Abstract: Vascular access assemblies for facilitating hemodialysis of a patient. The vascular access assembly may include a first tubular conduit and a bifurcated stent disposed in the superior vena cava. The vascular access assembly may further include a second tubular conduit that connects that couples an arm of the bifurcated stent to the first tubular conduit to create a blood flow pathway between two locations of a vasculature of a patient.

Abstract: Medical devices including vascular access kits and related methods are disclosed. In some embodiments, a vascular access system may include a first conduit, a second conduit, and a connector that is reversibly or irreversibly coupled to both the first and second conduits such that there is a continuous lumen from the first conduit and the second conduit. In some embodiments the vascular access system may include a connector where the inside geometry of the connector enhances laminar flow. The vascular access system, when implanted and assembled, may be a fully subcutaneous surgical implant.

Abstract: Implantable devices—such as stents and rings—that comprise markers for tracking their deployment in a body lumen are disclosed. The markers may be used to monitor progress of expansion of the implantable device, potential migration of the implantable device, and diameters of the body lumen. Markers may be deployed in the body lumen separately from another implantable device to assist tracking of migration of the implantable device. Markers may be placed circumferentially around a wall of a body lumen to track growth of an aneurysm or a stricture.

Abstract: A vascular stent deployment device and related methods are disclosed. In some embodiments the deployment device may include a delivery catheter assembly. The delivery catheter assembly may include a self-expanding stent constrained by a rupturable sleeve. The self-expanding stent is disposed around an expandable member configured to partially expand to rupture the sleeve allowing the self-expanding stent to deploy. The expandable member may also be configured to aid in proximal displacement of the self-expanding stent as the delivery catheter assembly is manipulated to deploy the self-expanding stent.

Abstract: Medical appliances, such as stent grafts, may be formed of a cover and a scaffolding. The cover is composed of multiple layers of polymeric materials. A luminal layer is formed of rotational spun fibers of polytetrafluoroethylene. An abluminal layer is formed of expanded polytetrafluoroethylene. The scaffolding is disposed between the luminal layer and the abluminal layer. A cell impermeable layer is also disposed between the luminal layer and the abluminal layer. The cell impermeable layer is formed of an elastomeric material. The cell impermeable layer is impervious to cell migration across the layer when the stent graft is in a nominal state and in an expanded state. The stent graft is free of pleats or wrinkles when the stent graft is in the nominal state and in the expanded state.

Abstract: Bifurcated endovascular prostheses used to treat diseased blood vessels, such as arteries, are disclosed. In some embodiments, the bifurcated endovascular prosthesis is configured to be implanted within the diseased blood vessels adjacent a diseased section. The bifurcated endovascular prosthesis includes a primary stent graft and a secondary stent graft. The primary stent graft includes a pocket or sleeve disposed within a bore. A proximal portion of the secondary stent graft is disposed within the pocket or sleeve. Blood flow through the bifurcated endovascular prosthesis is divided into two flows, a first flow through the primary stent graft and a second flow through the secondary stent graft.

Abstract: Bifurcated endovascular prostheses used to treat diseased blood vessels, such as arteries, are disclosed. In some embodiments, the bifurcated endovascular prosthesis is configured to be implanted within the diseased blood vessels adjacent a diseased section. The bifurcated endovascular prosthesis includes a primary stent graft and a secondary stent graft. The primary stent graft includes a pocket or sleeve disposed within a bore. A proximal portion of the secondary stent graft is disposed within the pocket or sleeve. Blood flow through the bifurcated endovascular prosthesis is divided into two flows, a first flow through the primary stent graft and a second flow through the secondary stent graft.

Abstract: A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis.

Abstract: A medical appliance or prosthesis comprising a support structure and a covering is disclosed. The support structure includes a frame comprising a wire winding. The wire winding includes an end row including apexes and troughs. The apexes and troughs are configured to allow crimping of the frame to a low profile while reducing strain on the wire. The covering includes a multilayer construct including fibrous inner and outer layers and a barrier layer.

