Patents by Inventor Wayne Kelln

Wayne Kelln has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IRON REGULATING PROTEIN-2 (IRP-2) AS A DIAGNOSTIC FOR NEURODEGENERATIVE DISEASE
    Publication number: 20080020393
    Abstract: The present invention relates to the discovery of markers for neurodegenerative disease. More particularly, it was discovered that forms of IRP-2 protein that are unable to undergo oxidation at critical cysteine residues are diagnostic for neurodegenerative disease including, but not limited to Alzheimer's disease. Embodiments include nucleic acids that encode mutant IRP-2 proteins and fragments thereof, mutant IRP-2 proteins and fragments thereof, antibodies directed to epitopes present on mutant IRP-2 proteins and fragments thereof, methods of making these nucleic acids and polypeptides, as well as, approaches to diagnose neurodegenerative disease in animals, such as humans at risk of contracting Alzheimer's disease.
    Type: Application
    Filed: June 27, 2007
    Publication date: January 24, 2008
    Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER
    Inventors: Wolff Kirsch, Anton Lennart, Wayne Kelln, Dae-Kyung Kang, Rodney Levine, Tracey Rouault
  • Method of detecting colon cancer
    Patent number: 7252955
    Abstract: An immunological assay and kit for colon cancer screening is disclosed. Fecal glycoproteins are extracted from individual samples such that immunogenicity is maintained. The purified fecal glycoproteins are reacted with antibodies to Colon and Ovarian Tumor Antigen (COTA). The mucin antigen COTA is specifically present in colorectal cancer tissue and not in normal colons. The amount of COTA in the fecal sample is determined and used to indicate the presence of colon cancer.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: August 7, 2007
    Assignee: Loma Linda University Adventist Health Sciences Center
    Inventors: Keshab D. Pant, John D. McCracken, Omar Fagoaga, Wayne Kelln, Sandra Nehlsen-Cannarella
  • Antibodies to iron regulating protein -2 (IRP-2) as a diagnostic for neurodegenerative disease
    Publication number: 20050260669
    Abstract: The present invention relates to the discovery of markers for neurodegenerative disease. More particularly, it was discovered that forms of IRP-2 protein that are unable to undergo oxidation at critical cysteine residues are diagnostic for neurodegenerative disease including, but not limited to Alzheimer's disease. Embodiments include nucleic acids that encode mutant IRP-2 proteins and fragments thereof, mutant IRP-2 proteins and fragments thereof, antibodies directed to epitopes present on mutant IRP-2 proteins and fragments thereof, methods of making these nucleic acids and polypeptides, as well as, approaches to diagnose neurodegenerative disease in animals, such as humans at risk of contracting Alzheimer's disease.
    Type: Application
    Filed: July 1, 2005
    Publication date: November 24, 2005
    Inventors: Wolff Kirsch, Anton Lennart, Wayne Kelln, Dae-Kyung Kang, Rodney Levine, Tracey Rouault
  • Method of detecting colon cancer
    Publication number: 20040110234
    Abstract: An immunological assay and kit for colon cancer screening is disclosed. Fecal glycoproteins are extracted from individual samples such that immunogenicity is maintained. The purified fecal glycoproteins are reacted with antibodies to Colon and Ovarian Tumor Antigen (COTA). The mucin antigen COTA is specifically present in colorectal cancer tissue and not in normal colons. The amount of COTA in the fecal sample is determined and used to indicate the presence of colon cancer.
    Type: Application
    Filed: November 25, 2003
    Publication date: June 10, 2004
    Inventors: Keshab D. Pant, John D. McCracken, Omar Fagoaga, Wayne Kelln, Sandra Nehlsen-Cannarella
  • Method of detecting colon cancer
    Patent number: 6703206
    Abstract: An immunological assay and kit for colon cancer screening is disclosed. Fecal glycoproteins are extracted from individual samples such that immunogenicity is maintained. The purified fecal glycoproteins are reacted with antibodies to Colon and Ovarian Tumor Antigen (COTA). The mucin antigen COTA is specifically present in colorectal cancer tissue and not in normal colons. The amount of COTA in the fecal sample is determined and used to indicate the presence of colon cancer.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: March 9, 2004
    Assignee: Loma Linda University Adventist Health Sciences Center
    Inventors: Keshab D. Pant, John D. McCracken, Omar Fagoaga, Wayne Kelln, Sandra Nehlsen-Cannarella
  • Method of detecting colon cancer
    Patent number: 6531319
    Abstract: An immunological assay and kit for colon cancer screening is disclosed. Fecal glycoproteins are extracted from individual samples such that immunogenicity is maintained. The purified fecal glycoproteins are reacted with antibodies to Colon and Ovarian Tumor Antigen (COTA). The mucin antigen COTA is specifically present in colorectal cancer tissue and not in normal colons. The amount of COTA in the fecal sample is determined and used to indicate the presence of colon cancer.
    Type: Grant
    Filed: May 10, 2000
    Date of Patent: March 11, 2003
    Inventors: Keshab D. Pant, John D. McCracken, Omar Fagoaga, Wayne Kelln, Sandra Nehlsen-Cannarella
  • Method of detecting colon cancer
    Publication number: 20020009760
    Abstract: An immunological assay and kit for colon cancer screening is disclosed. Fecal glycoproteins are extracted from individual samples such that immunogenicity is maintained. The purified fecal glycoproteins are reacted with antibodies to Colon and Ovarian Tumor Antigen (COTA). The mucin antigen COTA is specifically present in colorectal cancer tissue and not in normal colons. The amount of COTA in the fecal sample is determined and used to indicate the presence of colon cancer.
    Type: Application
    Filed: July 25, 2001
    Publication date: January 24, 2002
    Inventors: Keshab D. Pant, John D. McCracken, Omar Fagoaga, Wayne Kelln, Sandra Nehlsen-Cannarella