Abstract: The present disclosure provides methods and kits for diagnosing and assessing SAGE1-positive disorders, and compositions and methods for treating SAGE1-positive disorders. The present disclosure further provides SAGE1 complexes and methods and composition for inhibiting SAGE1 complexes and treating SAGE1-positive disorders.

Abstract: A method for generating image data from a pixel cell of an image sensor includes pulsing a reset gate, of the pixel cell, that includes a zeroth pixel and a first pixel; generating a signal from the pixel cell by sequentially pulsing a zeroth transfer gate and a first transfer gate of the zeroth pixel and the first pixel, respectively; and abstaining from pulsing the reset gate of the pixel cell until each of the zeroth and the first transfer gate has been pulsed; sampling the signal to yield signals S0 and S1 and a reset-signal RST; determining a binned signal as a difference between signal S1 and reset-signal RST; determining a pixel signal PD0, output from the zeroth pixel, as a difference between signal S0 and reset-signal RST; and determining a pixel signal PD1, output from the first pixel, as a difference signal S1 and signal S0.

Abstract: An image sensor including one or more pixels is provided. At least one of the pixels can include a semiconductor substrate, a floating diffusion formed in the semiconductor substrate, a transfer gate configured to selectively cause transfer of photo-charges stored in the pixel to the floating diffusion, and a multigate source follower. The multigate source follower can include a channel, a source and a drain coupled by the channel, a modulation gate formed over the channel and coupled to the floating diffusion, and a first guard gate formed over the channel.

Abstract: Half Quad Photodiode (QPD) for improving QPD channel imbalance. In one embodiment, an image sensor includes a plurality of pixels arranged in rows and columns of a pixel array that is disposed in a semiconductor material. Each pixel includes a plurality of subpixels. Each subpixel comprises a plurality of first photodiodes, a plurality of second photodiodes and a plurality of third photodiodes. The plurality of pixels are configured to receive incoming light through an illuminated surface of the semiconductor material. A plurality of small microlenses are individually distributed over individual first photodiodes and individual second photodiodes of each subpixel. A plurality of large microlenses are each distributed over a plurality of third photodiodes of each subpixel. A diameter of the small microlenses is smaller than a diameter of the large microlenses.

Abstract: The present invention relates to pyrimidinone compounds and uses thereof. In particular, the present invention relates to pyrimidinone compounds of formula (I), pharmaceutical compositions comprising same, methods for preparing same, and uses thereof, wherein the variables are as defined in the description.

Abstract: The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSF1R, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.

Abstract: The present disclosure relates to indazole macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as cancer comprising administering a therapeutically effective amount of a compound to a subject in need thereof.

Abstract: A display panel, a display apparatus, and a manufacture method are provided. The display panel includes a transparent substrate, and a first display region and a second display region which are both located on the transparent substrate, wherein a plurality of first light-emitting device units arranged in array are provided in the first display region, a plurality of first driving units arranged in array are provided in the second display region, and each of the first driving units is connected to one of the first light-emitting device units via a connection wire, and drives the first light-emitting device unit to emit light; wherein the connection wire is manufactured on an inorganic protective layer.

Abstract: A fast-connecting safety tensioning device for automobiles comprises a main body which consists of a base assembly, a handle assembly and a rolling assembly; and a band. The base assembly comprises a base, the rolling assembly comprises a spindle for mounting the band, the spindle is mounted on the base. The base has one or more threaded holes on a bottom of the base for one or more screws to pass through so as to quickly mount the fast-connecting safety tensioning device onto an object to be fixed in place (for example, a sidewall B of the pickup truck, the trailer trestle A, the car deck, etc.). One or more rivet nuts each having one threaded hole are integrally formed on the bottom of the base. The connection stability and the bearing capacity are greatly improved. Technical problems of the existing tensioning device can be effectively solved.

Abstract: A safety tensioning device for automobile comprises a winding assembly disposed on the base and driven by a main shaft, the winding assembly and a coil spring; a stop plate and a pressing plate disposed respectively at the front end and the rear end of the base; a driving pawl is rotatably connected to the handle. The handle is pivoted to the base and is capable of rotating about the main shaft; the base has three operating regions on the top of the base: a tensioning region, a working region and a release region, the three operating regions cooperate with the limiting block of the driving pawl. The present invention can automatically wind the first bundling strap when the first bundling strap is loose due to jolts in the operating state, so that the first bundling strap is always kept in the tensioned state, thereby preventing unhooking and greatly improving the use safety.

