Abstract: Methods of using IL-2 fusion proteins to treat and/or prevent transplant rejection such as heart transplant rejection are disclosed.

Abstract: The present disclosure relates to a system, a method, and a product for using deep learning models to quantify and/or improve trust in conversations. The system includes a non-transitory memory storing instructions executable to construct a deep-learning network to quantify trust scores; and a processor in communication with the non-transitory memory. The processor executes the instructions to cause the system to: obtain a trust score for each voice sample in a plurality of audio samples, generate a predicated trust score by the deep-learning network based on each voice sample in the plurality of audio samples, wherein the deep-learning network comprises a plurality of branches and an aggregation network configured to aggregate results from the plurality of branches, and train the deep-learning network based on the predicated trust score and the trust score for each voice sample to obtain a training result.

Abstract: The present disclosure relates to a system, a method, and a product for using machine learning models to quantify and/or improve trust in conversations. The system includes a non-transitory memory; and a processor in communication with the non-transitory memory. The processor executes the instructions to cause the system to: obtain a set of vocal features and a set of text features for each sample in audio samples; obtain a trust score for each sample; perform a preprocess to obtain a set of input features for each sample; determine a type of machine-learning algorithm for the machine-learning network; tune a set of hyper parameters for the machine-learning network; generate a predicated trust score by the machine-learning network with the sets of input features for each sample; and train the machine-learning network based on the predicated trust score and the trust score for each sample to obtain the training result.

Abstract: Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed.

Abstract: The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I?B kinase is involved.

Abstract: The present invention provides methods of suppressing immune disorders such as allograft rejection in a patient by a combination of inhibition of the binding of LIGHT to HVEM and immunosuppressive therapy. Various therapeutic regimens are provided. The present invention further provides kits and pharmaceutical compositions useful in the present methods.

Abstract: A compilier methodology including a stand alone memory interface which provides a user specified memory device of a required number of words of memory of a required bits per word. The stand alone memory interface is a tool to provide a menu showing multiple ways in which the user's request can be physically configured by varying the number of rows of memory, the number of blocks of memory, and the column multiplexing factor of the memory array. From this menu the user selects the memory configuration that best meets the user's requirements and is provided with either various models or representations (views) of the selected memory configuration or a GDS format data file. The views can be used to design large scale integrated circuits in which the memory device is embedded while the data file is used to generate photo mask for making the memory device as an integrated circuit.