Patents by Inventor Wayne Kindsvogel

Wayne Kindsvogel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

METHODS FOR TREATING VIRAL INFECTION USING IL-28 AND IL-29 CYSTEINE MUTANTS

Publication number: 20080075693

Abstract: IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

Type: Application

Filed: September 20, 2007

Publication date: March 27, 2008

Inventors: Kevin Klucher, Wayne Kindsvogel, Pallavur Sivakumar, Katherine Henderson
ANTI-IL-TIF ANTIBODIES AND METHODS OF USING IN INFLAMMATION

Publication number: 20080033148

Abstract: The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.

Type: Application

Filed: July 27, 2007

Publication date: February 7, 2008

Inventors: Wenfeng Xu, Wayne Kindsvogel, Steven Hughes, Yasmin Chandrasekher
HUMAN CYTOKINE RECEPTOR

Publication number: 20070299247

Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.

Type: Application

Filed: July 26, 2007

Publication date: December 27, 2007

Inventors: Scott Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen, Steven Hughes
METHODS FOR TREATING VIRAL INFECTION USING IL-28 AND IL-29

Publication number: 20070264228

Abstract: IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

Type: Application

Filed: October 11, 2006

Publication date: November 15, 2007

Inventors: Kevin Klucher, Pallavur Sivakumar, Wayne Kindsvogel, Katherine Henderson
POLYNUCLEOTIDES ENCODING CYTOKINE RECEPTOR

Publication number: 20070264685

Abstract: Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Type: Application

Filed: October 9, 2006

Publication date: November 15, 2007

Inventors: SCOTT PRESNELL, Wenfeng Xu, Julia Novak, Theodore Whitmore, Francis Grant, Wayne Kindsvogel, Kevin Klucher
CYTOKINE PROTEIN FAMILY

Publication number: 20070264684

Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.

Type: Application

Filed: October 5, 2006

Publication date: November 15, 2007

Inventors: Paul Sheppard, Brian Fox, Kevin Klucher, David Taft, Wayne Kindsvogel
CYTOKINE PROTEIN FAMILY

Publication number: 20070254340

Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.

Type: Application

Filed: October 5, 2006

Publication date: November 1, 2007

Inventors: Paul Sheppard, Brian Fox, Kevin Klucher, David Taft, Wayne Kindsvogel
Anti-IL-TIF antibodies and methods of making

Patent number: 7265211

Abstract: The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.

Type: Grant

Filed: March 24, 2003

Date of Patent: September 4, 2007

Assignee: ZymoGenetics, Inc.

Inventors: Wenfeng Xu, Wayne Kindsvogel, Steven D. Hughes, Yasmin A. Chandrasekher
Human cytokine receptor

Patent number: 7265203

Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.

Type: Grant

Filed: October 19, 2004

Date of Patent: September 4, 2007

Assignee: ZymoGenetics, Inc.

Inventors: Scott R. Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen, Steven D. Hughes
METHODS OF TREATING CANCER USING IL-21 AND MONOCLONAL ANTIBODY THERAPY

Publication number: 20070178063

Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

Type: Application

Filed: October 6, 2006

Publication date: August 2, 2007

Inventors: Wayne Kindsvogel, Steven Hughes, Richard Holly, Christopher Clegg, Donald Foster, Rebecca Johnson, Mark Heipel, Pallavur Sivakumar
METHODS FOR TREATING VIRAL INFECTION USING IL-28 AND IL-29

Publication number: 20070173445

Abstract: IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

Type: Application

Filed: October 11, 2006

Publication date: July 26, 2007

Inventors: Kevin Klucher, Pallavur Sivakumar, Wayne Kindsvogel, Katherine Henderson
METHODS FOR TREATING VIRAL INFECTION USING IL-28 AND IL-29

Publication number: 20070172451

Abstract: IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

Type: Application

Filed: October 11, 2006

Publication date: July 26, 2007

Inventors: Kevin Klucher, Pallavur Sivakumar, Wayne Kindsvogel, Katherine Henderson
METHODS FOR TREATING VIRAL INFECTION USING IL-28 AND IL-29

Publication number: 20070172452

Abstract: IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

Type: Application

Filed: October 11, 2006

Publication date: July 26, 2007

Inventors: Kevin Klucher, Pallavur Sivakumar, Wayne Kindsvogel, Katherine Henderson
HUMAN CYTOKINE RECEPTOR

Publication number: 20070166746

Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.

Type: Application

Filed: February 1, 2007

Publication date: July 19, 2007

Inventors: Scott Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen
HUMAN CYTOKINE RECEPTOR

Publication number: 20070148143

Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.

Type: Application

Filed: February 1, 2007

Publication date: June 28, 2007

Inventors: Scott Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen
CYTOKINE PROTEIN FAMILY

Publication number: 20070141676

Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.

Type: Application

Filed: October 5, 2006

Publication date: June 21, 2007

Inventors: Paul Sheppard, Brian Fox, Kevin Klucher, David Taft, Wayne Kindsvogel
HUMAN CYTOKINE RECEPTOR

Publication number: 20070135347

Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.

Type: Application

Filed: February 1, 2007

Publication date: June 14, 2007

Inventors: Scott Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen
HUMAN CYTOKINE RECEPTOR

Publication number: 20070134237

Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.

Type: Application

Filed: February 1, 2007

Publication date: June 14, 2007

Inventors: Scott Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen
ANTIBODIES TO CYTOKINE RECEPTOR

Publication number: 20070134727

Abstract: Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Type: Application

Filed: October 9, 2006

Publication date: June 14, 2007

Inventors: SCOTT PRESNELL, Wenfeng Xu, Julia Novak, Theodore Whitmore, Francis Grant, Wayne Kindsvogel, Kevin Klucher
HUMAN CYTOKINE RECEPTOR

Publication number: 20070134745

Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.

Type: Application

Filed: February 1, 2007

Publication date: June 14, 2007

Inventors: Scott Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen

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