Abstract: A microphysiological system (MPS) includes at least one first inlet for receiving a fluid medium. The MPS includes a brain module comprising brain tissue. The MPS includes a blood-brain-barrier (BBB) module comprising BBB tissue, the BBB module configured to receive the fluid medium. The MPS includes a crosstalk channel between the brain module and the BBB module, the crosstalk channel configured to promote a bidirectional crosstalk between the brain tissue and the BBB tissue in response to receiving the fluid medium at the BBB module. The MPS is configured for treating the brain tissue and the BBB tissue with a drug or a combination of drugs to determine a phenotypic effect and a transcriptomic effect of the drug. A drug perturbation is related to the phenotypic effect and the transcriptomic effect based on kinetic optimization.

Abstract: A microphysiological system (MPS) includes at least one first inlet for receiving a fluid medium. The MPS includes a brain module comprising brain tissue. The MPS includes a blood-brain-barrier (BBB) module comprising BBB tissue, the BBB module configured to receive the fluid medium. The MPS includes a crosstalk channel between the brain module and the BBB module, the crosstalk channel configured to promote a bidirectional crosstalk between the brain tissue and the BBB tissue in response to receiving the fluid medium at the BBB module. The MPS is configured for treating the brain tissue and the BBB tissue with a drug or a combination of drugs to determine a phenotypic effect and a transcriptomic effect of the drug. A drug perturbation is related to the phenotypic effect and the transcriptomic effect based on kinetic optimization.

Abstract: A method for developing stratified medicine for nonalcoholic fatty liver disease (NAFLD includes obtaining a microphysiological system (MPS) comprising a liver tissue cytoarchitecture, adipose tissue, or both. The method includes inducing metabolic dysfunction representing NAFLD in the liver or adipose tissue of the MPS. The method includes generating, based on inducing the metabolic dysfunction, transcriptomics data for the MPS. The method includes applying a drug to the MPS using a dosing regimen. The method includes monitoring changes in the transcriptomics data based on applying the drug. The method includes generating a model relating the changes in the transcriptomics data to the dosing regimen of the drug.

Abstract: A microphysiological system (MPS) includes at least one first inlet for receiving a fluid medium. The MPS includes a brain module comprising brain tissue. The MPS includes a blood-brain-barrier (BBB) module comprising BBB tissue, the BBB module configured to receive the fluid medium. The MPS includes a crosstalk channel between the brain module and the BBB module, the crosstalk channel configured to promote a bidirectional crosstalk between the brain tissue and the BBB tissue in response to receiving the fluid medium at the BBB module. The MPS is configured for treating the brain tissue and the BBB tissue with a drug or a combination of drugs to determine a phenotypic effect and a transcriptomic effect of the drug. A drug perturbation is related to the phenotypic effect and the transcriptomic effect based on kinetic optimization.

Abstract: An apparatus includes a mirror head assembly including a rearwardly-extending ball section, and a mirror support assembly including a tube having a larger-diameter mid-section and a smaller-diameter tapered end section. A socket on the mirror support assembly, when in the end section, captures the ball section with friction to permit angular adjustment but with enough friction to maintain a selected angular position. A spring biases the socket from the mid-section into the end section, but is compressible so that assembly is possible by pressing the ball section against the socket, causing the socket to move from the end section into the mid-section where the ball section snaps into the socket. It is conceived that the ball section and socket components can be reversed, and also that the mirror support assembly can include a two-ball mount, with a ball-and-socket connection at each end.

Abstract: A vehicle communication and control system is provided that may be more readily installed in a vehicle and that utilizes minimal additional wiring. According to some of the disclosed embodiments, the electrical components of the “brick” of a communication and control system are integrated into a rearview mirror assembly. Preferably, the microwave antenna for the GPS and the cellular telephone antenna are also integrated into the rearview mirror assembly. Various functions and features of the system are also disclosed.

Abstract: An electrochromic mirror includes an integrated internal plate frame with an electrochromic mirror subassembly adhered to its flat front surface, electrical components supported on a rear with the frame acting as a heat sink and EMI/RFI shield, and a back cover supported on the plate frame. The subassembly is uniformly supported across the front surface of the plate frame for good mirror impact resistance. The mirror is supported by an angularly adjustable ball-and-socket connection. In one embodiment, the ball is formed integrally on the plate frame. The present mirror is surprisingly thin, with at least 50% of the depth dimensions being less than about 3.0 centimeters.

