Patents by Inventor Wayne Minobe

Wayne Minobe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis and treatment of myocardial failure
    Patent number: 7482331
    Abstract: The invention provides a method of treating myocardial failure in a human. The method comprises administering an effective amount of transgene encoding ?-MHC that directly causes an increase in the quantity of ?-MHC in the myocardial tissue of the heart.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: January 27, 2009
    Assignee: The Regents of the University of Colorado
    Inventors: Michael R. Bristow, Leslie A. Leinwand, Wayne Minobe, Koichi Nakao
  • Diagnosis and treatment of myocardial failure
    Patent number: 7049066
    Abstract: The present invention provides methods of diagnosing myocardial failure in a human. The methods comprise obtaining a sample of myocardial tissue from a ventricle of the heart. In one embodiment, the expression of ?-myosin heavy chain, ?-myosin heavy chain, or both, are quantitated and their expression levels compared to that seen normal human ventricular myocardial tissues. In another embodiment, the expression of ?1-thyroid hormone receptor, ?2-thyroid hormone receptor, a ?1-thyroid hormone receptor+?1-thyroid hormone receptor, or combinations thereof, are quantitated, and their expression levels compared to that seen normal human ventricular myocardial tissues. Therapeutic interventions based on altering the expression of the aforementioned genes also are provide.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: May 23, 2006
    Assignee: The Regents of the University of Colorado
    Inventors: Michael R. Bristow, Leslie A. Leinwand, Wayne Minobe, Koichi Nakao, Koichiro Kinugawa
  • Diagnosis and treatment of myocardial failure
    Publication number: 20050214835
    Abstract: The invention provides methods of diagnosing myocardial failure in a human. The methods comprise obtaining a sample of myocardial tissue from a ventricle of the heart of the human. In one method, the expression of ?-myosin heavy chain (?-MHC), ?-myosin heavy chain (?-MHC), or both in the sample is quantitated, and it is determined by statistical analysis if the expression of ?-MHC, ?-MHC, or both in the sample is significantly different than their expression in normal human ventricular myocardial tissue. A second method comprises quantitating the expression of ?1-thyroid hormone receptor (?1-THR), ?2-THR, ?1-THR+?1-THR, or combinations thereof in the sample, and determining by statistical analysis if the expression of ?1-THR, ?2-THR, or ?1-THR+?1-THR in the sample is significantly different than their expression in normal human ventricular myocardial tissue. The invention also provides kits for diagnosing myocardial failure by these methods.
    Type: Application
    Filed: February 25, 2005
    Publication date: September 29, 2005
    Inventors: Michael Bristow, Leslie Leinwand, Wayne Minobe, Koichi Nakao, Koichiro Kinugawa
  • Diagnosis and treatment of myocardial failure
    Publication number: 20030134282
    Abstract: The invention provides methods of diagnosing myocardial failure in a human. The methods comprise obtaining a sample of myocardial tissue from a ventricle of the heart of the human. In one method, the expression of &agr;-myosin heavy chain ((&agr;-MHC), &bgr;-myosin heavy chain (&bgr;-MHC), or both in the sample is quantitated, and it is determined by statistical analysis if the expression of &agr;-MHC, &bgr;-MHC, or both in the sample is significantly different than their expression in normal human ventricular myocardial tissue. A second method comprises quantitating the expression of &agr;1-thyroid hormone receptor (&agr;1-THR), &agr;2-THR, &agr;1-THR+&bgr;1-THR, or combinations thereof in the sample, and determining by statistical analysis if the expression of &agr;1-THR, &agr;2-THR, or &agr;1-THR+&bgr;1-THR in the sample is significantly different than their expression in normal human ventricular myocardial tissue.
    Type: Application
    Filed: October 1, 2001
    Publication date: July 17, 2003
    Applicant: University Technology Corporation
    Inventors: Michael R. Bristow, Leslie A. Leinwand, Wayne Minobe, Koichi Nakao, Koichiro Kinugawa