Abstract: The present disclosure relates to compounds targeting kinases such as EGFR, pharmaceutical compositions containing the compounds, and methods of using such compounds to treat disease, such as cancer.

Abstract: A system and method for separating oil and water is disclosed using a flotation tank having an contaminated water inlet, an oil outlet, and a water outlet and a bubble generator operably connected to the bubble inlet and operable to supply a quantity of bubbles into the interior of the flotation tank, wherein the oil outlet removes a quantity of oil collected by the bubbles from the interior of the flotation tank and the water outlet removes a quantity of the water having the oil removed therefrom from the interior of the flotation tank. The system further comprises an adsorption tank containing a quantity of an oil-absorbing material selectably connected to water outlet and a sensor operable cause water exiting the flotation tank through the water outlet to be directed to the adsorption tank when the concentration of oil in the water exiting the flotation tank exceeds a predetermined value.

Abstract: An imaging system includes a pixel array configured to generate image charge voltage signals in response to incident light received from an external scene. An infrared illumination source is deactivated during the capture of a first image of the external scene and activated during the capture of a second image of the external scene. An array of sample and hold circuits is coupled to the pixel array. Each sample and hold circuit is coupled to a respective pixel of the pixel array and includes first and second capacitors to store first and second image charge voltage signals of the captured first and second images, respectively. A column voltage domain differential amplifier is coupled to the first and second capacitors to determine a difference between the first and second image charge voltage signals to identify an object in a foreground of the external scene.

Abstract: Image sensors for Phase-Detection Auto Focus (PDAF) are provided. An image sensor includes a pixel including a plurality of photodiodes disposed in a semiconductor material according to an arrangement. The arrangement defines a first image subpixel comprising a plurality of first photodiodes, a second image subpixel comprising a plurality of second photodiodes, and a third image subpixel including a plurality of third photodiodes, and a phase detection subpixel comprising a first photodiode, a second photodiode, or a third photodiodes. The pixel can include a plurality of first micro-lenses disposed individually overlying at least a subset of the plurality of photodiodes of the first, second and third image subpixels. The pixel can also include a second micro-lens disposed overlying the phase detection subpixel, a first micro-lens of the first micro-lenses having a first radius less than a second radius of the second micro-lens.

Abstract: Provided are a display panel and a display device. The display panel includes: a via hole penetrating through the display panel; a cutting residual area on the periphery of the via hole and includes a base substrate, and a packaging layer; and at least one annular relief structure between the packaging layer and the base substrate in the cutting residual area. The at least one annular relief structure is sequentially distributed around the via hole. At least one relief structure is provided with a surface facing away from the base substrate, and a side face connected to the surface, at least one of the surface and the side face is of a relief shape. The first relief structure is the relief structure with a smallest distance from the center of the via hole.

Abstract: Tricyclic compounds of formula (I), pharmaceutical compositions comprising same, methods for preparing same, and uses thereof, wherein each variable is as defined in the description.

Abstract: An embodiment of the present disclosure provides a plugin adding method and apparatus, an electronic device, and a storage medium. The method comprises: presenting a target page, wherein at least one plugin adding area is provided in the target page; receiving a plugin adding operation acting on the plugin adding area, and presenting a plugin editing area corresponding to the plugin adding operation; and receiving a plugin editing operation acting on the plugin editing area, generating a target plugin based on edited plugin information, and adding the target plugin to the plugin adding area.

Abstract: The display panel includes: a via hole penetrating through the display panel; a cutting residual region, and a packaging layer located on one side of the base substrate; and at least one circle relief structure located between the packaging layer and the base substrate of the cutting residual region. The at least one circle relief structure is distributed around the via hole. The smallest distance between a first relief structure and the outer edge of the via hole ranges from 0 to 30 micrometers. At least one relief structure is provided with a surface facing away from the base substrate, and a side face connected to the surface, where at least one of the surface and the side face is of a relief shape. The first relief structure is a relief structure with a smallest distance from a center of the via hole.

Abstract: A firewall receives bypass traffic obtained by performing a copy operation on the network traffic, and detects a packet in the bypass traffic, to obtain a packet control message. The firewall control module receives the packet control message sent by the firewall, and performs a target operation such as forwarding, discarding, or buffering on a target packet in the plurality of packets. In this method, the firewall deployed in a bypass manner parses data in parallel, and the firewall control module does not need to parse any data.

Abstract: Provided are a display panel and a display device. The display panel includes: a via hole penetrating through the display panel; a cutting residual area on the periphery of the via hole and includes a base substrate, and a packaging layer: and at least one annular relief structure between the packaging laver and the base substrate in the cutting residual area. The at least one annular relief structure is sequentially distributed around the via hole. At least one relief structure is provided with a surface facing away from the base substrate, and a side face connected to the surface, at least one of the surface and the side face is of a relief shape. The first relief structure is the relief structure with a smallest distance from the center of the via hole.

