Abstract: An actuator has a rotatable input member coupled to a drive member such that rotation of the rotatable input member under an input load causes rotation of the drive member on a first axis. The drive member is coupled to a driven member such that rotation of the drive member causes rotation of the driven member on a second axis which is laterally offset from the first axis. A coupling between the drive member and the driven member is arranged to provide a rotational reduction from the drive member to the driven member. The driven member is arranged for connection to a wire of a Bowden cable having a sleeve seatable in relation to a housing for the actuator such that rotation of the driven member causes extension or retraction of the cable.

Abstract: Methods of treating a cancer or tumor, chemopreventative methods of prophylactically treating cancers or tumors, pharmaceutical compositions, methods for the treatment or prevention of a hypoxia-related pathology, methods of modulating HIF-1 activity in a cell, methods of downregulating HIF-1 activity in a cell, methods of treating or preventing cancer or a tumor in a host, and methods of modulating gene transcription in a cell are described.

Abstract: A nozzle inhibitor is positioned in a filler neck closure assembly between a pivotable outer door and a pivotable inner door to prevent a user from pumping unleaded fuel into a diesel fuel tank. The nozzle inhibitor blocks full insertion of a small-diameter unleaded fuel nozzle into the filler neck closure assembly yet allows full insertion of a large-diameter diesel fuel nozzle into the filler neck closure assembly.

Abstract: An improved hydraulic lash adjuster including a cup-shaped adjuster body, and a plunger assembly disposed within the adjuster body. The plunger assembly includes a stepped axial bore extending from a body inner end to a central oil passage opening onto a hemispherical pivot head. A valve seat for a check valve is disposed against the step, defining a low-pressure oil chamber in the axial bore. A check ball and lash adjustment spring are disposed against the seat in a high-pressure chamber formed between the valve seat and adjuster body. The body of the plunger assembly may be formed by inexpensive processes to a length equivalent to that of a prior art one-piece plunger to resist torsional side loads which may be imposed on the HLA in use. The separately formed valve seat may also be used in other hydraulic lash adjusters such as incorporated in hydraulic valve lifters.

Abstract: A system for bringing an internal combustion engine to a stop at a predetermined angular position of an engine shaft, such as a crankshaft or a camshaft, with respect to the engine's valves. The optimum shaft stop position is the point wherein the fewest lifters are collapsed the least amount. Exemplary methods and apparatus include using the engine starter motor to jog the stopped engine to the desired position; using the engine alternator to impose a variable electromagnetic load on the engine to bring the engine to a stop at the desired position; using variable firing of cylinders to control the deceleration profile to bring the engine to a stop at the desired position; and providing one or more detents formed in the shaft and using a shaft follower to control the stop position of the shaft by engaging the follower into a detent.

Abstract: An improved hydraulic lash adjuster including a cup-shaped adjuster body, and a plunger assembly disposed within the adjuster body. The plunger assembly includes a stepped axial bore extending from a body inner end to a central oil passage opening onto a hemispherical pivot head. A check valve cartridge sub-assembly is disposed against the step, defining a low-pressure oil chamber in the axial bore. A lash adjustment spring is disposed against the cartridge sub-assembly in a high-pressure chamber formed between the sub-assembly and the adjuster body. The cartridge sub-assembly may be used in other hydraulic lash adjusters such as are incorporated in hydraulic valve lifters.

Abstract: Methods of treating cancer or tumor, chemopreventative methods of prophylactically treating cancers or tumors, pharmaceutical compositions, methods for the treatment or prevention of a hypoxia-related pathology, methods of modulating HIF-1 activity in a cell, methods of downregulating HIF-1 activity in a cell, methods of treating or preventing cancer or a tumor in a host, and methods of modulating gene transcription in a cell, are described.

Abstract: An actuator, connectable to and for adjusting a device, comprises a housing having a longitudinal passage extending between first and second ends and defining an opening at or adjacent to the second end, and a spindle supported in the housing and movable longitudinally in the housing passage. The spindle has two oppositely handed, longitudinally spaced threaded first and second portions respectively nearer to the first and second ends of the housing. A first threaded nut fixed relative to the housing is threadedly engaged with the first threaded portion. A handle rotatably mounted at the first end of the housing is coupled to the spindle for rotating the spindle in the first nut and thereby moving the spindle longitudinally relative to the first nut and the housing.

Abstract: A modular automotive audio system includes a controller housing and an amplifier housing to be mounted within the vehicle trunk and a remote control for use within the passenger compartment. Modular signal processing components are received within the controller housing, and modular amplifier components are received within the amplifier housing. A controller module within the controller housing provides control for all signal processing components. The controller module polls all positions within the controller housing to determine which components are installed, and then the controller module configures itself via software to provide the control functions. Optionally, non-audio electronic components can also be received within the controller housing for common control by the system.

Abstract: A modular automotive audio system includes a controller housing and an amplifier housing to be mounted within the vehicle trunk and a remote control for use within the passenger compartment. Modular signal processing components are received within the controller housing, and modular amplifier components are received within the amplifier housing. A controller module within the controller housing provides control for all signal processing components. The controller module polls all positions within the controller housing to determine which components are installed, and then the controller module configures itself via software to provide the control functions. Optionally, non-audio electronic components can also be received within the controller housing for common control by the system.

Abstract: A ribbon cable carrying ground and signal wires in a single plane includes, at predetermined intervals, separator materials inserted between the signal wires and the ground wires to facilitate separation upon termination. A method for manufacturing such a cable includes the steps of separately guiding the signal and ground wires to a lamination station, and means for inserting the separator material between the signal and ground wires at predetermined intervals prior to lamination.