Patents by Inventor WEI-CHEN HSIEH

WEI-CHEN HSIEH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small interfering RNA and pharmaceutical composition and method for inhibiting galectin-12 expression and/or enhancing lipolysis containing the same
    Patent number: 9777273
    Abstract: A small interfering RNA is provided. The small interfering RNA consists of a passenger strand and a guide strand, wherein the sequence of the passenger strand comprises the sequence of SEQ ID NO. 7, and the sequence of the guide strand comprises the sequence of SEQ ID NO. 8, wherein the small interfering RNA is capable of inhibiting galectin-12 expression.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: October 3, 2017
    Assignees: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, ACADEMIA SINICA
    Inventors: Yen-Ju Lin, Jui-Wen Huang, Fu-Tong Liu, Huan-Yuan Chen, Wei-Chen Hsieh
  • SMALL INTERFERING RNA AND PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITING GALECTIN-12 EXPRESSION AND/OR ENHANCING LIPOLYSIS CONTAINING THE SAME
    Publication number: 20170159051
    Abstract: A small interfering RNA is provided. The small interfering RNA consists of a passenger strand and a guide strand, wherein the sequence of the passenger strand comprises the sequence of SEQ ID NO. 7, and the sequence of the guide strand comprises the sequence of SEQ ID NO. 8, wherein the small interfering RNA is capable of inhibiting galectin-12 expression.
    Type: Application
    Filed: August 5, 2015
    Publication date: June 8, 2017
    Applicants: Industrial Technology Research Institute, Academia Sinica
    Inventors: Yen-Ju LIN, Jui-Wen HUANG, Fu-Tong LIU, Huan-Yuan CHEN, Wei-Chen HSIEH
  • Reducing galectin-12 activity to influence the cell function of human sebocytes
    Patent number: 9121021
    Abstract: Methods for the treatment of a disorder characterized by excessive proliferation and/or lipid content of sebocytes are disclosed. In one embodiment of the invention, the method comprises administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a small molecule inhibitor targeted to galectin-12 or a nucleic acid-based inhibitor targeted to galectin-12 and a pharmaceutically acceptable carrier, wherein said inhibitor is a non-naturally occurring molecule and administration of said inhibitor produces a decrease in the proliferation and/or lipid content of the sebocytes. Methods for decreasing sebaceous gland size, inhibiting sebocyte proliferation, and/or inhibiting sebocyte lipid content are also disclosed.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: September 1, 2015
    Assignee: ACADEMIA SINICA
    Inventors: Fu-Tong Liu, Wei-Chen Hsieh, Ri-Yao Yang
  • REDUCING GALECTIN-12 ACTIVITY TO INFLUENCE THE CELL FUNCTION OF HUMAN SEBOCYTES
    Publication number: 20150126583
    Abstract: Methods for the treatment of a disorder characterized by excessive proliferation and/or lipid content of sebocytes are disclosed. In one embodiment of the invention, the method comprises administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a small molecule inhibitor targeted to galectin-12 or a nucleic acid-based inhibitor targeted to galectin-12 and a pharmaceutically acceptable carrier, wherein said inhibitor is a non-naturally occurring molecule and administration of said inhibitor produces a decrease in the proliferation and/or lipid content of the sebocytes. Methods for decreasing sebaceous gland size, inhibiting sebocyte proliferation, and/or inhibiting sebocyte lipid content are also disclosed.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 7, 2015
    Inventors: FU-TONG LIU, WEI-CHEN HSIEH, RI-YAO YANG