Patents by Inventor Wayne R. Kindsvogel

Wayne R. Kindsvogel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10772507
    Abstract: Breast monitoring systems are described including a breast sensor device having a substrate fabricated to substantially conform to one or more breasts of a subject, dynamically bendable optical fibers, and a connector; a light source configured to operably couple with the optical fibers through the connector; a photodetector configured to operably couple with the optical fibers through the connector and positioned to detect light transmission through the optical fibers; a reporting device; and a microcontroller including a microprocessor and circuitry, the circuitry including input circuitry configured to receive a first set of signals and at least one second set of signals from the photodetector; calculation circuitry configured to calculate a curvature delta value based on a comparison of the first and at least one second set of signals, and calculate a breast volume delta value from the calculated curvature delta value; and reporting circuitry.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: September 15, 2020
    Assignee: Elwha LLC
    Inventors: Eleanor V. Goodall, Roderick A. Hyde, Wayne R. Kindsvogel, Elizabeth A. Sweeney, Charles Whitmer
  • Patent number: 10745468
    Abstract: Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin capable of binding to a first antigen and at least one endogenous secreted immunoglobulin capable of binding to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: August 18, 2020
    Assignee: Kota Biotherapeutics, LLC
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Publication number: 20200245922
    Abstract: Breast monitoring systems and methods are described including a flexible substrate fabricated to substantially conform to one or more breasts of a subject; dynamically bendable optical fibers associated with the flexible substrate; a light source operably coupled to the optical fibers; a photodetector positioned to detect light reception from the optical fibers; a reporting device; and a microcontroller including a microprocessor and circuitry, wherein the circuitry includes input circuitry configured to receive a first set of signals and at least one second set of signals from the photodetector; calculation circuitry configured to calculate a curvature delta value based on a comparison of the received first and at least one second set of signals, and calculate a breast volume delta value from the calculated curvature delta value; and reporting circuitry configured to transmit a signal to the reporting device based on the calculated breast volume delta value.
    Type: Application
    Filed: April 23, 2020
    Publication date: August 6, 2020
    Inventors: Eleanor V. Goodall, Roderick A. Hyde, Wayne R. Kindsvogel, Elizabeth A. Sweeney, Charles Whitmer
  • Patent number: 10667742
    Abstract: Breast monitoring systems and methods are described including a flexible substrate fabricated to substantially conform to one or more breasts of a subject; dynamically bendable optical fibers associated with the flexible substrate; a light source operably coupled to the optical fibers; a photodetector positioned to detect light reception from the optical fibers; a reporting device; and a microcontroller including a microprocessor and circuitry, wherein the circuitry includes input circuitry configured to receive a first set of signals and at least one second set of signals from the photodetector; calculation circuitry configured to calculate a curvature delta value based on a comparison of the received first and at least one second set of signals, and calculate a breast volume delta value from the calculated curvature delta value; and reporting circuitry configured to transmit a signal to the reporting device based on the calculated breast volume delta value.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: June 2, 2020
    Assignee: Elwha LLC
    Inventors: Eleanor V. Goodall, Roderick A. Hyde, Wayne R. Kindsvogel, Elizabeth A. Sweeney, Charles Whitmer
  • Patent number: 10597442
    Abstract: Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin capable of binding to a first antigen and at least one endogenous secreted immunoglobulin capable of binding to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: March 24, 2020
    Assignee: Kota Biotherapeutics, LLC
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Publication number: 20190352385
    Abstract: Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin capable of binding to a first antigen and at least one endogenous secreted immunoglobulin capable of binding to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
    Type: Application
    Filed: July 26, 2019
    Publication date: November 21, 2019
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Publication number: 20190153388
    Abstract: Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
    Type: Application
    Filed: January 24, 2019
    Publication date: May 23, 2019
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Publication number: 20190091263
    Abstract: Embodiments described herein relate to methods, devices, and computer systems thereof for the derivation of T CAR libraries (Universal Subject or Individual Subject) for personalized treatment of disease in a subject. In certain embodiments, differential screening of normal and diseased tissue expression data is utilized to determine disease-specific antigens and thereby generate T CAR cells reactive to such antigens to form a disease-specific library. In certain embodiments, determination of the most effective T CAR clones from the disease-specific library is based on the subject's own disease-specific antigens. In certain embodiments, a subject is treated with a therapeutically effective amount of T CAR clones.
    Type: Application
    Filed: November 30, 2018
    Publication date: March 28, 2019
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Patent number: 10233424
    Abstract: Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: March 19, 2019
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Publication number: 20180215817
    Abstract: Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin capable of binding to a first antigen and at least one endogenous secreted immunoglobulin capable of binding to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
    Type: Application
    Filed: March 19, 2018
    Publication date: August 2, 2018
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Publication number: 20180214066
    Abstract: Breast monitoring systems and methods are described including a flexible substrate fabricated to substantially conform to one or more breasts of a subject; dynamically bendable optical fibers associated with the flexible substrate; a light source operably coupled to the optical fibers; a photodetector positioned to detect light reception from the optical fibers; a reporting device; and a microcontroller including a microprocessor and circuitry, wherein the circuitry includes input circuitry configured to receive a first set of signals and at least one second set of signals from the photodetector; calculation circuitry configured to calculate a curvature delta value based on a comparison of the received first and at least one second set of signals, and calculate a breast volume delta value from the calculated curvature delta value; and reporting circuitry configured to transmit a signal to the reporting device based on the calculated breast volume delta value.
