Abstract: In one example, an integrated circuit comprises: a memory configured to store a first mapping between a first opcode and first control information and a second mapping between the first opcode and second control information; a processing engine configured to perform processing operations based on the control information; and a controller configured to: at a first time, provide the first opcode to the memory to, based on the first mapping stored in the memory, fetch the first control information for the processing engine, to enable the processing engine to perform a first processing operation based on the first control information; and at a second time, provide the first opcode to the memory to, based on the second mapping stored in the memory, fetch the second control information for the processing engine, to enable the processing engine to perform a second processing operation based on the second control information.

Abstract: Methods and systems for performing hardware approximation of function are provided. In one example, a system comprises a controller, configurable arithmetic circuits, and a mapping table. The mapping table stores a first set of function parameters in a first mode of operation and stores a second set of function parameters in a second mode of operation. Depending on the mode of operation, the controller may configure the arithmetic circuits to compute a first approximation result of a function at an input value based on the first set of function parameters, or to compute a second approximation result of the function at the input value based on the second set of function parameters and to perform post-processing, such as quantization, of the second approximation result.

Abstract: Methods and systems for performing hardware computations of mathematical functions are provided. In one example, a system comprises a mapping table that maps each base value of a plurality of base values to parameters related to a mathematical function; a selection module configured to select, based on an input value, a first base value and first parameters mapped to the first base value in the mapping table; and arithmetic circuits configured to: receive, from the mapping table, the first base value and the first plurality of parameters; and compute, based on a relationship between the input value and the first base value, and based on the first parameters, an estimated output value of the mathematical function for the input value.

Abstract: The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides. Compositions include nucleic acid compositions and protein compositions with affinity binding pairs, including metal binding peptides and immobilized metals, or peptide affinity groups.

Abstract: The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides. Compositions include nucleic acid compositions and protein compositions with affinity binding pairs, including metal binding peptides and immobilized metals, or peptide affinity groups.

Abstract: The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides. Compositions include nucleic acid compositions and protein compositions with affinity binding pairs, including metal binding peptides and immobilized metals, or peptide affinity groups.

Abstract: A reconfigurable processing circuit and system are provided. The system allows a user to program machine-level instructions in order to reconfigure the way the circuit behaves, including by adding new operations. The system can include a profile access content-addressable memory (CAM) configured to receive an execution step value from a step counter. The execution step value can be incremented and/or reset by a step management logic. The profile access CAM can select an entry of a profile table based on an opcode and the execution step value, and the processing engine can execute microcode based on the selected entry of the profile table. The profile access CAM can translate the opcode to an internal short instruction identifier in order to select the entry of the profile table. The system can further include an instruction decoding module configured to merge multiple instruction fields into a single effective instruction field.

Abstract: Methods and systems for performing hardware computations of mathematical functions are provided. In one example, a system comprises a mapping table that maps each base value of a plurality of base values to parameters related to a mathematical function; a selection module configured to select, based on an input value, a first base value and first parameters mapped to the first base value in the mapping table; and arithmetic circuits configured to: receive, from the mapping table, the first base value and the first plurality of parameters; and compute, based on a relationship between the input value and the first base value, and based on the first parameters, an estimated output value of the mathematical function for the input value.

Abstract: The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides. Compositions include nucleic acid compositions and protein compositions with affinity binding pairs, including metal binding peptides and immobilized metals, or peptide affinity groups.

Abstract: The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides. Compositions include nucleic acid compositions and protein compositions with affinity binding pairs, including metal binding peptides and immobilized metals, or peptide affinity groups.

Abstract: The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides. Compositions include nucleic acid compositions and protein compositions with affinity binding pairs, including metal binding peptides and immobilized metals, or peptide affinity groups.

Abstract: Three bodies interact to drive a transmission having a pair of one-way clutches coupling a single length of drive chain or other elongate flexible member to an intermeshed pair of counter rotatable gears so as to drive a primary shaft in a single rotational direction. The three bodies are a fixed body, a floating body, and a suspended and usually submerged weighted body. The three bodies are interconnected by the single length of the elongate flexible member and are spaced apart there along. The weighted body is mounted at one end of the elongate flexible member. The primary shaft is mounted above the surface of a moving fluid mass to either the fixed or floating body. The end of the flexible member opposite to the weight is mounted to the other of the fixed or floating body.

Abstract: The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula A(B)n, wherein A is a fluorophore, B is a binding domain that is a charged chemical moiety, a protein or fragment thereof and n is an integer from 1-6 with the proviso that the protein or fragment thereof not be an antibody or generated from an antibody. The present invention provides specific fluorescent compounds and methods used to detect and label fusion proteins that contain a poly-histidine affinity tag. These compounds have the general formula A(L)m(B)n wherein A is a fluorophore, L is a linker, B is an acetic acid binding domain, m is an integer from 1 to 4 and n is an integer from 1 to 6.

Abstract: The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula A(B)n, wherein A is a fluorophore, B is a binding domain that is a charged chemical moiety, a protein or fragment thereof and n is an integer from 1-6 with the proviso that the protein or fragment thereof not be an antibody or generated from an antibody. The present invention provides specific fluorescent compounds and methods used to detect and label fusion proteins that contain a poly-histidine affinity tag. These compounds have the general formula A(L)m(B)n wherein A is a fluorophore, L is a linker, B is an acetic acid binding domain, m is an integer from 1 to 4 and n is an integer from 1 to 6.

Abstract: The invention describes methods for labeling or detecting of immobilized poly(amino acids), including peptides, polypeptides and proteins, on membranes and other solid supports, using fluorescent dipyrrometheneboron difluoride dyes. Such immobilized poly(amino acids) are labeled or detected on blots or on arrays of poly(amino acids), or are attached to immobilized aptamers.

Abstract: The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula A(B)n, wherein A is a fluorophore, B is a binding domain that is a charged chemical moiety, a protein or fragment thereof and n is an integer from 1-6 with the proviso that the protein or fragment thereof not be an antibody or generated from an antibody. The present invention provides specific fluorescent compounds and methods used to detect and label fusion proteins that contain a poly-histidine affinity tag. These compounds have the general formula A(L)m(B)n wherein A is a fluorophore, L is a linker, B is an acetic acid binding domain, m is an integer from 1 to 4 and n is an integer from 1 to 6.

Abstract: The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula A(B)n, wherein A is a fluorophore, B is a binding domain that is a charged chemical moiety, a protein or fragment thereof and n is an integer from 1-6 with the proviso that the protein or fragment thereof not be an antibody or generated from an antibody. The present invention provides specific fluorescent compounds and methods used to detect and label fusion proteins that contain a poly-histidine affinity tag. These compounds have the general formula A(L)m(B)n wherein A is a fluorophore, L is a linker, B is an acetic acid binding domain, m is an integer from 1 to 4 and n is an integer from 1 to 6.

Abstract: Three bodies interact to drive a transmission having a pair of one-way clutches coupling a single length of drive chain or other elongate flexible member to an intermeshed pair of counter rotatable gears so as to drive a primary shaft in a single rotational direction. The three bodies are a fixed body, a floating body, and a suspended and usually submerged weighted body. The three bodies are interconnected by the single length of the elongate flexible member and are spaced apart there along. The weighted body is mounted at one end of the elongate flexible member. The primary shaft is mounted above the surface of a moving fluid mass to either the fixed or floating body. The end of the flexible member opposite to the weight is mounted to the other of the fixed or floating body.