Patents by Inventor Wayne T. Hockmeyer

Wayne T. Hockmeyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccines for the malaria circumsporozoite protein
    Patent number: 5112749
    Abstract: The present invention is directed to attenuated strains of enteroinvasive bacteria that express a peptide or protein related to an epitope of the malaria parasites of the genus Plasmodium. The bacterial strains of the invention which can multiply in a host without causing significant disease or disorder, and which express a Plasmodium-related peptide that induces a protective immune response against malaria, can be used in live vaccine formulations for malaria. In specific embodiments, a Plasmodium-related peptide can be expressed as a fusion protein, for example, with a bacterial enterotoxin.The invention also relates to methods for expression of malaria antigens or fragments thereof within attenuated enteroinvasive bacteria.In particular embodiments, the invention is directed to the expression by attenuated Salmonella spp. of epitopes of Plasmodium circumsporozoite proteins.
    Type: Grant
    Filed: October 2, 1987
    Date of Patent: May 12, 1992
    Assignee: Praxis Biologics, Inc.
    Inventors: Robert N. Brey, III, William R. Majarian, Subramonia Pillai, Wayne T. Hockmeyer