    Type: Application
    Filed: February 1, 2017
    Publication date: August 2, 2018
    Inventors: Eleanor V. Goodall, Roderick A. Hyde, Wayne R. Kindsvogel, Elizabeth A. Sweeney, Charles Whitmer
  • Publication number: 20180214026
    Abstract: Breast monitoring systems are described including a breast sensor device having a substrate fabricated to substantially conform to one or more breasts of a subject, dynamically bendable optical fibers, and a connector; a light source configured to operably couple with the optical fibers through the connector; a photodetector configured to operably couple with the optical fibers through the connector and positioned to detect light transmission through the optical fibers; a reporting device; and a microcontroller including a microprocessor and circuitry, the circuitry including input circuitry configured to receive a first set of signals and at least one second set of signals from the photodetector; calculation circuitry configured to calculate a curvature delta value based on a comparison of the first and at least one second set of signals, and calculate a breast volume delta value from the calculated curvature delta value; and reporting circuitry.
    Type: Application
    Filed: February 1, 2017
    Publication date: August 2, 2018
    Inventors: Eleanor V. Goodall, Roderick A. Hyde, Wayne R. Kindsvogel, Elizabeth A. Sweeney, Charles Whitmer
  • Patent number: 9956106
    Abstract: A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including a layered wall, the flexible tubular structure including a plurality of at least one type of commensal microbe encased in the layered wall, the layered wall configured to allow an interaction between the plurality of the at least one type of commensal microbe and an ingested product within the flexible tubular structure, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: May 1, 2018
    Assignee: Elwha LLC
    Inventors: Mahalaxmi Gita Bangera, William David Duncan, Roderick A. Hyde, Wayne R. Kindsvogel, Elizabeth A. Sweeney
  • Patent number: 9949855
    Abstract: A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including a layered wall, the flexible tubular structure including at least one microbe-promoting agent encased in the layered wall, the microbe-promoting agent configured to promote at least one of attraction, colonization, and growth of at least one type of commensal microbe, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: April 24, 2018
    Assignee: Elwha LLC
    Inventors: Mahalaxmi Gita Bangera, William David Duncan, Roderick A. Hyde, Wayne R. Kindsvogel, Elizabeth A. Sweeney
  • Patent number: 9901598
    Abstract: Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated B lymphocyte cell line. An isolated recombinant cell line includes an isolated B lymphocyte cell line capable of expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and at least one exogenously incorporated nucleic acid encoding at least one secreted immunoglobulin reactive to a second antigen.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: February 27, 2018
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel
  • Patent number: 9845351
    Abstract: Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: December 19, 2017
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel
  • Publication number: 20170238488
    Abstract: Various embodiments disclosed herein include systems, methods, compositions, and products by process for Rapid-breeding of plants. In certain embodiments, the systems and/or methods are at least partially automated.
    Type: Application
    Filed: May 9, 2017
    Publication date: August 24, 2017
    Inventors: Mahalaxmi Gita Bangera, Philip A. Eckhoff, Roderick A. Hyde, Edward K. Y. Jung, Wayne R. Kindsvogel, Lowell L. Wood, JR.
  • Publication number: 20170224735
    Abstract: Embodiments described herein relate to methods, devices, and computer systems thereof for the derivation of T CAR libraries (Universal Subject or Individual Subject) for personalized treatment of disease in a subject. In certain embodiments, differential screening of normal and diseased tissue expression data is utilized to determine disease-specific antigens and thereby generate T CAR cells reactive to such antigens to form a disease-specific library. In certain embodiments, determination of the most effective T CAR clones from the disease-specific library is based on the subject's own disease-specific antigens. In certain embodiments, a subject is treated with a therapeutically effective amount of T CAR clones.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 10, 2017
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Patent number: 9717618
    Abstract: A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including an inner surface and an outer surface, a plurality of at least one type of commensal microbe associated with at least a portion of at least one of the inner surface and the outer surface, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: August 1, 2017
    Assignee: Elwha LLC
    Inventors: Mahalaxmi Gita Bangera, William David Duncan, Roderick A. Hyde, Wayne R. Kindsvogel, Elizabeth A. Sweeney
  • Patent number: 9707116
    Abstract: A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including an inner surface and an outer surface, at least one microbe-promoting agent associated with at least one of the inner surface and the outer surface, the at least one microbe-promoting agent configured to promote attraction, colonization, and growth of at least one type of commensal microbe, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: July 18, 2017
    Assignee: Elwha LLC
    Inventors: Mahalaxmi Gita Bangera, William David Duncan, Roderick A. Hyde, Wayne R. Kindsvogel, Elizabeth A. Sweeney