-modified, GRIN layer disposed between the anterior surface and the posterior surface and arranged along a first axis 45° to 90° to the optical axis.
    Type: Application
    Filed: April 5, 2018
    Publication date: August 16, 2018
    Inventors: Wayne H. Knox, Dharmendra Jani, Li Ding
  • Publication number: 20180206979
    Abstract: A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, which exhibit little or no scattering loss. The method can he used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye. The invention is also directed to an optical device comprising refractive optical structures, which exhibit little or no scattering loss and are characterized by a positive change in refractive index.
    Type: Application
    Filed: March 16, 2018
    Publication date: July 26, 2018
    Inventors: Wayne H. Knox, Li Ding, Jay Friedrich Kunzler, Dharmendra M. Jani
  • Publication number: 20180173009
    Abstract: An optical device for off-axis viewing includes a contact lens adapted for human eye wear. The contact lens includes a diffraction grating written into or on the contact lens. A peripheral light from a peripheral light source is diffracted by the diffraction grating so as to appear at about a same location as light from an ambient scene substantially in a direction of a central field of view. A wearer of the optical device for off-axis viewing sees simultaneously the peripheral light and the light from an ambient scene as superimposed at least in part over each other. A device-less method for correcting light direction from an ambient light source to a retina of a diseased or injured eye, and a remedial contact lens method for correcting light direction from an ambient light source to a retina of a diseased or injured eye are also described.
    Type: Application
    Filed: May 26, 2016
    Publication date: June 21, 2018
    Applicant: University of Rochester
    Inventors: Wayne H. Knox, Leonard A. Zheleznyak
  • Patent number: 9939558
    Abstract: A method for modifying the refractive index of an optical polymeric material. The method comprises continuously irradiating predetermined regions of an optical, polymeric material with femtosecond laser pulses to form a gradient index refractive structure within the material. The optical polymeric material can include a photosensitizer to increase the photoefficiency of the two-photo process resulting in the formation of the observed refractive structures. An optical device includes an optical, polymeric lens material having an anterior surface and posterior surface and an optical axis intersecting the surfaces and at least one laser-modified, GRIN layer disposed between the anterior surface and the posterior surface and arranged along a first axis 45° to 90° to the optical axis.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: April 10, 2018
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Dharmendra Jani, Li Ding
  • Publication number: 20170181846
    Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.
    Type: Application
    Filed: March 10, 2017
    Publication date: June 29, 2017
    Inventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra Jani