Abstract: Devices used to restrict flow within a blood vessel are disclosed. Devices within the scope of this disclosure include a braided lattice of nitinol wires that form self-expanding enclosures of an embolic structure. The devices may further include embolic particles disposed within the enclosures. Methods of deploying the devices with the embolic particles are disclosed. Methods of manufacturing the devices with the embolic particles disposed within the enclosures are disclosed.

Abstract: A vascular prosthesis deployment device and related methods are disclosed. In some embodiments the deployment device may include a delivery catheter assembly. The delivery catheter assembly may include a pliant member, wherein the pliant member is configured receive a vascular prosthesis. The pliant member may also be configured to aid in incrementally deploying a vascular prosthesis. The pliant member may also be configured to aid in adjusting a length of the vascular prosthesis during deployment.

Abstract: Sheets of material used in medical devices and filters are disclosed. The sheets may include a fibrous mat including a plurality of microfibers. The microfibers may include a polymer matrix and a plurality of additive particles. The additive particles may include carbon material particles, therapeutic micro particles, and any combination thereof. Medical devices and filters that use the sheets are disclosed. Methods of producing the sheets are also disclosed.

Abstract: The present disclosure relates to a medical anchor device and methods of use for providing an improved device for intraluminally directed vascular anastomosis. The anchor device includes a generally tubular graft having a flange disposed at one end thereof, where a portion of the graft extends through the flange. The flange includes a wire frame made of a resilient material and a thin membrane covering or overlaying the wire frame, where the wire frame is self-expanding when deployed within a lumen. The device may be deployed within the lumen at an anastomotic site without a need for sutures, staples, clips, or other mechanical attachment means that may cause further injury.

Abstract: A vascular prosthesis deployment device and related methods are disclosed. In some embodiments the deployment device may include a delivery catheter assembly. The delivery catheter assembly may include a pliant member, wherein the pliant member is configured receive a vascular prosthesis. The pliant member may also be configured to aid in incrementally deploying a vascular prosthesis.

Abstract: A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis.

Abstract: Systems and methods of implanting a vascular access technologies and declotting vascular access technologies, such as vascular access assemblies that facilitate hemodialysis, are provided. The methods can include disposing a first tubular conduit within a patient to access a vascular access assembly within the heart of the patient. The first tubular conduit can be coupled to the vascular access assembly such that the first tubular conduit can be decoupled from the vascular access assembly to evacuate a clot within the vascular access assembly, and then recouple the first tubular conduit to the vascular access assembly.

Abstract: Medical appliances may be formed of multilayered constructs. The layers of the constructs may be configured with various physical properties or characteristics. The disposition and arrangement of each layer may be configured to create an overall construct with a combination of the individual properties of the layers. Constructs may be used to create vascular prostheses or other medical devices.

Abstract: Devices used to provide vascular access, methods of manufacture, and methods of use are disclosed. The devices may be a vascular graft having a wall configured to seal following repeated punctures with a needle. The wall may include a plurality of layers of differing materials. The wall may also include a bead configured to prevent kinking of the vascular graft. The bead may be spirally wrapped around the vascular graft or be discrete C-shaped beads that provide a gap for needle access.

Abstract: Medical appliances may be formed of multilayered constructs. The layers of the constructs may be configured with various physical properties or characteristics. The disposition and arrangement of each layer may be configured to create an overall construct with a combination of the individual properties of the layers. Constructs may be used to create vascular prostheses or other medical devices.

Abstract: Vascular access devices, assemblies, kits, and related methods are disclosed. A vascular access assembly may include a first tubular conduit, a second tubular conduit, and an expandable stent graft that is coupled adjacent to a peripheral end of the second tubular conduit. When implanted into the patient, vascular access assemblies may form a flow path that extends from an artery or an arteriovenous graft to a heart of a patient. The vascular access assembly, when implanted and assembled, may be a fully subcutaneous surgical implant.