Abstract: Provided are an ink composition, a package structure, and a semiconductor device. The ink composition includes: a photocurable silicon-containing monomer component, an active diluent component, and a photoinitiator component, wherein the photocurable silicon-containing monomer component comprises any one or more compounds having the following structural formula (I).

Abstract: This disclosure relates to the use of certain diaryl macrocycle compounds, specifically (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one in the treatment of disease in mammals. This disclosure also relates to compositions including such compounds, and to methods of using such compositions in the treatment of diseases in mammals, especially in humans.

Abstract: A phase-locked loop, a signal processing device and a signal processing method. In the phase-locked loop, a reference clock unit outputs two or more frequency-adjustable synchronous reference clock signals to a phase discrimination unit; a feedback unit performs frequency division processing on an output voltage signal, which is output by the phase-locked loop within a first period, so as to obtain a feedback signal; the phase discrimination unit determines a corresponding error signal for each reference clock signal according to the phase difference between each reference clock signal and the feedback signal; a weighting unit performs weighting calculation on the determined error signals, so as to obtain a weighted error signal; and a correction unit is configured to correct, according to the weighted error signal, an output voltage signal, which is output by the phase-locked loop within a second period.

Abstract: Provided in the present disclosure are a method and apparatus for a terminal to access a network, an Internet of Things (IoT) system, and a computer program product. The method includes: receiving idle timeslot information of a gateway to be accessed that is sent by said gateway in a current timeslot; parsing the number of timeslots between the current timeslot and a latest idle timeslot from the idle timeslot information; determining the sleep duration of a terminal according to the number of timeslots; and sending a network access request to said gateway after sleeping until the latest idle timeslot according to the sleep duration.

Abstract: A method for determining a resource utilization rate. The method is performed by a network side device, and includes: determining the resource utilization rate by using a total number of physical resource blocks (PRBs) corrected by a layer factor, wherein the layer factor is determined according to PRB usage information of at least one sampling occasion, and the PRB usage information of the at least one sampling occasion at least comprises a number of multiple input multiple output (MIMO) layers used by a PRB in data transmission.

Abstract: Provided is a method for determining a proper plant spacing for vegetation ecological restoration in an arid region. The method includes the following steps: step 1, acquiring soil parameters and soil water parameters in a survey region; step 2, determining vegetation parameters for the survey region; step 3, collecting hydrological data of the survey region; step 4, determining a transpiration of a dominant plant species in a vegetation community of the survey region; step 5, calculating a thickness of a shallow groundwater action layer in the survey region; step 6, determining a thickness of an available water absorption layer; step 7, determining a water content within the thickness of the available water absorption layer; and step 8, determining the proper plant spacing for a vegetation. The method can effectively solve the problem of desertification of oases in arid regions.

Abstract: Provided herein are casein kinase inhibitors, or pharmaceutically acceptable salts thereof. Corresponding compositions, methods of treatment, and intermediates are also provided.

Abstract: The present invention provides a coal feeding control method and system for a small pulverized coal silo, the method includes: acquiring a boiler load increase signal, and determining the target function F(t) for boiler load control obtaining the current coal mill output signal B(t), where B(t) is the fuel quantity signal at the outlet of the coal mill that changes over time from the start time; comparing B(t) with F(t): if B(t) cannot meet the fuel quantity requirements of F(t), activate the small pulverized coal silo connected to the boiler; otherwise, the small pulverized coal silo remains inactive; determining the coal feeding signal f(t) for the small pulverized coal silo, and further determining the coal feeding control signal f(t) for the small pulverized coal silo; controlling the small pulverized coal silo to feed coal to the boiler, quickly changing the combustion rate in the furnace, and increasing the boiler load.

Abstract: The present disclosure provides a control method and device, apparatus and a storage medium. The method includes: determining a first parameter corresponding to an output power with a highest occurrence probability in a target output power range of a power amplifier in a terminal, where the first parameter is used to optimize and control a power added efficiency of the power amplifier, and optimizing the power added efficiency of the power amplifier by using the first parameter.

Abstract: This disclosure relates to the use of certain diaryl macrocycle compounds, specifically (7S13R)-11-fluoro-7,13-di-methyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one in the treatment of disease in mammals. This disclosure also relates to compositions including such compounds, and to methods of using such compositions in the treatment of diseases in mammals, especially in humans.