Abstract: An extensible rod with locking handle for goods comprises an inner tube, an outer tube, a rack, a hollow seat, an operating assembly and a lock catch assembly. The rack is disposed on the inner tube inside the outer tube, the operating assembly comprising a rotatable handle and a gear with a plurality of teeth connected to the handle is used for adjusting extension length of the inner tube, the teeth on the gear pass through the outer tube to engage with the rack on the inner tube, so that the handle and the gear are capable of driving the inner tube to extend out from or retract into the outer tube, the lock catch assembly is capable of locking or unlocking the handle. Under this design, the stability is high, and it is difficult to damage. Meanwhile, the defects of the existing extensible rod with locking handle for goods are effectively solved.

Abstract: The present disclosure provides methods and kits for diagnosing and assessing SAGE1-positive disorders, and compositions and methods for treating SAGE1-positive disorders. The present disclosure further provides SAGE1 complexes and methods and composition for inhibiting SAGE1 complexes and treating SAGE1-positive disorders.

Abstract: A method for generating image data from a pixel cell of an image sensor includes pulsing a reset gate, of the pixel cell, that includes a zeroth pixel and a first pixel; generating a signal from the pixel cell by sequentially pulsing a zeroth transfer gate and a first transfer gate of the zeroth pixel and the first pixel, respectively; and abstaining from pulsing the reset gate of the pixel cell until each of the zeroth and the first transfer gate has been pulsed; sampling the signal to yield signals S0 and S1 and a reset-signal RST; determining a binned signal as a difference between signal S1 and reset-signal RST; determining a pixel signal PD0, output from the zeroth pixel, as a difference between signal S0 and reset-signal RST; and determining a pixel signal PD1, output from the first pixel, as a difference signal S1 and signal S0.

Abstract: An image sensor including one or more pixels is provided. At least one of the pixels can include a semiconductor substrate, a floating diffusion formed in the semiconductor substrate, a transfer gate configured to selectively cause transfer of photo-charges stored in the pixel to the floating diffusion, and a multigate source follower. The multigate source follower can include a channel, a source and a drain coupled by the channel, a modulation gate formed over the channel and coupled to the floating diffusion, and a first guard gate formed over the channel.

Abstract: Half Quad Photodiode (QPD) for improving QPD channel imbalance. In one embodiment, an image sensor includes a plurality of pixels arranged in rows and columns of a pixel array that is disposed in a semiconductor material. Each pixel includes a plurality of subpixels. Each subpixel comprises a plurality of first photodiodes, a plurality of second photodiodes and a plurality of third photodiodes. The plurality of pixels are configured to receive incoming light through an illuminated surface of the semiconductor material. A plurality of small microlenses are individually distributed over individual first photodiodes and individual second photodiodes of each subpixel. A plurality of large microlenses are each distributed over a plurality of third photodiodes of each subpixel. A diameter of the small microlenses is smaller than a diameter of the large microlenses.

Abstract: The present invention relates to pyrimidinone compounds and uses thereof. In particular, the present invention relates to pyrimidinone compounds of formula (I), pharmaceutical compositions comprising same, methods for preparing same, and uses thereof, wherein the variables are as defined in the description.

Abstract: The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSF1R, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.

Abstract: The present disclosure relates to indazole macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as cancer comprising administering a therapeutically effective amount of a compound to a subject in need thereof.

Abstract: A display panel, a display apparatus, and a manufacture method are provided. The display panel includes a transparent substrate, and a first display region and a second display region which are both located on the transparent substrate, wherein a plurality of first light-emitting device units arranged in array are provided in the first display region, a plurality of first driving units arranged in array are provided in the second display region, and each of the first driving units is connected to one of the first light-emitting device units via a connection wire, and drives the first light-emitting device unit to emit light; wherein the connection wire is manufactured on an inorganic protective layer.

Abstract: A fast-connecting safety tensioning device for automobiles comprises a main body which consists of a base assembly, a handle assembly and a rolling assembly; and a band. The base assembly comprises a base, the rolling assembly comprises a spindle for mounting the band, the spindle is mounted on the base. The base has one or more threaded holes on a bottom of the base for one or more screws to pass through so as to quickly mount the fast-connecting safety tensioning device onto an object to be fixed in place (for example, a sidewall B of the pickup truck, the trailer trestle A, the car deck, etc.). One or more rivet nuts each having one threaded hole are integrally formed on the bottom of the base. The connection stability and the bearing capacity are greatly improved. Technical problems of the existing tensioning device can be effectively solved.