Patents by Inventor Wayne I. Lencer

Wayne I. Lencer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Central airway administration for systemic delivery of therapeutics
    Publication number: 20040063912
    Abstract: The present invention relates to methods and products for the transepithelial systemic delivery of therapeutics. In particular, the invention relates to methods and compositions for the systemic delivery of therapeutics by administering an aerosol containing antibodies or conjugates of a therapeutic agent with an FcRn binding partner to epithelium of central airways of the lung. The methods and products are adaptable to a wide range of therapeutic agents, including proteins and polypeptides, nucleic acids, drugs, and others. In particular embodiments the conjugates are fusion proteins in which a therapeutic polypeptide is joined at its C terminal end through a peptide linker to the N terminal end of an immunoglobulin Fc gamma heavy chain, wherein the linker includes Glycine and Serine residues and is preferably 15 amino acids long.
    Type: Application
    Filed: July 17, 2003
    Publication date: April 1, 2004
    Applicants: The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation, Brandeis University, Syntonix Pharmaceuticals, Inc.
    Inventors: Richard S. Blumberg, Wayne I. Lencer, Neil E. Simister, Alan J. Bitonti
  • Central airway administration for systemic delivery of therapeutics
    Publication number: 20030235536
    Abstract: The present invention relates to methods and products for the transepithelial systemic delivery of therapeutics. In particular, the invention relates to methods and compositions for the systemic delivery of therapeutics by administering an aerosol containing antibodies or conjugates of a therapeutic agent with an FcRn binding partner to epithelium of central airways of the lung. The methods and products are adaptable to a wide range of therapeutic agents, including proteins and polypeptides, nucleic acids, drugs, and others. The methods and products have the advantage of not requiring administration to the deep lung in order to effect systemic delivery.
    Type: Application
    Filed: May 9, 2003
    Publication date: December 25, 2003
    Applicants: The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation, Brandeis University, Syntonix Pharmaceuticals, Inc.
    Inventors: Richard S. Blumberg, Wayne I. Lencer, Neil E. Simister, Alan J. Bitonti
  • Method for reducing chloride secretion by intestinal epithelial cells in situ: use of triaryl methane compounds
    Publication number: 20030119784
    Abstract: A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.
    Type: Application
    Filed: November 8, 2002
    Publication date: June 26, 2003
    Inventors: Wayne I. Lencer, Carlo Brugnara, Seth Alper
  • Receptor specific transepithelial transport of therapeutics
    Publication number: 20030012789
    Abstract: The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
    Type: Application
    Filed: August 8, 2002
    Publication date: January 16, 2003
    Inventors: Richard S. Blumberg, Neil E. Simister, Wayne I. Lencer
  • Receptor specific transepithelial transport of therapeutics
    Publication number: 20020192222
    Abstract: The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
    Type: Application
    Filed: August 8, 2002
    Publication date: December 19, 2002
    Inventors: Richard S. Blumberg, Neil E. Simister, Wayne I. Lencer
  • Triaryl methane compounds and their use in the treatment of diarrhea and scours
    Patent number: 6495567
    Abstract: A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.
    Type: Grant
    Filed: September 23, 1998
    Date of Patent: December 17, 2002
    Assignees: Beth Israel Deaconess Medical Center, Children's Medical Center Corporation
    Inventors: Wayne I. Lencer, Carlo Brugnara, Seth Alper
  • Receptor specific transepithelial transport of therapeutics
    Patent number: 6485726
    Abstract: The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: November 26, 2002
    Assignees: The Brigham and Women's Hospital, Inc., Brandeis University
    Inventors: Richard S. Blumberg, Neil E. Simister, Wayne I. Lencer
  • METHOD FOR REDUCING CHLORIDE SECETION BY INTESTINAL EPITHLIAL CELLS IN SITU
    Publication number: 20020004519
    Abstract: A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.
    Type: Application
    Filed: September 23, 1998
    Publication date: January 10, 2002
    Inventors: WAYNE I. LENCER, CARLO BRUGNARA, SETH ALPER
  • Use of 11-phenyl-dibenzazepine compounds to treat diarrhea or scours
    Patent number: 6291449
    Abstract: A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.
    Type: Grant
    Filed: September 23, 1998
    Date of Patent: September 18, 2001
    Assignees: Children's Medical Center Corporation, Beth Israel Deaconess Medical Center
    Inventors: Wayne I. Lencer, Carlo Brugnara, Seth Alper
  • Receptor specific transepithelial transport of therapeutics
    Patent number: 6030613
    Abstract: The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
    Type: Grant
    Filed: July 24, 1997
    Date of Patent: February 29, 2000
    Assignees: The Brigham and Women's Hospital, Inc., Brandeis University
    Inventors: Richard S. Blumberg, Neil E. Simister, Wayne I. Lencer
  • Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds
    Patent number: 5889038
    Abstract: A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: March 30, 1999
    Assignee: Children's Hospital
    Inventors: Wayne I. Lencer, Carlo Brugnara, Seth Alper