Patents by Inventor Wee Joo CHNG

Wee Joo CHNG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Predicting a Suitable Therapy
    Publication number: 20220367023
    Abstract: The invention relates to a method for predicting, selecting and screening a personalised combinatorial therapy for a patient comprising the steps of measuring a response output for each drug candidate in a sample obtained from the patient; determining a minimum set of test combinatorial therapies according to a composite experimental design, such as an orthogonal array composite design; measuring a response output and determining a relationship between the response output and the corresponding predetermined doses of the candidate drugs; and consequently deriving an optimal drug-dose combination for treating the patient.
    Type: Application
    Filed: October 16, 2020
    Publication date: November 17, 2022
    Inventors: Edward Kai-Hua Chow, Wee Joo Chng, Anand Devaprasath Jeyasekharan, Sanjay De Mel, Masturah Mohd Abdul Rashid
  • Anti oligosaccharide antibody
    Patent number: 11124579
    Abstract: An antigen-binding protein, or an antigen-binding fragment thereof that binds to a Lewis X type glycan on SLAMF7, comprising (1) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYTFTSYWIH; a VHCDR2 having the amino acid sequence EINPSNGRTNFNEKFKN and a VHCDR3 having the amino acid sequence VDYDEAY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence RSSKSLLHSNGITYLY, a VLCDR2 having the amino acid sequence QMSNLAS, and a VLCDR3 having the amino acid sequence AQNLELWT is provided. Methods of using the antibody for detecting or treating cancer, and a kit comprising the antibody are also provided.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: September 21, 2021
    Assignees: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Chong Kok Teo, Andre Boon Hwa Choo, Wee Joo Chng
  • ANTI OLIGOSACCHARIDE ANTIBODY
    Publication number: 20200024359
    Abstract: An antigen-binding protein, or an antigen-binding fragment thereof that binds to a Lewis X type glycan on SLAMF7, comprising (1) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYTFTSYWIH; a VHCDR2 having the amino acid sequence EINPSNGRTNFNEKFKN and a VHCDR3 having the amino acid sequence VDYDEAY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence RSSKSLLHSNGITYLY, a VLCDR2 having the amino acid sequence QMSNLAS, and a VLCDR3 having the amino acid sequence AQNLELWT is provided. Methods of using the antibody for detecting or treating cancer, and a kit comprising the antibody are also provided.
    Type: Application
    Filed: March 29, 2018
    Publication date: January 23, 2020
    Inventors: Chong Kok Teo, Andre Boon Hwa Choo, Wee Joo Chng
  • IMPROVED DRUG COMBINATIONS FOR DRUG-RESISTANT AND DRUG-SENSITIVE MULTIPLE MYELOMA
    Publication number: 20190125772
    Abstract: Disclosed are pharmaceutical compositions and methods of treating multiple myeloma by providing a pharmaceutically effective amount of each drug in a combination of drugs.
    Type: Application
    Filed: May 4, 2016
    Publication date: May 2, 2019
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Dean HO, Chih-Ming HO, Aleidy Marlene Silva VITE, Kangyi ZHANG, Edward Kai-Hua CHOW, Tan Boon TOH, Wee Joo CHNG, Masturah Mohd Abdul RASHID