Abstract: A vehicle communication and control system is provided that may be more readily installed in a vehicle and that utilizes minimal additional wiring. According to some of the disclosed embodiments, the electrical components of the “brick” of a communication and control system are integrated into a rearview mirror assembly. Preferably, the microwave antenna for the GPS and the cellular telephone antenna are also integrated into the rearview mirror assembly. Various functions and features of the system are also disclosed.

Abstract: A rearview assembly comprising a rearview element, a rearview element support assembly supporting the rearview element and a mount adjacent the housing. The mount is configured to connect the rearview assembly to a windshield. At least one of the rearview element support assembly and the mount comprises a crush bracket having at least two legs adapted to be compressed as a force strikes a front of the rearview element. The crush bracket can include at least one tab contacting a heat emitting component and/or an electrically conductive component of a circuit to provide a heat sink for the heat emitting component or a ground for the electrically conductive component, respectively.

Abstract: An electrochromic mirror includes an integrated internal plate frame with an electrochromic mirror subassembly adhered to its flat front surface, electrical components supported on a rear with the frame acting as a heat sink and EMI/RFI shield, and a back cover supported on the plate frame. The subassembly is uniformly supported across the front surface of the plate frame for good mirror impact resistance. The mirror is supported by an angularly adjustable ball-and-socket connection. In one embodiment, the ball is formed integrally on the plate frame. The present mirror is surprisingly thin, with at least 50% of the depth dimensions being less than about 3.0 centimeters.

Abstract: A rearview mirror subassembly for a vehicle comprising a housing and a reflective element in the housing. An elastomer abuts against at least a portion of the reflective element to thereby maintain the reflective element in position within the housing.

Abstract: A rearview assembly of the present invention may include a housing adapted to be mounted to the vehicle, a rearview element disposed in the housing for providing an image to the driver of the rearward view from the vehicle, and a glare sensor positioned to receive light from passing through the rearview element. The glare sensor may be a surface-mounted to a circuit board. An optional secondary optical element may be disposed between the rearview element and the glare sensor. The optional secondary optical element may have an anamorphic lens for providing different fields of view horizontally versus vertically.

Abstract: An interior rearview mirror assembly comprising a plate frame, a mirror adjacent a front of the plate frame, a pivot ball connected to the plate frame for pivoting the plate frame, and a mount connected to the pivot ball and configured to be connected to a windshield of a vehicle. At least one of the plate frame, the pivot ball and the mount are made of a material comprising a magnesium alloy.

Abstract: An electrochromic mirror includes an integrated internal plate frame with an electrochromic mirror subassembly adhered to its flat front surface, electrical components supported on a rear with the frame acting as a heat sink and EMI/RFI shield, and a back cover supported on the plate frame. The subassembly is uniformly supported across the front surface of the plate frame for good mirror impact resistance. The mirror is supported by an angularly adjustable ball-and-socket connection. In one embodiment, the ball is formed integrally on the plate frame. The present mirror is surprisingly thin, with at least 50% of the depth dimensions being less than about 3.0 centimeters.

Abstract: An apparatus includes a mirror head assembly including a rearwardly-extending ball section, and a mirror support assembly including a tube having a larger-diameter mid-section and a smaller-diameter tapered end section. A socket on the mirror support assembly, when in the end section, captures the ball section with friction to permit angular adjustment but with enough friction to maintain a selected angular position. A spring biases the socket from the mid-section into the end section, but is compressible so that assembly is possible by pressing the ball section against the socket, causing the socket to move from the end section into the mid-section where the ball section snaps into the socket. It is conceived that the ball section and socket components can be reversed, and also that the mirror support assembly can include a two-ball mount, with a ball-and-socket connection at each end.

Abstract: A mirror construction includes an interior rearview mirror housing having a socket, and includes a mirror mount having a ball section that angularly and adjustably engages the socket to form a ball connection. The ball section has a radially open portion permitting wiring to be laid laterally into the ball section to facilitate assembly. A wedge fits in the open portion for holding the open portion so that the ball connection cannot distort and collapse over time. The mount includes a window for snap-attachment of an electrical connector for the wiring.